Sublingual Semaglutide (generic Ozempic®) now available! Get Started
Dashboard
Formulas

Amitriptyline HCl 10%/Bupivacaine HCl 2.5%/Cyclobenzaprine HCl 2%/Gabapentin 6%/Ketamine HCl 11.5%/Nifedipine 2.5% Topical Gel

This formulation is a compounded topical gel containing Amitriptyline HCl 10%, Bupivacaine HCl 2.5%, Cyclobenzaprine HCl 2%, Gabapentin 6%, Ketamine HCl 11.5%, and Nifedipine 2.5%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency aids in the targeted treatment or absorption of the active ingredients.

The combination of these active ingredients is designed to treat a variety of disease states. Amitriptyline HCl is a tricyclic antidepressant used to manage chronic pain. Bupivacaine HCl is a local anesthetic that provides relief from severe pain and inflammation. Cyclobenzaprine HCl is a muscle relaxant used to alleviate muscle spasms. Gabapentin is an anticonvulsant that helps in managing neuropathic pain. Ketamine HCl is a potent analgesic used for the management of chronic pain, while Nifedipine is a calcium channel blocker used to treat high blood pressure and angina.

Want a different strength?
Click the Text Us button below.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
Starting at
Must be E-Prescribed
Get Started
Generate LeafletShow Leaflet
This medication requires a prescription from your doctor
Trusted by 60,357 patients to date.
A group of faces of our past satisfied patients.
A svg symbol of a mortar and pestle with ingredients going in.
Custom made in our compounding labs.
Sliders that show the customization of ingredients.
Personalized treatment for better results.
User with a gear showing the personalization of the formulation.
All strengths and ingredients are tailored to your needs.
This medication is not available at retail pharmacies. It is compounded, and may be more effective at treating you or your patient.
Amitriptyline Hydrochloride
Bupivacaine Hydrochloride
Cyclobenzaprine Hydrochloride
Gabapentin
Ketamine Hydrochloride
Nifedipine Hydrochloride
Topical Gel
6530937087c33fbb879bd51b
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Dosing Calculator

Get general dosing information for a patient by using this calculator.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Formula Information

A small arrow pointing down

This formulation is a compounded topical gel containing Amitriptyline HCl 10%, Bupivacaine HCl 2.5%, Cyclobenzaprine HCl 2%, Gabapentin 6%, Ketamine HCl 11.5%, and Nifedipine 2.5%. It is designed to be applied directly to the skin, providing targeted treatment for a variety of disease states. The gel is dispensed through a pump mechanism, which allows for easy and precise application.

Amitriptyline HCl is a tricyclic antidepressant that is used in this formulation for its analgesic properties. It can help to relieve chronic pain, particularly neuropathic pain. Bupivacaine HCl is a local anesthetic that can provide temporary relief from pain by blocking nerve signals in your body. Cyclobenzaprine HCl is a muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain. Gabapentin is used to relieve nerve pain following shingles (a painful rash due to herpes zoster infection) in adults. Ketamine HCl is a powerful anesthetic used in this formulation for its ability to provide rapid pain relief. Nifedipine is a calcium channel blocker that can help to reduce muscle tension and spasms.

This unique combination of active ingredients works synergistically to provide relief from a variety of symptoms. The topical application allows for targeted treatment, reducing systemic side effects often associated with oral medications. This makes it a suitable option for patients who may be unable to tolerate oral medications or for those who prefer a topical treatment method.

It's important to note that this is a compounded medication, meaning it is made specifically for you based on a doctor's prescription. It is not a commercially available product and should only be used under the supervision of a healthcare professional. As with any medication, it's important to use this product as directed by your healthcare provider. If you have any questions about this formulation, please don't hesitate to reach out to us at Bayview Pharmacy. We are a team of knowledgeable compounding pharmacists and we are here to help.

