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Amitriptyline HCL 2%/Gabapentin 2%/Ketoprofen 5%/Lidocaine HCL 5%/Tetracaine HCL 2% Transdermal Gel

This formulation is a combination of Amitriptyline HCL 2%, Gabapentin 2%, Ketoprofen 5%, Lidocaine HCL 5%, and Tetracaine HCL 2% in a transdermal gel. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The formulation is designed to treat a variety of disease states. Amitriptyline HCL is a tricyclic antidepressant used to treat symptoms of depression. Gabapentin is an anticonvulsant or antiepileptic drug that is also used to relieve nerve pain. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and joint stiffness caused by arthritis. Lidocaine HCL is a local anesthetic used to relieve pain and discomfort caused by skin irritations. Tetracaine HCL is also a local anesthetic used to numb the skin or surfaces of the eyes.

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Topical Gel
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Formula Information

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This formulation is a compounded transdermal gel containing Amitriptyline HCL 2%, Gabapentin 2%, Ketoprofen 5%, Lidocaine HCL 5%, and Tetracaine HCL 2%. It is a semisolid formulation that is dispensed through a pump mechanism, allowing for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively into the skin for targeted treatment.

Amitriptyline HCL is a tricyclic antidepressant that is used in this formulation for its analgesic properties. It can help to alleviate chronic pain, particularly neuropathic pain. Gabapentin is an anticonvulsant that is also used for its analgesic properties, particularly in treating neuropathic pain. It works by calming down nerve activity, thereby reducing pain sensation.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces hormones that cause inflammation and pain in the body. It is used in this formulation to provide relief from pain and inflammation. Lidocaine HCL and Tetracaine HCL are local anesthetics that work by blocking nerve signals in your body, providing a numbing effect on the application area. This can help to provide immediate relief from pain and discomfort.

This formulation is particularly useful in treating various disease states that involve pain and inflammation. These include conditions like neuropathic pain, fibromyalgia, post-herpetic neuralgia, and certain types of arthritis. By delivering the medication transdermally, it allows for targeted treatment, reducing systemic side effects and providing faster relief.

It is important for patients and prescribers to understand that this is a compounded medication, meaning it is made specifically for the patient, based on a doctor's prescription. It is not a commercially available product and should be used under the guidance of a healthcare professional. As with any medication, it is important to use this formulation as directed by your healthcare provider, and report any side effects or adverse reactions immediately.

If you have any questions about this formulation, its uses, or how it can benefit you or your patients, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Drug Interactions

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This compounded formulation contains a combination of Amitriptyline HCL, Gabapentin, Ketoprofen, Lidocaine HCL, and Tetracaine HCL. These active ingredients work synergistically to manage pain, particularly neuropathic pain, and inflammation. However, it's important to be aware of potential drug interactions that may occur with this formulation.

Amitriptyline HCL, a tricyclic antidepressant, may interact with other medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs). Combining these medications can increase the risk of serotonin syndrome, a potentially life-threatening condition. Amitriptyline may also interact with anticholinergic drugs, increasing the risk of side effects such as dry mouth, constipation, and confusion.

Gabapentin, an anticonvulsant, may interact with antacids containing aluminum or magnesium, as they can reduce the absorption of gabapentin. It's recommended to take gabapentin at least 2 hours after taking an antacid. Gabapentin may also increase the effects of certain drugs that cause sedation, including opioids, antihistamines, and alcohol.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), may interact with other NSAIDs, increasing the risk of gastrointestinal bleeding. It may also interact with blood thinners, such as warfarin, and certain blood pressure medications, such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs).

Lidocaine HCL and Tetracaine HCL are local anesthetics. They may interact with other local anesthetics and certain heart medications, such as beta-blockers and calcium channel blockers. These interactions can affect heart rhythm and function.

It's important to inform your healthcare provider of all medications you are currently taking, including prescription drugs, over-the-counter medications, and dietary supplements. This will help your healthcare provider to manage potential drug interactions effectively.

This formulation is intended for topical use only and should not be ingested or applied to broken skin or mucous membranes. If you experience any adverse reactions, such as skin irritation or allergic reactions, discontinue use and contact your healthcare provider immediately.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

How Does it Work

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This formulation is a combination of five active ingredients: Amitriptyline HCL, Gabapentin, Ketoprofen, Lidocaine HCL, and Tetracaine HCL. Each of these ingredients plays a unique role in managing pain and inflammation.

Amitriptyline HCL is a tricyclic antidepressant that is used in this formulation for its analgesic properties. It works by increasing the levels of certain chemicals in the brain that help elevate mood and reduce the sensation of pain.

Gabapentin is an anticonvulsant that is used in this formulation for its ability to treat nerve pain. It works by stabilizing electrical activity in the brain which helps to reduce the sensation of pain in the area where the gel is applied.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces hormones that cause inflammation and pain in the body. It is used in this formulation for its ability to reduce inflammation and relieve pain.

Lidocaine HCL and Tetracaine HCL are local anesthetics that work by blocking nerve signals in your body. They are used in this formulation for their ability to numb the skin and block pain signals on a local level.

