Apomorphine Hydrochloride 15 mg Rectal Suppository is a compounded medication formulated to provide an alternative route of administration for apomorphine. Apomorphine is a non-ergoline dopamine agonist that stimulates dopamine receptors in the brain, which is particularly beneficial in managing symptoms of Parkinson's disease. It is primarily used to treat "off" episodes—periods of decreased mobility and increased symptoms in patients with advanced Parkinson's disease.

The rectal suppository form offers a viable option for patients who may have difficulty with oral medications or subcutaneous injections. By inserting the suppository into the rectum, the medication dissolves and is absorbed through the rectal mucosa, entering the bloodstream to exert its therapeutic effects. This route can be advantageous for patients experiencing gastrointestinal issues that impede oral absorption or for those who cannot tolerate injections.

For prescribers, this compounded formulation allows for individualized dosing to meet specific patient needs. It is essential to monitor patients closely when initiating therapy with apomorphine rectal suppositories, adjusting the dose as necessary based on the clinical response and tolerability. Careful consideration should be given to the patient's overall medical condition, concomitant medications, and potential for

Apomorphine HCl 15 mg rectal suppository is a formulation designed for insertion into the rectum, where it dissolves or melts to release the medication for systemic absorption. This formulation is primarily used in the management of Parkinson's disease, particularly for the treatment of "off" episodes, which are periods when other medications are not working well, leading to increased symptoms such as tremors, stiffness, and difficulty moving.

When considering the use of Apomorphine HCl rectal suppositories, it is crucial to be aware of potential drug interactions that may affect the efficacy and safety of the treatment. Apomorphine is a dopamine agonist, and its interactions with other medications can influence its pharmacokinetics and pharmacodynamics.

Concomitant use of apomorphine with other central nervous system depressants, such as benzodiazepines, opioids, or alcohol, can enhance sedative effects, leading to increased drowsiness or dizziness. Patients should be advised to avoid or limit the use of such substances while using apomorphine suppositories.

Apomorphine may also interact with medications that affect blood pressure. It can cause orthostatic hypotension, and when used with antihypertensive drugs, there is a risk of additive hypotensive effects. Patients should be monitored for signs of low blood pressure, such as dizziness or fainting, especially when standing up from a sitting or lying position.

Additionally, apomorphine is contraindicated with 5HT3 antagonists, such as ondansetron, due to the risk of profound hypotension and loss of consciousness. Patients and prescribers should ensure that these medications are not used concurrently.

There is also a potential interaction with dopamine antagonists, such as antipsychotics, which may reduce the effectiveness of apomorphine by blocking dopamine receptors. This can lead to a worsening of Parkinson's symptoms, and alternative treatments should be considered if possible.

Patients using apomorphine should be aware of the potential for interactions with other medications they may be taking, including over-the-counter drugs and supplements. It is important to inform healthcare providers of all medications being used to assess for possible interactions.

If you have any questions or concerns about the use of Apomorphine HCl 15 mg rectal suppositories and potential drug interactions, please reach out to us for further information and guidance.

Apomorphine HCl 15 mg Rectal Suppository is a specialized formulation designed to deliver the active pharmaceutical ingredient, apomorphine hydrochloride, directly into the rectal cavity. This solid dosage form is crafted to dissolve or melt upon insertion, allowing the medication to be absorbed through the rectal mucosa. The rectal route of administration is particularly advantageous for patients who may have difficulty swallowing oral medications or for those who require rapid onset of action due to its ability to bypass the gastrointestinal tract and first-pass metabolism in the liver.

Apomorphine is a non-selective dopamine agonist that primarily stimulates dopamine receptors in the brain. It is commonly used in the management of Parkinson's disease, a neurodegenerative disorder characterized by the depletion of dopamine in the brain, leading to symptoms such as tremors, rigidity, and bradykinesia. By activating dopamine receptors, apomorphine helps to restore the balance of neurotransmitters, thereby alleviating these motor symptoms and improving the quality of life for patients with Parkinson's disease.

The rectal suppository form of apomorphine HCl offers several benefits. It provides an alternative route of administration for patients who experience nausea or vomiting, which can be a side effect of oral medications or a symptom of the disease itself. Additionally, the rectal route can offer a more consistent absorption profile, potentially leading to more stable plasma concentrations and improved symptom control. This can be particularly beneficial during off periods or when oral administration is not feasible.

For prescribers, it is important to consider the individual needs of the patient when selecting this formulation. Factors such as the severity of symptoms, the patient's ability to tolerate other forms of medication, and the need for rapid symptom relief should be taken into account. The 15 mg dosage is carefully calibrated to provide effective symptom management while minimizing potential side effects, although individual responses may vary.

Patients using apomorphine HCl rectal suppositories should be instructed on the proper method of administration to ensure optimal absorption and efficacy. It is recommended to insert the suppository after a bowel movement to enhance absorption and reduce the likelihood of expulsion. Patients should also be advised to remain lying down for a few minutes after insertion to facilitate the dissolution and absorption of the medication.

If you have any questions about this formulation or its use in treating Parkinson's disease, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to make informed decisions about your treatment options.

Apomorphine HCl 15 mg rectal suppositories are primarily used for the management of Parkinson's disease, particularly for the treatment of "off" episodes in patients who experience sudden and unpredictable periods of immobility. However, this formulation may have other potential uses that could be beneficial for both patients and prescribers to consider. One such use is in the management of erectile dysfunction (ED), particularly in cases where traditional oral medications are ineffective or contraindicated. Apomorphine acts as a dopamine agonist, which can stimulate the central nervous system pathways involved in sexual arousal and erection. The rectal suppository form may offer an alternative route of administration for patients who have difficulty swallowing pills or who experience gastrointestinal side effects from oral medications.

Additionally, apomorphine has been explored for its potential use in treating certain psychiatric conditions, such as depression and bipolar disorder, due to its dopaminergic activity. While not a first-line treatment, it may be considered in specific cases where other treatments have failed or are not well-tolerated. The rectal suppository form can provide a more consistent absorption rate and bypass first-pass metabolism, potentially leading to more stable plasma levels and improved therapeutic outcomes.

Furthermore, apomorphine may have a role in managing certain types of chronic pain, particularly those with a neuropathic component. Its action on dopamine receptors can modulate pain perception and provide relief in patients who do not respond adequately to conventional analgesics. The rectal route can be advantageous for patients who require rapid onset of action or who have compromised oral intake due to nausea or vomiting.

It is important for both patients and prescribers to weigh the benefits and risks of using apomorphine HCl rectal suppositories for these alternative indications. As with any medication, careful consideration of the patient's overall health status, potential drug interactions, and specific treatment goals is essential. If you have any questions or need further information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or concerns you may have.