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Aspirin 325 mg/Butalbital 50 mg/Caffeine 40 mg/Codeine Phosphate 30 mg Rectal Suppository

This formulation is a combination of Aspirin 325 mg, Butalbital 50 mg, Caffeine 40 mg, and Codeine Phosphate 30 mg in a rectal suppository form. It is a solid dosage form that is inserted into the rectum, where it dissolves or melts to release the medication. This formulation is designed for local or systemic absorption.

The Aspirin component acts as an anti-inflammatory and pain reliever, Butalbital is a barbiturate that helps to decrease anxiety and cause sleepiness and relaxation, Caffeine is a stimulant that helps to increase the effects of the other components, and Codeine Phosphate is an opioid pain medication. This combination is typically used to treat conditions such as tension headaches, migraines, pain, and fever.

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Formula Information

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This formulation is a combination of Aspirin, Butalbital, Caffeine, and Codeine Phosphate, compounded into a rectal suppository. Each suppository contains 325 mg of Aspirin, 50 mg of Butalbital, 40 mg of Caffeine, and 30 mg of Codeine Phosphate. This dosage form is designed to be inserted into the rectum, where it dissolves or melts, allowing the medication to be absorbed locally or systemically.

Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain, fever, and inflammation. Butalbital is a barbiturate that helps to decrease anxiety and cause sleepiness and relaxation. Caffeine is a central nervous system stimulant that helps to increase the effects of aspirin and butalbital. Codeine Phosphate is an opioid analgesic that works in the brain to change how your body feels and responds to pain.

This combination medication is used to treat tension headaches, migraines, and other types of pain. The aspirin in the formulation helps to decrease the pain from the headache. The caffeine helps to increase the effects of aspirin. Butalbital is a sedative that helps to decrease anxiety and cause sleepiness and relaxation. Codeine is a narcotic pain reliever that provides relief from severe pain.

It's important to use this medication exactly as prescribed by your healthcare provider. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. This medication can be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for medical advice.

Side effects can occur with any medication, and this formulation is no exception. Common side effects may include drowsiness, lightheadedness, dizziness, sedation, shortness of breath, nausea, vomiting, abdominal pain, and intoxicated feeling. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.

If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Drug Interactions

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This formulation combines Aspirin, Butalbital, Caffeine, and Codeine Phosphate in a rectal suppository form. Each of these active ingredients can interact with other medications, potentially altering their effects or increasing the risk of adverse reactions. It's crucial for patients and prescribers to be aware of these potential interactions.

Aspirin, a nonsteroidal anti-inflammatory drug (NSAID), can interact with anticoagulants like warfarin, increasing the risk of bleeding. It can also interact with other NSAIDs, corticosteroids, and alcohol, potentially leading to gastrointestinal issues. Aspirin may reduce the effectiveness of certain blood pressure medications and can increase the risk of kidney problems when taken with ACE inhibitors or ARBs.

Butalbital, a barbiturate, can interact with other central nervous system depressants like alcohol, antihistamines, benzodiazepines, opioids, and sedative-hypnotics, potentially leading to increased sedation or respiratory depression. It can also interact with monoamine oxidase inhibitors (MAOIs), potentially leading to a hypertensive crisis.

Caffeine can interact with certain antibiotics, increasing its effects and side effects. It can also interact with lithium, reducing its effectiveness, and with echinacea, increasing the effects of caffeine. Caffeine can also interact with certain heart medications, potentially causing rapid heartbeat.

Codeine Phosphate, an opioid analgesic, can interact with other opioids, benzodiazepines, alcohol, and other central nervous system depressants, potentially leading to increased sedation or respiratory depression. It can also interact with certain antidepressants, potentially leading to serotonin syndrome. Codeine may also interact with certain medications for Parkinson's disease, migraine, and certain infectious diseases, potentially altering their effects.

This formulation is typically used to treat conditions like tension headaches, migraines, and moderate to severe pain where an opioid is appropriate. Aspirin works by reducing inflammation and pain, Butalbital helps to decrease anxiety and cause sleepiness and relaxation, Caffeine helps to increase the effectiveness of other components, and Codeine Phosphate works by changing the way the brain and nervous system respond to pain.

It's important to note that this formulation should be used with caution in patients with a history of substance misuse or addiction due to the presence of Butalbital and Codeine. Also, patients with certain medical conditions like liver disease, kidney disease, respiratory disorders, or certain mental health conditions may need to use this medication with caution or may need dose adjustments.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us at Bayview Pharmacy. We're here to help ensure that your medication is safe and effective for you.

How Does it Work

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The Aspirin 325 mg/Butalbital 50 mg/Caffeine 40 mg/Codeine Phosphate 30 mg Rectal Suppository is a unique formulation that combines four active ingredients to provide pain relief and relaxation. This suppository is inserted into the rectum, where it dissolves or melts, allowing the medication to be absorbed both locally and systemically.

Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain, fever, and inflammation. It is often used to treat conditions such as headache, muscle aches, arthritis, and other types of pain.

Butalbital is a barbiturate that helps to decrease anxiety and cause sleepiness and relaxation. It works by slowing down the nervous system. This can help to reduce tension headaches and other types of pain.

