Sublingual Semaglutide (generic Ozempic®) now available! Get Started
Dashboard
Formulas

Amitriptyline HCl 2%/Ibuprofen 10%/Lidocaine HCl 5%/Orphenadrine HCl 5% Topical Gel

This formulation is a combination of Amitriptyline HCl 2%, Ibuprofen 10%, Lidocaine HCl 5%, and Orphenadrine HCl 5% in a topical gel. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The formulation is designed to treat a variety of disease states. Amitriptyline HCl is a tricyclic antidepressant that can help manage chronic pain. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation. Lidocaine HCl is a local anesthetic that provides temporary relief from pain and discomfort. Orphenadrine HCl is a muscle relaxant that helps to relieve pain and stiffness in muscles and can be used in the treatment of muscle spasms.

Want a different strength?
Click the Text Us button below.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
Starting at
Must be E-Prescribed
Get Started
Generate LeafletShow Leaflet
This medication requires a prescription from your doctor
Trusted by 60,357 patients to date.
A group of faces of our past satisfied patients.
A svg symbol of a mortar and pestle with ingredients going in.
Custom made in our compounding labs.
Sliders that show the customization of ingredients.
Personalized treatment for better results.
User with a gear showing the personalization of the formulation.
All strengths and ingredients are tailored to your needs.
This medication is not available at retail pharmacies. It is compounded, and may be more effective at treating you or your patient.
Topical Gel
653018f77a5cc2736c33f1e9
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Dosing Calculator

Get general dosing information for a patient by using this calculator.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Formula Information

A small arrow pointing down

This formulation is a compounded topical gel containing Amitriptyline HCl 2%, Ibuprofen 10%, Lidocaine HCl 5%, and Orphenadrine HCl 5%. It is designed to be dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively into the targeted area for optimal therapeutic effect.

Amitriptyline HCl is a tricyclic antidepressant that is used in this formulation for its analgesic properties. It works by increasing the levels of certain chemicals in the brain that help elevate mood and reduce the sensation of pain. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain in the body by inhibiting the production of prostaglandins, substances in the body that cause inflammation.

Lidocaine HCl is a local anesthetic that works by blocking nerve signals in your body, thereby reducing pain and discomfort in the applied area. Orphenadrine HCl is a muscle relaxant that works by blocking pain sensations between the nerves and the brain. It is used to treat muscle spasms and to relieve pain and stiffness in muscles.

This formulation is particularly useful in managing conditions that involve pain and inflammation, such as arthritis, muscle spasms, neuropathic pain, and fibromyalgia. By applying the gel directly to the affected area, patients can experience targeted relief from pain and inflammation. The combination of these four active ingredients provides a multi-modal approach to pain management, addressing pain at different levels and through different mechanisms.

It is important to use this medication as directed by your healthcare provider. Apply a thin layer of the gel to the affected area and rub in gently until it is absorbed. Do not apply this medication to broken or irritated skin. Avoid contact with eyes, nose, mouth, and other sensitive areas. If you experience any adverse reactions such as rash, itching, severe dizziness, or trouble breathing, contact your healthcare provider immediately.

As compounding pharmacists, we are here to answer any questions you may have about this formulation. Please do not hesitate to reach out to us if you need further information or clarification.

Drug Interactions

A small arrow pointing down

This formulation contains Amitriptyline HCl, Ibuprofen, Lidocaine HCl, and Orphenadrine HCl. Each of these active ingredients can interact with other medications, potentially altering their effects. It's important to inform your healthcare provider about all the medications you're currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements.

Amitriptyline HCl is a tricyclic antidepressant that can interact with MAO inhibitors, SSRIs, anticholinergic drugs, and certain antihypertensive medications. Combining these medications can lead to serious side effects such as serotonin syndrome, increased heart rate, and elevated blood pressure. It's also important to avoid alcohol while using this medication as it can increase drowsiness and dizziness.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can interact with blood thinners, other NSAIDs, corticosteroids, and certain antihypertensive medications. These interactions can increase the risk of gastrointestinal bleeding and impair kidney function. Ibuprofen can also reduce the effectiveness of certain blood pressure medications.

Lidocaine HCl is a local anesthetic that can interact with other local anesthetics and certain heart medications. These interactions can lead to serious side effects such as slow heart rate, low blood pressure, and seizures. It's also important to avoid applying this medication to broken or inflamed skin as it can increase absorption and lead to systemic side effects.

Orphenadrine HCl is a muscle relaxant that can interact with anticholinergic drugs, certain antihistamines, and MAO inhibitors. These interactions can increase the risk of side effects such as dry mouth, constipation, urinary retention, and confusion. It's also important to avoid alcohol while using this medication as it can increase drowsiness and dizziness.

This formulation is designed to provide targeted treatment for conditions such as muscle pain, inflammation, and nerve pain. Amitriptyline HCl can help manage nerve pain, Ibuprofen can reduce inflammation and pain, Lidocaine HCl can numb the affected area, and Orphenadrine HCl can relax the muscles. However, it's important to use this medication as directed by your healthcare provider and report any side effects immediately.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us. We're here to help ensure that your treatment is safe and effective.

