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Aprepitant 20 mg/mL Oral Suspension

Aprepitant 20 mg/mL Oral Suspension is a liquid dosage form where aprepitant is uniformly dispersed in a liquid medium, ensuring a homogeneous mixture for administration.

This formulation is used to treat nausea and vomiting associated with chemotherapy and postoperative recovery, providing effective management of these conditions.

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Aprepitant
Suspension
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Formula Information

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Aprepitant is a medication used to prevent nausea and vomiting associated with chemotherapy and postoperative recovery. It belongs to a class of drugs known as neurokinin-1 (NK1) receptor antagonists, which work by blocking the action of substance P, a neurotransmitter involved in inducing nausea and vomiting. By inhibiting this pathway, Aprepitant effectively reduces the incidence of these symptoms, improving patient comfort and compliance with treatment regimens.

This formulation is a compounded Aprepitant 20 mg/mL oral suspension. As a liquid dosage form, one or more ingredients are uniformly dispersed throughout a liquid medium, creating a homogeneous mixture for administration. This is particularly beneficial for patients who have difficulty swallowing tablets or capsules, such as pediatric patients or those with swallowing disorders. The liquid form allows for precise dosing adjustments tailored to individual patient needs.

For patients, taking Aprepitant in an oral suspension form can enhance the ease and accuracy of dosing. It is important to measure each dose carefully using a proper measuring device to ensure correct administration. Patients should take the medication exactly as prescribed by their healthcare provider, typically before the start of chemotherapy or surgery, and may continue it for a few days as directed to prevent delayed nausea and vomiting. Common side effects may include fatigue, hiccups, constipation, or loss of appetite. Patients should report any unusual or severe side effects to their healthcare provider promptly.

For prescribers, this compounded oral suspension of Aprepitant offers a customizable option to meet specific patient requirements, especially when standard dosage forms are unsuitable. Compounding allows for precise dosing, which can be essential for achieving optimal therapeutic outcomes in patients with unique needs. Prescribers should provide clear instructions on dosing schedules and emphasize the importance of adherence to prevent breakthrough symptoms of nausea and vomiting. Monitoring for drug interactions is also crucial, as Aprepitant can affect the metabolism of other medications metabolized by CYP3A4 enzymes.

The compounded Aprepitant oral suspension should be stored as recommended, usually in a cool, dry place, and kept out of reach of children. Before each use, the suspension should be shaken well to ensure the medication is evenly distributed. This formulation enhances the flexibility of treatment plans and supports better management of nausea and vomiting in various clinical settings.

If you have any questions about this Aprepitant 20 mg/mL Oral Suspension formulation, please reach out to us. Our team at Bayview Pharmacy is committed to providing personalized care and is here to assist both patients and healthcare providers with any inquiries or needs related to this medication.

Drug Interactions

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Aprepitant 20 mg/mL Oral Suspension is a liquid dosage form designed to provide a homogeneous mixture for administration, ensuring consistent dosing and ease of use, particularly for patients who may have difficulty swallowing tablets or capsules. Aprepitant is primarily used as an antiemetic to prevent nausea and vomiting associated with chemotherapy, postoperative recovery, and other medical conditions. It works by blocking neurokinin-1 (NK1) receptors in the brain, which are involved in the vomiting reflex.

When considering the use of Aprepitant 20 mg/mL Oral Suspension, it is crucial to be aware of potential drug interactions that may affect its efficacy or increase the risk of adverse effects. Aprepitant is known to interact with several medications due to its influence on the cytochrome P450 enzyme system, particularly CYP3A4. This interaction can lead to altered plasma concentrations of aprepitant or the co-administered drugs, necessitating careful monitoring and possible dosage adjustments.

One significant interaction is with corticosteroids such as dexamethasone and methylprednisolone. Aprepitant can increase the plasma concentration of these drugs, potentially enhancing their effects and side effects. It is often recommended to reduce the dose of corticosteroids when used concomitantly with aprepitant. Additionally, aprepitant may decrease the effectiveness of hormonal contraceptives, including birth control pills, patches, and rings. Patients using hormonal contraceptives should be advised to use alternative or additional non-hormonal methods of contraception during treatment and for one month following the last dose of aprepitant.

Aprepitant may also interact with certain chemotherapeutic agents, such as ifosfamide, vinorelbine, and irinotecan, potentially altering their metabolism and increasing the risk of toxicity. Close monitoring and possible dose adjustments of these chemotherapeutic agents may be necessary. Furthermore, aprepitant can affect the metabolism of warfarin, a commonly used anticoagulant, leading to changes in INR levels. Patients on warfarin should have their INR monitored closely, especially after starting or stopping aprepitant therapy.

Other notable interactions include those with benzodiazepines, such as midazolam and alprazolam, where aprepitant may increase their sedative effects. Additionally, aprepitant can interact with certain antifungal agents like ketoconazole and itraconazole, as well as antibiotics such as clarithromycin, which can increase aprepitant levels and the risk of adverse effects. Conversely, the use of strong CYP3A4 inducers like rifampin and carbamazepine can decrease aprepitant plasma concentrations, potentially reducing its antiemetic efficacy.

Given the potential for significant drug interactions, it is essential for both patients and prescribers to review all medications, including over-the-counter drugs and supplements, before starting aprepitant therapy. Patients should be encouraged to report any new medications or changes in their medication regimen to their healthcare provider. If you have any questions or require further information regarding the use of Aprepitant 20 mg/mL Oral Suspension and its potential interactions, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

How Does it Work

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Aprepitant 20 mg/mL Oral Suspension is a compounded liquid formulation designed to provide an effective and convenient method for administering aprepitant, particularly for patients who may have difficulty swallowing tablets or capsules. This formulation is particularly beneficial for pediatric patients, elderly patients, or those with conditions that impair swallowing. The suspension ensures that the active ingredient, aprepitant, is evenly distributed throughout the liquid medium, allowing for precise dosing and consistent therapeutic effects.