Caffeine is a central nervous system stimulant. It works by stimulating the central nervous system, heart, and muscles. Caffeine can help to increase the effectiveness of other medications and reduce feelings of fatigue and lethargy.

Codeine Phosphate is an opioid analgesic that works by changing the way the brain and nervous system respond to pain. It can help to reduce feelings of pain and discomfort in a variety of conditions.

This combination of medications in a rectal suppository form allows for the medication to be absorbed directly into the bloodstream, bypassing the digestive system. This can result in faster relief of symptoms and less potential for stomach upset or other gastrointestinal side effects. The suppository form can also be beneficial for patients who have difficulty swallowing pills or who are unable to take medication orally for other reasons.

As with any medication, it's important to use this formulation as directed by a healthcare provider. Side effects can occur, including drowsiness, dizziness, and constipation. If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy. We are here to help ensure that you understand your medication and can use it safely and effectively.

Other Uses

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This rectal suppository formulation which contains Aspirin 325 mg, Butalbital 50 mg, Caffeine 40 mg, and Codeine Phosphate 30 mg is commonly used to treat conditions related to headaches, muscular and skeletal pain, and migraines. It can be particularly useful in circumstances where oral administration is not feasible, such as nausea or vomiting. However, this formulation could potentially be used for other purposes as well.

Aspirin, a non-steroidal anti-inflammatory drug (NSAID), is known for its analgesic and anti-inflammatory effects. Therefore, it could potentially offer symptomatic relief for other types of pain and inflammation-related conditions. For instance, Aspirin can be utilized in pain management after dental, surgical or other minor procedures. Meanwhile, Butalbital is a barbiturate used for its sedative effects, which makes it potentially useful in treating anxiety and sleep disorders.

Caffeine increases the effectiveness of many analgesics and is used worldwide in conjunction with drugs like aspirin and paracetamol to boost their effect. So, in theory, this formulation could be employed to enhance the performance of other medicinal compounds in pain and fever management, making it potentially useful for a wider array of indications.

Codeine is an opioid analgesic that is often employed in treating severe pain symptoms. Beyond its pain-relieving properties, Codeine is often used as an adjunctive therapy for cough suppression due to its effects on the cough center in the medulla.

However, these potential applications are based on the individual components of the formulation, and the combination does not necessarily imply an additive or synergistic effect on these conditions. Further, it is important to remember, these uses outside of their approved indications should only be considered under the direct supervision and recommendation of a healthcare provider. Pharmacists and healthcare providers should use their professional judgment to determine the appropriateness of off-label use, as this formulation could come with serious side effects, including dependency.

Please note that this summary provides general information about potential other uses for this combination. Always consult your healthcare provider or pharmacist to discuss other potential uses on a patient-specific basis. If you have any questions about this information or about the use of this medication in specific clinical situations, don't hesitate to reach out to us at Bayview Pharmacy.

Frequently Asked Questions

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What is the purpose of Aspirin 325 mg/Butalbital 50 mg/Caffeine 40 mg/Codeine Phosphate 30 mg Rectal Suppository?

This compounded formulation is typically intended for the treatment of pain associated with different health conditions such as migraines, headaches, or other types of severe pain. The different components each have a role to play in controlling pain: Aspirin reduces inflammation and swelling, Butalbital produces sedative effects, Caffeine can increase the efficacy of the other components and Codeine is a strong opioid painkiller.

How is the rectal suppository used?

The suppository is designed to be inserted into the rectum where it will dissolve or melt, allowing the medication to be absorbed by your body either locally or systemically.

What is the advantage of administering the medication as a rectal suppository?

Rectal administration can be a preferred option for those who have difficulty swallowing pills or for those who can't take medication orally due to nausea or vomiting. It may also provide a faster relief than orally consumed medication, as it bypasses the digestive system and delivers medication directly to the systemic circulation.

What is the formulation of this rectal suppository?

The suppository contains 325 mg of Aspirin, 50 mg of Butalbital, 40 mg of Caffeine, and 30 mg of Codeine Phosphate.

Who should use this medication?

It is crucial to only use this medication under the direction and prescription of a healthcare provider. It is typically prescribed for patients who are dealing with severe pain, particularly headaches or migraines.

Are there any side effects to this medication?

Yes, this drug combination can result in side effects such as dizziness, drowsiness, upset stomach or abdominal pain. Serious side effects include mental changes, fainting, seizures, and difficulty urinating. Please consult with your healthcare provider for a complete list of potential side effects.

What precautions should be taken when using this medication?

Do not use this medication if you are allergic to any of its components. It should be used with caution in patients with liver or kidney diseases, as well as in patients with a history of substance abuse, due to the presence of Codeine in the formulation. Always use the dose prescribed by your healthcare professional.

Can this medication be used by pregnant or breastfeeding women?

Do not use this medication without consulting your doctor if you are pregnant or breastfeeding. This medication has the potential to harm an unborn baby and it can pass into breast milk, causing potential harm to your infant.

Can this medication be used in children?

This medication is not recommended for use in children due to the risk of serious side effects associated with Codeine.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. If it is near the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to compensate for a missed one.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.