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Formulas

Amlodipine Besylate 0.87 mg/ml Transdermal Gel

This formulation of Amlodipine Besylate 0.87 mg/ml Transdermal Gel is a semisolid preparation designed for easy and accurate application on the skin. Dispensed through a pump mechanism, it allows for targeted treatment or absorption of the active ingredient, Amlodipine Besylate, in a gel-like consistency. This medication is primarily used to treat hypertension and angina, providing a convenient and non-invasive alternative to oral administration.

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Topical Gel
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Formula Information

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Amlodipine Besylate 0.87 mg/ml Transdermal Gel is a specially formulated medication designed for easy application and targeted treatment. This semisolid formulation is dispensed through a pump mechanism, which allows for precise dosage and application. The gel-like consistency ensures that the active ingredient, Amlodipine Besylate, is absorbed effectively through the skin.

Amlodipine Besylate is a calcium channel blocker that works by relaxing blood vessels so blood can flow more easily. It is commonly used to treat high blood pressure (hypertension) and prevent chest pain (angina). By lowering high blood pressure, it helps prevent strokes, heart attacks, and kidney problems. In the case of angina, it increases the ability of the heart to receive blood and oxygen, thereby preventing chest pain.

Transdermal application of Amlodipine Besylate offers several advantages over oral administration. It bypasses the digestive system, reducing the risk of gastrointestinal side effects. It also provides a steady release of medication over time, ensuring consistent therapeutic levels in the bloodstream. This can be particularly beneficial for patients who have difficulty swallowing pills or who experience side effects from oral medications.

It's important to note that this medication should be used as directed by a healthcare professional. The dosage is based on the patient's medical condition and response to treatment. It should be applied to clean, dry skin and the application site should be rotated to prevent skin irritation. Patients should also continue to take this medication even if they feel well, as hypertension often has no symptoms.

As with any medication, Amlodipine Besylate Transdermal Gel may cause side effects. Common side effects include dizziness, lightheadedness, swelling ankles/feet, or flushing. If any of these effects persist or worsen, patients should inform their doctor or pharmacist promptly.

If you have any questions about Amlodipine Besylate 0.87 mg/ml Transdermal Gel, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide you with the information you need to make informed decisions about your healthcare.

Drug Interactions

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Amlodipine Besylate is a calcium channel blocker that is commonly used to treat high blood pressure and angina (chest pain). It works by relaxing the blood vessels, allowing blood to flow more easily, thereby reducing the heart's workload and the pain caused by angina. This transdermal gel formulation allows for targeted treatment and absorption of the active ingredient.

It's important to be aware of potential drug interactions when using Amlodipine Besylate. Certain medications can affect how Amlodipine Besylate works, potentially leading to side effects or reduced effectiveness. Here are some key interactions to be aware of:

Simvastatin: When used together with Amlodipine, the concentration of Simvastatin in the body can increase, potentially leading to more side effects such as muscle pain or weakness. Your healthcare provider may need to adjust your Simvastatin dose if you are using these medications together.

Diltiazem: This medication can increase the level of Amlodipine in your body, potentially leading to more side effects. If you are taking these medications together, your healthcare provider may monitor you more closely or adjust your dose as necessary.

Clarithromycin: This antibiotic can increase the concentration of Amlodipine in your body, potentially leading to more side effects. If you are taking these medications together, your healthcare provider may need to adjust your dose.

Other blood pressure medications: Using Amlodipine with other medications that lower blood pressure can increase your risk of low blood pressure (hypotension). Your healthcare provider may need to adjust your dose or monitor your blood pressure more closely.

It's also important to note that grapefruit and grapefruit juice can increase the concentration of Amlodipine in your body, potentially leading to more side effects. It's generally recommended to avoid grapefruit products while using Amlodipine.

This is not a complete list of potential drug interactions. Always inform your healthcare provider of all the medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. If you have any questions about drug interactions or your medication, don't hesitate to reach out to us at Bayview Pharmacy. We're here to help.

How Does it Work

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Amlodipine Besylate 0.87 mg/ml Transdermal Gel is a unique formulation that allows for the delivery of the active ingredient, Amlodipine Besylate, directly through the skin. This is achieved by using a semisolid gel base that is dispensed through a pump mechanism. This allows for easy and precise application on the skin, ensuring that the correct dosage is applied each time.

The active ingredient, Amlodipine Besylate, is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. This relaxation allows for the blood vessels to widen or dilate, which in turn reduces the amount of work the heart has to do to pump blood around the body. This reduction in workload and the subsequent decrease in the heart's oxygen demand helps to prevent or reduce the symptoms of diseases such as angina (chest pain) and hypertension (high blood pressure).