Aprepitant is a selective neurokinin-1 (NK1) receptor antagonist that works by inhibiting the action of substance P, a neuropeptide associated with the emetic reflex. By blocking the NK1 receptors in the central nervous system, aprepitant effectively prevents nausea and vomiting, which are common side effects of chemotherapy and postoperative recovery. This mechanism of action makes aprepitant particularly useful in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV), providing relief and improving the quality of life for patients undergoing these treatments.

The oral suspension form of aprepitant offers several advantages over traditional solid dosage forms. It allows for flexible dosing adjustments, which can be particularly important in pediatric or geriatric populations where weight-based dosing is required. The liquid form also facilitates rapid absorption and onset of action, which is crucial in managing acute episodes of nausea and vomiting. Additionally, the suspension can be flavored to improve palatability, enhancing patient compliance and adherence to the prescribed regimen.

For prescribers, the compounded aprepitant oral suspension provides an opportunity to tailor the treatment to the specific needs of the patient, ensuring optimal therapeutic outcomes. It is important to consider the patient's overall treatment plan, potential drug interactions, and any contraindications when prescribing this formulation. As with any medication, monitoring for side effects and adjusting the dose as necessary is essential to ensure safety and efficacy.

Patients and caregivers should be instructed on the proper administration of the oral suspension, including shaking the bottle well before each use to ensure uniform distribution of the active ingredient. Accurate measurement of the dose using an appropriate dosing device is crucial to avoid underdosing or overdosing. Patients should also be informed about the potential side effects of aprepitant, such as fatigue, dizziness, or hiccups, and advised to contact their healthcare provider if they experience any adverse reactions.

If you have any questions or need further information about Aprepitant 20 mg/mL Oral Suspension, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or concerns you may have regarding this formulation.

Other Uses

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Aprepitant 20 mg/mL Oral Suspension is primarily utilized for the prevention of nausea and vomiting associated with chemotherapy and postoperative recovery. However, this formulation may have other potential uses that are being explored in clinical settings. One such area of interest is the management of nausea and vomiting in patients with chronic conditions that are not related to chemotherapy, such as gastroparesis or cyclic vomiting syndrome. These conditions can significantly impact a patient's quality of life, and aprepitant's mechanism of action as a neurokinin-1 (NK1) receptor antagonist may offer symptomatic relief by blocking the action of substance P, a neuropeptide associated with emesis.

Additionally, there is ongoing research into the use of aprepitant for the treatment of certain psychiatric disorders, such as anxiety and depression, where substance P is thought to play a role in the pathophysiology. While these uses are not yet standard practice, they represent promising areas of investigation. The liquid suspension form of aprepitant provides a flexible dosing option, particularly beneficial for pediatric patients or those with swallowing difficulties, ensuring precise dosing and ease of administration.

For prescribers considering off-label use of aprepitant oral suspension, it is crucial to weigh the potential benefits against any risks, as well as to monitor patients closely for any adverse effects. Patients should be informed about the intended use of the medication, potential side effects, and the importance of adhering to the prescribed dosing regimen. As with any medication, it is essential to consult with a healthcare professional before starting treatment with aprepitant for any off-label use. If you have any questions or require further information, please reach out to us at Bayview Pharmacy.

Frequently Asked Questions

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What is Aprepitant 20 mg/mL Oral Suspension used for?

Aprepitant 20 mg/mL Oral Suspension is used to prevent nausea and vomiting caused by chemotherapy or surgery. It works by blocking the actions of chemicals in the body that trigger nausea and vomiting.

How should I store Aprepitant 20 mg/mL Oral Suspension?

Store Aprepitant 20 mg/mL Oral Suspension at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets.

How do I take Aprepitant 20 mg/mL Oral Suspension?

Take Aprepitant 20 mg/mL Oral Suspension exactly as prescribed by your healthcare provider. Shake the bottle well before each use to ensure the ingredients are evenly distributed. Use a proper measuring device to ensure accurate dosing.

Can I take Aprepitant 20 mg/mL Oral Suspension with food?

Yes, Aprepitant 20 mg/mL Oral Suspension can be taken with or without food. Follow your healthcare provider's instructions regarding food intake.

What should I do if I miss a dose of Aprepitant 20 mg/mL Oral Suspension?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time.

Are there any side effects associated with Aprepitant 20 mg/mL Oral Suspension?

Common side effects may include fatigue, diarrhea, hiccups, and dizziness. If you experience any severe side effects or signs of an allergic reaction, contact your healthcare provider immediately.

Can Aprepitant 20 mg/mL Oral Suspension interact with other medications?

Yes, Aprepitant can interact with other medications. Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal supplements, to avoid potential interactions.

Is Aprepitant 20 mg/mL Oral Suspension safe for children?

The safety and effectiveness of Aprepitant in children have not been established. Consult your healthcare provider for guidance if this medication is being considered for a child.

What should I do if I experience an allergic reaction to Aprepitant 20 mg/mL Oral Suspension?

If you experience symptoms of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention.

Can pregnant or breastfeeding women take Aprepitant 20 mg/mL Oral Suspension?

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before taking Aprepitant. They will weigh the potential benefits and risks to determine if it is appropriate for you.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.