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Amitriptyline HCl 2%/Gabapentin 5%/Ketoprofen 10%/Lidocaine HCl 2% Topical Gel

This formulation is a combination of Amitriptyline HCl 2%, Gabapentin 5%, Ketoprofen 10%, and Lidocaine HCl 2% in a topical gel. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The formulation is designed to treat a variety of disease states. Amitriptyline HCl is a tricyclic antidepressant used to manage chronic pain. Gabapentin is an anticonvulsant and nerve pain medication, often used to treat seizures and pain caused by shingles. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, swelling, and inflammation. Lidocaine HCl is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes. Together, these ingredients provide comprehensive pain management for conditions such as neuropathic pain, post-herpetic neuralgia, osteoarthritis, and other related conditions.

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Topical Gel
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Formula Information

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This formulation is a compounded topical gel containing Amitriptyline HCl 2%, Gabapentin 5%, Ketoprofen 10%, and Lidocaine HCl 2%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively for targeted treatment.

Amitriptyline HCl is a tricyclic antidepressant that is used in this formulation for its analgesic properties. It can help to relieve chronic pain by increasing the levels of certain chemicals in the brain that help to transmit signals between nerve cells. Gabapentin is an anticonvulsant that is also used to treat nerve pain. It works by stabilizing electrical activity in the brain and affecting the way the nerves send messages to the brain.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces hormones that cause inflammation and pain in the body. It is used in this formulation to provide relief from pain and inflammation. Lidocaine HCl is a local anesthetic that works by blocking nerve signals in your body. It is used in this formulation to provide temporary relief of pain and discomfort from skin irritations and minor cuts or burns.

This formulation is used to treat various disease states that involve pain and inflammation. These may include conditions such as neuropathic pain, fibromyalgia, post-herpetic neuralgia, and arthritis. The combination of these four active ingredients provides a multi-modal approach to pain management, targeting different aspects of the pain pathway for more effective relief.

It is important to use this medication as directed by your healthcare provider. Apply a thin layer of the gel to the affected area and rub in gently until it is absorbed. Do not apply this medication to broken or irritated skin. Avoid contact with eyes, nose, mouth, and other sensitive areas. If you experience any side effects such as skin irritation, redness, or swelling, discontinue use and contact your healthcare provider immediately.

If you have any questions about this formulation or its use, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to assist you.

Drug Interactions

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This compounded formulation contains Amitriptyline HCl, Gabapentin, Ketoprofen, and Lidocaine HCl. Each of these active ingredients has its own potential for drug interactions, which can be amplified when used in combination. It's important to consider these interactions when prescribing or using this medication.

Amitriptyline HCl is a tricyclic antidepressant that can interact with MAO inhibitors, SSRIs, anticholinergic drugs, and certain antihypertensive medications. It can also increase the effects of alcohol and other CNS depressants. Concurrent use with other serotonergic drugs can lead to serotonin syndrome, a potentially life-threatening condition.

Gabapentin, an anticonvulsant and nerve pain medication, can interact with antacids, morphine, and hydrocodone, potentially reducing the effectiveness of Gabapentin. Alcohol can increase the nervous system side effects of Gabapentin such as dizziness, drowsiness, and difficulty concentrating.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), can interact with anticoagulants, antiplatelet drugs, corticosteroids, and other NSAIDs, increasing the risk of gastrointestinal bleeding. It can also interact with ACE inhibitors, angiotensin II receptor blockers, and diuretics, potentially reducing their effectiveness and increasing the risk of kidney damage.

Lidocaine HCl, a local anesthetic, can interact with antiarrhythmic drugs and other local anesthetics, potentially leading to additive systemic toxicity. It can also interact with certain antiviral drugs, potentially increasing the risk of Lidocaine HCl side effects.

This formulation is designed to treat various disease states, including neuropathic pain, musculoskeletal pain, and certain types of chronic pain. Amitriptyline HCl and Gabapentin work by altering the way the body senses pain, Ketoprofen reduces inflammation and pain in the body, and Lidocaine HCl works by blocking nerve signals in your body, providing local anesthesia.

It's important to inform your healthcare provider of all medications you are currently taking, including prescription drugs, over-the-counter medications, and dietary supplements, to avoid potential drug interactions. If you have any questions or concerns about this formulation, please don't hesitate to reach out to us at Bayview Pharmacy. We are here to help.

How Does it Work

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This formulation is a combination of four active ingredients: Amitriptyline HCl, Gabapentin, Ketoprofen, and Lidocaine HCl, each playing a unique role in managing pain and inflammation. The formulation is designed to be applied topically, directly to the skin, where it can target the affected area without the need for systemic absorption, reducing the risk of side effects commonly associated with oral medications.

Amitriptyline HCl is a tricyclic antidepressant that has been found to be effective in managing chronic pain, particularly neuropathic pain. It works by increasing the levels of certain chemicals in the brain that help elevate mood and reduce the sensation of pain. When applied topically, Amitriptyline HCl can provide targeted pain relief without the systemic side effects associated with oral administration.