When applied to the skin, the Amlodipine Besylate in the gel is absorbed directly into the bloodstream. This method of delivery bypasses the digestive system, reducing the chance of gastrointestinal side effects and allowing for a more targeted treatment. The gel formulation also allows for a slow and steady release of the medication, providing a consistent level of drug in the bloodstream over time.

It's important to note that while this formulation can provide significant benefits, it's not suitable for everyone. Patients with certain skin conditions or sensitivities may not be able to use this formulation. Additionally, as with any medication, there may be potential side effects, including swelling of the hands, feet, ankles, or lower legs; headache; upset stomach; or dizziness. It's important to discuss these potential risks and benefits with your healthcare provider before starting treatment.

If you have any questions about Amlodipine Besylate 0.87 mg/ml Transdermal Gel, or if you would like more information about how it works, please don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is always here to help.

Other Uses

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Amlodipine Besylate 0.87 mg/ml Transdermal Gel, in addition to its primary use, can have several other therapeutic applications. This medication, a powerful calcium channel blocker, is commonly used to treat high blood pressure and angina (chest pain). Its mechanism of action involves relaxing blood vessels, which helps to lower blood pressure and reduce the workload on the heart. This makes it particularly potent in dealing with cardiovascular issues and conditions.

Apart from these established applications, the transdermal method of delivery for Amlodipine Besylate allows for the potential utilization in other areas of medicine. For example, it could potentially be used off-label for treatment of Raynaud's phenomenon. Raynaud's is a condition that affects blood flow to the extremities and can cause pain and discomfort. Given that the primary action of this formulation is dilating blood vessels, it could potentially improve symptoms for those with this condition.

Another possible use of this formulation could be in the management of certain arrhythmias, particularly supraventricular tachycardia, due to its ability to slow the conduction through the AV node. Furthermore, due to its blood pressure-lowering properties, physicians may also consider it as an option for patients needing to reduce their overall cardiovascular risk, particularly those with histories of stroke or heart attack.

Potential users should be aware that while this formulation may have additional uses beyond its primary indication, it is essential to use it under direct supervision of an experienced healthcare provider who can assess the potential benefits and risks, and monitor the patient's response to the medication. It’s crucial to understand that each person’s medical profile is unique and may present different potential reactions or side effects.

If you have any questions regarding the above information or regarding the use of Amlodipine Besylate 0.87 mg/ml Transdermal Gel for other diseases or conditions, please don't hesitate to reach out to us. Our team at Bayview Pharmacy is available and ready to assist with the needs of both patients and prescribing physicians.

Frequently Asked Questions

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What is the Amlodipine Besylate 0.87 mg/ml Transdermal Gel?

This is a semisolid formulation of Amlodipine Besylate, dispensed through a pump mechanism. It is applied to the skin for targeted treatment or absorption of the active ingredient, in a gel-like consistency.

How does a transdermal gel work?

A transdermal gel enables a drug to be absorbed through the skin and into the bloodstream. This allows the drug to bypass the digestive system, providing a targeted method of delivery that can offer more precise control over the drug levels in the body.

How should I use the Amlodipine Besylate Transdermal Gel?

Apply the gel as directed by your healthcare provider. Use only the quantity prescribed and apply it to the specified areas of the skin. Do not use more than the recommended dose or use it more frequently than instructed.

What precaution should I take when using this gel?

Avoid applying the gel to broken, damaged or irritated skin. Make sure your skin is clean and dry before using the gel. It should neither be ingested nor applied to the eyes or mucous membranes.

Do I need a prescription for Amlodipine Besylate Transdermal Gel?

Yes, Amlodipine Besylate Transdermal Gel is available by prescription only. It should be used under the supervision of a healthcare provider to ensure safe and effective use.

Are there any side effects of Amlodipine Besylate Transdermal Gel?

As with any medication, Amlodipine Besylate can have side effects, although it's not common when applied topically. Potential side effects may include skin irritation or redness at the application site. If you experience any unusual effects, contact your healthcare provider immediately.

How do I store Amlodipine Besylate Transdermal Gel?

Amlodipine Besylate Transdermal Gel should be stored at room temperature, away from heat and direct sunlight. Keep it out of the reach of children and pets.

What if I miss a dose?

If you miss a dose, apply it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra gel to make up for a missed dose.

What should I do in case of an overdose?

Seek immediate medical attention if you suspect an overdose or experience serious side effects. Symptoms may include severe dizziness, fainting or a rapid heartbeat.

Can I use this gel concurrently with other medications?

Before using Amlodipine Besylate Transdermal Gel, inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter medications, vitamins, and herbal products, as some drugs can interact with this medicine and affect its efficacy or risk of side effects.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.