Drug Interactions

A small arrow pointing down

This topical gel formulation contains a combination of Amitriptyline HCl, Bupivacaine HCl, Cyclobenzaprine HCl, Gabapentin, Ketamine HCl, and Nifedipine. Each of these active ingredients has its own potential for drug interactions, which can be amplified when used in combination. It's important for patients and prescribers to be aware of these potential interactions to ensure safe and effective use of this medication.

Amitriptyline HCl is a tricyclic antidepressant that can interact with MAO inhibitors, SSRIs, anticholinergic drugs, and certain antihypertensive medications. It can also increase the effects of alcohol and other CNS depressants. Bupivacaine HCl is a local anesthetic that can interact with other local anesthetics and certain antiarrhythmic drugs, potentially leading to additive systemic toxicity.

Cyclobenzaprine HCl is a muscle relaxant that can interact with MAO inhibitors, CNS depressants, and other serotonergic drugs, potentially leading to serotonin syndrome. Gabapentin can interact with antacids, morphine, and hydrocodone, potentially affecting the absorption or efficacy of these drugs.

Ketamine HCl is a general anesthetic that can interact with CNS depressants, including alcohol, opioids, and benzodiazepines, potentially leading to additive CNS depression. Nifedipine is a calcium channel blocker that can interact with beta-blockers, digoxin, and certain antifungal medications, potentially leading to changes in blood pressure or heart rate.

This formulation is designed for topical application, which can reduce the risk of systemic drug interactions. However, systemic absorption can still occur, especially with prolonged use or application to large areas of skin. Therefore, it's important to use this medication as directed and to inform your healthcare provider of all other medications you are taking, including prescription drugs, over-the-counter medications, and dietary supplements.

This formulation is typically used to treat conditions such as neuropathic pain, muscle spasms, and certain types of hypertension. The combination of active ingredients works to numb the affected area, relax the muscles, and reduce pain signals sent to the brain. However, the effectiveness of this medication can be influenced by individual patient factors, including the severity of the condition, the patient's overall health status, and their response to treatment.

If you have any questions about this medication or its potential drug interactions, please don't hesitate to reach out to us. We are here to provide you with the information and support you need to use this medication safely and effectively.

How Does it Work

A small arrow pointing down

This topical gel formulation combines six active ingredients: Amitriptyline HCl, Bupivacaine HCl, Cyclobenzaprine HCl, Gabapentin, Ketamine HCl, and Nifedipine. Each of these ingredients works in a unique way to provide relief from various disease states.

Amitriptyline HCl is a tricyclic antidepressant that works by increasing the levels of certain chemicals in the brain that help improve mood, relieve pain, and promote sleep. In this formulation, it is used for its analgesic properties to help manage chronic pain conditions.

Bupivacaine HCl is a local anesthetic. It works by blocking nerve impulses in your body, which helps to numb the area and reduce pain and discomfort. It is often used in post-surgical pain management or for conditions like neuralgia.

Cyclobenzaprine HCl is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain, helping to relieve muscle spasms. It is commonly used in conditions like fibromyalgia or other muscle-related disorders.

Gabapentin is an anticonvulsant and nerve pain medication. It works by affecting the chemicals and nerves in the body that are involved in the cause of seizures and some types of pain. It is often used in the management of postherpetic neuralgia and other neuropathic pain conditions.

Ketamine HCl is a general anesthetic. It works by blocking certain receptors in the brain to maintain a state of anesthesia. In this formulation, it is used in a much lower dose to help manage chronic pain, particularly neuropathic pain.

Nifedipine is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. In this formulation, it is used for its ability to increase blood flow, which can help enhance the absorption of other medications in the gel and promote healing in the applied area.

This formulation is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The active ingredients are then absorbed through the skin to provide targeted treatment. This method of delivery can be particularly beneficial for patients who have difficulty swallowing pills or who need targeted relief from pain or muscle spasms.

If you have any questions about this formulation or how it works, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Other Uses

A small arrow pointing down

The above formulation contains several active ingredients, each of which has its own range of applications. It's worth noting that while it may be primarily used for pain management in conditions such as fibromyalgia, neuropathic pain, and migraine, the formulation of different analgesic and nerve-calming agents also has potential for use in diverse settings.