The transdermal gel formulation allows for the active ingredients to be absorbed through the skin directly into the affected area. This provides targeted relief from pain and inflammation. The gel is dispensed through a pump mechanism, which allows for easy and precise application.

This formulation can be used to treat a variety of disease states that involve pain and inflammation. These may include conditions like neuropathic pain, arthritis, fibromyalgia, and other conditions where pain management is necessary.

It's important to note that while this formulation can provide significant relief from pain and inflammation, it should be used as part of a comprehensive treatment plan under the guidance of a healthcare provider. Always use this medication as directed by your healthcare provider, and reach out to us if you have any questions or concerns.

Other Uses

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Aside from its common use in managing the chronic and acute pain associated with a variety of conditions, this innovative gel formulation has a range of other potential applications. The combination of Amitriptyline HCL 2%, Gabapentin 2%, Ketoprofen 5%, Lidocaine HCL 5%, and Tetracaine HCL 2% has been shown promising in managing nerve-related pain conditions such as postherpetic neuralgia and diabetic peripheral neuropathy. Their collective efficacy stems from their unique roles: Amitriptyline HCL is a tricyclic antidepressant utilized for its neuropathic pain relieving properties; Gabapentin is an anti-convulsant that helps decrease abnormal excitement in the brain; Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) for its pain relieving and anti-inflammatory effects; Lidocaine HCL, a local anesthetic, and Tetracaine HCL, another potent local anesthetic, both numb the skin and block nerve signals in your body.

Furthermore, this formulation can potentially be utilized off-label for conditions that present similar symptoms. For instance, in managing the pain and nerve-related symptoms commonly encountered in autoimmune diseases such as lupus and rheumatoid arthritis. It may also be helpful in conditions causing chronic muscle or bone pain. Additionally, the gel may find use in sports medicine for its potential ability to manage acute soft tissue injuries and provide temporary relief from muscle or joint pain. Doctors can prescribe this formulation for its anesthetic effect during minor skin procedures as well.

It is important for both patients and prescribers to note that this medication is intended for topical use and should be applied to the skin only. It should not be used on open wounds or damaged skin, and care must be taken to avoid contact with the eyes, mouth, and other mucous membranes. Experience with this medication in pediatric population is limited. Always seek professional medical advice before starting any new treatment, particularly if pregnant, lactating, or taking other medications.

For any further questions, clarifications or discussions about the potential uses and applications of this compounded product, please don't hesitate to reach out to our team at Bayview Pharmacy. We aim to bridge the gap between patients and medications, making healthcare a more personalized and efficient service.

Frequently Asked Questions

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What is the purpose of this compounded formulation?

This is a transdermal gel intended to deliver certain medicines into the body through the skin. This particular compound includes Amitriptyline HCL, Gabapentin, Ketoprofen, Lidocaine HCL, and Tetracaine HCL. The formulation is typically used for pain relief, particularly in cases where oral administration is not preferred, or if the patient has troubles with oral administration.

How should I use this medication?

The medication is dispensed through a pump mechanism for easy application. Apply a thin layer to the affected area(s) as directed by your doctor. It's advised to wash your hands thoroughly before and after application. However, if the medication is meant for your hands, don't wash them after application. Also, avoid contact with your mouth, eyes, and other sensitive areas.

What are the advantages of a "semisolid formulation"?

A semisolid formulation contains the advantage of being easy to apply and having the capacity for precise application. The gel-like consistency allows for a targeted application and facilitates the absorption of the active components into the skin. This makes it very effective for localized delivery of medicines.

What does the percentage indicate in each active ingredient?

The percentages indicate the concentration of each component in the formulation. For example, Amitriptyline HCL is present at a concentration of 2%, meaning there is 2g of Amitriptyline HCL in every 100g of the formulation.

What is the role of each medication in this formulation?

Amitriptyline and Gabapentin are generally used to help with nerve pain. Ketoprofen is a nonsteroidal anti-inflammatory drug that helps reduce pain, swelling, and inflammation. Lidocaine and Tetracaine are local anesthetics, numbing the area to which the gel is applied.

Are there side effects to using this compound medication?

As with any medication, side effects may include skin reactions like redness, itching, or rash. To understand all possible side effects, it's recommended to consult your health care provider and discuss these concerns before starting this regimen.

Is it safe to use this compounded formulation more than once a day?

The dosage instructions will be determined by your healthcare provider and will depend on the severity of your condition and your overall response to the treatment. Using more than the prescribed dose is not recommended without medical consultation.

How should I store this transdermal gel?

It should be kept in a safe place at room temperature. Keep it away from heat, moisture, and direct sunlight. It should also be kept out of reach from children and pets.

Can I use this gel while pregnant or breastfeeding?

The effect of this specific compound on pregnancy or in nursing mothers is not well established. Always consult with your healthcare provider before starting any new medication during pregnancy or while breastfeeding.

What do I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it's almost time for your next dose, then skip the missed dose and resume your regular dosing schedule. Overdosing should be avoided.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.