How Does it Work

A small arrow pointing down

This unique formulation combines four active ingredients: Amitriptyline HCl, Ibuprofen, Lidocaine HCl, and Orphenadrine HCl, each with its own mechanism of action to provide relief from pain and inflammation.

Amitriptyline HCl is a tricyclic antidepressant that works by increasing the levels of certain chemicals in the brain that help improve mood, sleep, and the body's response to pain. When applied topically, it can help reduce pain signals from the skin to the brain, providing localized relief.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing the production of prostaglandins, substances in the body that cause inflammation. This helps to decrease swelling, pain, or fever. When applied topically, it provides targeted relief from pain and inflammation at the site of application.

Lidocaine HCl is a local anesthetic that works by blocking nerve signals in your body. It is used topically to reduce pain or discomfort caused by skin irritations. It numbs the skin and surrounding area, providing immediate relief from pain.

Orphenadrine HCl is a muscle relaxant that works by blocking certain nerve impulses to provide relief from muscle spasms. It is used topically to provide localized relief from muscle pain and stiffness.

This formulation is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively into the skin for targeted treatment.

This formulation can be used to treat various disease states that involve pain and inflammation, such as arthritis, muscle sprains and strains, nerve pain, and other conditions as directed by a healthcare provider.

It is important to use this medication as directed by your healthcare provider. Avoid contact with eyes, nose, mouth, and other sensitive areas. If you experience any side effects, such as skin irritation or allergic reactions, stop using the product and contact your healthcare provider immediately.

If you have any questions about this formulation, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Other Uses

A small arrow pointing down

While the primary use of the Amitriptyline HCl 2%/Ibuprofen 10%/Lidocaine HCl 5%/Orphenadrine HCl 5% Topical Gel is to treat pain associated with conditions such as arthritis, nerve disorders, and muscle injuries, it also possesses several other utilities.

Firstly, this formulation can be used as an adjuvant in the management of neuropathic pain, such as post-herpetic neuralgia, post-stroke pain, diabetic neuropathy, and spinal cord injury. The combination of Amitriptyline, an antidepressant with analgesic properties, and Lidocaine, a local anesthetic, effectively numbs the area and lessens discomfort.

Secondly, the presence of Orphenadrine, a muscle relaxant, can provide significant benefit for patients suffering from muscle sprains and strains, muscular dystrophies or post-surgical muscle tension. The Ibuprofen in the formulation further amplifies the analgesic and anti-inflammatory effects for such conditions.

Additionally, the gel may be useful in managing conditions marked by muscle spasticity, like Multiple Sclerosis or certain types of cerebral palsy. It has also been used off-label for treating fibromyalgia and certain types of migraines, particularly those associated with muscle tension.

It is of utmost importance for users to consult with their respective healthcare professionals before considering this formulation for other uses. This ensures that potential benefits are evaluated against possible risks, including known side-effects such as skin irritation or allergic reactions.

If you have any further concerns or questions about the usage of the Amitriptyline HCl 2%/Ibuprofen 10%/Lidocaine HCl 5%/Orphenadrine HCl 5% Topical Gel, please do not hesitate to reach out to us at Bayview Pharmacy. As expert compounding pharmacists, we are happy to assist and inform you about your medication to the best of our knowledge.

Frequently Asked Questions

A small arrow pointing down

What is Amitriptyline HCl 2%/Ibuprofen 10%/Lidocaine HCl 5%/Orphenadrine HCl 5% Topical Gel?

This is a compounded formulation made from four active ingredients: Amitriptyline HCl, Ibuprofen, Lidocaine HCl, and Orphenadrine HCl, used topically. The specific percentages denote the concentration of each ingredient within the gel.

How do I apply the Amitriptyline HCl 2%/Ibuprofen 10%/Lidocaine HCl 5%/Orphenadrine HCl 5% Topical Gel?

This formulation comes with a pump mechanism. You should apply the recommended amount onto your skin by easily and precisely dispensing the gel using this pump.

What is the purpose of four active ingredients in the formulation?

The four active ingredients in this product are each used for a specific effect. Combined in this particular formulation, they work together to provide a targeted and more efficient treatment regime.

What is the consistency of this product?

The product is semisolid, with a gel-like consistency which allows for easy application and effective absorption.

Can this gel be used anywhere on the body?

Application should be targeted to the area where treatment is intended. Always consult your healthcare provider for precise instructions on where and how to use this gel.

Do I need a prescription for Amitriptyline HCl 2%/Ibuprofen 10%/Lidocaine HCl 5%/Orphenadrine HCl 5% Topical Gel?

Yes, this is a prescription medication and should be used under the supervision and direction of a healthcare provider.

What should I do if I experience any side effects?

If you experience any side effects or adverse reactions, stop the use immediately and contact your healthcare provider.

Is it safe to use this gel if I am pregnant or breastfeeding?

Consult your healthcare provider before using this medication if you are pregnant, planning to become pregnant, or are breastfeeding. They will determine if it is suitable for your condition.

Can I use this gel in conjunction with other medications?

You should discuss all ongoing medications with your healthcare provider before beginning treatment with this compounded formulation to prevent any potential interactions.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it's close to your next application time, skip the missed dose and continue with your regular schedule. Do not double up doses.

Related Formulas

Related Products
Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.