Amitriptyline HCl, for instance, is a tricyclic antidepressant that in lower doses can help manage chronic pain, and may also be useful for off-label uses such as irritable bowel syndrome (IBS) and insomnia. In combination with other ingredients, this gel application could have implications for topical relief of these conditions.

Bupivacaine HCl, a local anesthetic, in addition to offering potential pain relief for neuralgia, could similarly be considered for uses such as postherpetic neuralgia and other localized pain syndromes. Gabapentin is another component with a varied uses profile, extending not just to neuropathic pain but even conditions like restless leg syndrome. Ketamine HCl is being explored for its potential in managing refractory depression and acute pain, though mostly in parenteral and oral form currently. The topical form of ketamine in this formulation could offer an exciting area for future exploration.

The muscle relaxant properties of cyclobenzaprine HCl could extend to off-label applications in muscle strain, muscle spasms, and localized discomfort. Nifedipine is lovely known for its vasodilating properties and thus could potentially be considered in conditions requiring improved blood supply. However, the research evidence for such off-label use is yet to be established.

Overall, this formulation offers a mixed bag of ingredients with overlapping yet distinct roles in managing multiple symptoms in various conditions. While it’s primarily angled at pain management, off-label uses should also be kept in mind but always under the supervision of a qualified healthcare provider. Lastly, potential interactions between the agents themselves and any systemic medications the patient may be taking should be considered.

If you need any more information or have any questions about the potential uses of this formulation, please feel free to reach out to us at Bayview Pharmacy. Our expert team of compounding pharmacists is always ready to help you.

Frequently Asked Questions

A small arrow pointing down

What is the main purpose of this compounded formulation?

The main purpose of this formulation is to provide targeted treatment for certain conditions. It has a combination of different active ingredients, each aiming to provide relief from certain symptoms and conditions ranging from pain and inflammation to relaxation of muscle tissue.

How should I use this topical gel?

This gel is designed for topical use only. Apply a specified amount of gel to the affected area as directed by your healthcare provider. The pump mechanism makes it easy to apply the formulation to your skin precisely.

Is this formulation safe for all skin types?

This formulation is generally safe for all skin types, however it is always advisable to consult with a healthcare professional prior to using. If irritation or any unusual reaction occurs, discontinue use and inform your physician.

Why is it in gel form?

The gel form allows for easy application and direct absorption of the active ingredients into the skin. It also enables a precise delivery of medicine to the targeted area, reducing the chances of systemic side effects.

Can I use this compounded formulation intermittently?

Use of this formulation should follow the directions provided by your healthcare provider. It is generally not recommended to use the medicine intermittently without seeking medical advice, as it can affect its effectiveness.

Does this gel formulation have any side effects?

Like any medicine, this compounded formulation can have side effects although they may not occur for everyone. Possible side effects may include skin irritation, redness or rash. If you experience any unusual symptoms besides these, contact your healthcare provider immediately.

Should I wash my hands after applying the gel?

Yes, it is recommended to wash your hands after applying the gel unless your hands are the area being treated. This helps prevent accidental ingestion or contact with sensitive areas, like the eyes.

Is it normal for the gel to feel warm upon application?

Some individuals might feel a sensation of warmth on applying this gel. This is generally normal and is due to the action of certain active components in the formulation. However, if the warmth is accompanied by intense burning or discomfort, discontinue use and consult your healthcare provider.

Can I use this gel under makeup?

Before using this gel under makeup, please discuss it with your healthcare professional. They can give you the best advice according to the nature of your skin and the prescribed use of the medicine.

Do I need a prescription to use this compounded formulation?

Yes, a prescription from a licensed healthcare professional is required to use this formulation. It has several active ingredients, each aimed at treating certain condition and must be used under a professional's guidance to avoid undesired effects.

Related Formulas

Related Products
Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.