Gabapentin is an anticonvulsant medication that is also used to treat nerve pain. It works by stabilizing electrical activity in the brain and affecting the way the nerves send messages to the brain. In a topical formulation, Gabapentin can provide direct relief to the area of pain, reducing the need for systemic medication and its associated side effects.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. When applied topically, Ketoprofen can provide targeted relief from inflammation and pain, without the gastrointestinal side effects commonly associated with oral NSAIDs.

Lidocaine HCl is a local anesthetic that works by blocking nerve signals in your body. It is used to reduce pain or discomfort caused by skin irritations. In this formulation, Lidocaine HCl provides immediate, localized relief from pain, making it an essential component of this multi-modal pain management approach.

This formulation is dispensed through a pump mechanism, which allows for easy and precise application. The gel-like consistency ensures that the medication stays where it is applied, providing targeted treatment and reducing the risk of systemic side effects. This makes it an excellent option for patients who require ongoing pain management, but who may be at risk of side effects from systemic medications.

If you have any questions about this formulation, or if you would like more information on how it can be used to manage specific disease states, please don't hesitate to reach out to us. We are here to help.

Other Uses

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Aside from its standard use, this formulation of Amitriptyline HCl 2%/Gabapentin 5%/Ketoprofen 10%/Lidocaine HCl 2% Topical Gel can serve other purposes in different disease states. Its ingredients have synergistic effects characterized by superior pain management and inflammation control.

Notably, this unique gel formulation could be used to manage various types of neuropathic pain, such as postherpetic neuralgia (PHN), diabetic peripheral neuropathy, and central neuropathic pain. The active ingredients, particularly Amitriptyline and Gabapentin, are well-known for their effects on neuropathic pain. Their combined effects could provide significant relief for patients who cannot tolerate oral medications or those who do not respond to other topical treatments.

Furthermore, this gel could also be beneficial for patients dealing with osteoarthritis. Ketoprofen, a non-steroidal anti-inflammatory drug (NSAID), is useful for managing pain and inflammation associated with this condition. As a topical treatment, it minimizes the potential for systemic side effects commonly associated with oral NSAIDs.

In addition to pain management, this formulation also has the potential for temporary relief from pruritus (itching) caused by different conditions such as dermatitis, allergies, insect bites, and burns due to its combination of Lidocaine, an anesthetic/pain reliever, and Amitriptyline, a tricyclic antidepressant known for its antipruritic effect.

This medication should only be used on the skin and applied to the area as directed by your healthcare professional. Avoid contact with the eyes, nose, mouth, and other mucous membranes. Also, it's not recommended for those with known hypersensitivity or allergy to any of its components. Being a topical preparation, localized skin reactions may occur but these are generally mild and transient.

It’s vital to keep in mind that while this topical gel has potential benefits for numerous diseases, every individual’s condition is unique, and what works well for one person may not be as effective for another. Always consult with your healthcare provider or a compounding pharmacist before using this formulation for conditions other than originally prescribed.

If you have further questions, concerns or need additional information about this formulation, feel free to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is always ready to assist and provide comprehensive answers to your inquiries.

Frequently Asked Questions

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What is this compounded formulation used for?

This formulated topical gel is typically used to provide relief from pain. The combination of Amitriptyline HCl, Gabapentin, Ketoprofen, and Lidocaine HCl has powerful anesthetic, anti-inflammatory, and analgesic properties.

How do I apply this compounded formulation?

The gel is dispensed through a pump mechanism for easy and precise application on the skin. Simply pump the desired amount onto your hand and apply directly to the affected area.

Is this medication absorbed into the skin?

Yes, the semisolid formulation is designed for targeted treatment and absorption of the active ingredients directly into the skin.

Can I use this formulation on all parts of my body?

Generally, the gel can be applied to the area where relief is required. However, avoid using the formulation on sensitive areas, wounds, or irritated skin. Always follow the advice of your healthcare provider.

What does the gel feel like when applied?

The gel has a semisolid, gel-like consistency, making it smooth and easy to spread on the skin. It provides a soothing effect upon application.

Can this gel be used to treat all types of pain?

This gel is designed to provide relief from certain types of pain such as nerve pain and inflammatory pain, but it may not be suitable for all types of pain. Always consult your healthcare provider for advice on whether this gel is appropriate for your specific needs.

How often should I apply this gel?

The frequency of application will largely depend on the advice of your healthcare provider, based on your specific symptoms and condition. Always follow your provider's instructions.

Does the gel cause any side effects?

As with any medication, potential side effects can occur. Some common side effects may include skin irritation or sensitivity where the gel is applied. Always report any concerns or discomfort to your healthcare provider immediately.

Can I engage in regular activities after applying this gel?

Yes, you can engage in your regular activities after application. However, ensure the gel fully absorbs into your skin and dries before wearing clothing or engaging in activities to prevent friction or rubbing off the product from your skin.

Can this formulation be used alongside other pain medicines?

It's essential to discuss all your medications with your healthcare provider, including any over-the-counter medicines or supplements you are taking. They can advise on potential interactions and ensure this gel is safe and appropriate for your use within your complete medication regimen.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.