This formulation combines Amitriptyline HCL 2%, Diclofenac Sodium 5%, and Ketoprofen 10% in a transdermal gel. Amitriptyline HCL is a tricyclic antidepressant that has been found to be effective in treating certain types of chronic pain, particularly neuropathic pain. Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation by inhibiting the production of prostaglandins, substances in the body that cause inflammation. Ketoprofen is another NSAID that works by reducing hormones that cause inflammation and pain in the body.

The transdermal gel formulation allows for targeted application and absorption of these active ingredients. This can be particularly beneficial for patients with localized pain or inflammation, as it allows for direct treatment of the affected area. The gel is dispensed through a pump mechanism, which facilitates easy and precise application.

By combining these three active ingredients, this formulation can provide comprehensive pain relief and anti-inflammatory effects. It may be particularly effective in treating conditions such as osteoarthritis, rheumatoid arthritis, gout, and other conditions characterized by pain and inflammation. Additionally, the inclusion of Amitriptyline HCL may make this formulation effective in treating neuropathic pain conditions, such as post-herpetic neuralgia and diabetic neuropathy.

As with any medication, it's important for patients and prescribers to be aware of potential side effects and interactions. Common side effects may include skin irritation at the application site, and more serious side effects may include stomach bleeding, kidney problems, or heart attack. Patients should inform their healthcare provider of all medications they are currently taking, as this formulation may interact with other drugs.

If you have any questions about this formulation, please don't hesitate to reach out to us. Our team of compounding pharmacists at Bayview Pharmacy is here to provide you with the information and support you need.

This formulation combines Amitriptyline HCL, Diclofenac Sodium, and Ketoprofen in a transdermal gel. These active ingredients work synergistically to provide pain relief and reduce inflammation. Amitriptyline HCL is a tricyclic antidepressant that can help manage chronic pain. Diclofenac Sodium and Ketoprofen are nonsteroidal anti-inflammatory drugs (NSAIDs) that reduce pain and inflammation by inhibiting the production of prostaglandins, substances in the body that cause inflammation.

While this formulation is designed for targeted treatment, it's important to be aware of potential drug interactions. Amitriptyline HCL can interact with other medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs). Combining these medications can increase the risk of serotonin syndrome, a potentially life-threatening condition.

Diclofenac Sodium and Ketoprofen can interact with other NSAIDs, including over-the-counter medications like ibuprofen and naproxen. Using multiple NSAIDs together can increase the risk of gastrointestinal bleeding. These medications can also interact with blood thinners, such as warfarin, increasing the risk of bleeding. Additionally, NSAIDs can reduce the effectiveness of certain blood pressure medications.

It's also important to note that this formulation can interact with alcohol. Drinking alcohol while using this medication can increase the risk of stomach bleeding. Furthermore, Amitriptyline HCL can cause drowsiness, and this effect can be intensified by alcohol.

Patients should inform their healthcare provider of all medications they are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. This will help the healthcare provider to manage potential drug interactions.

This formulation is intended for external use only. It should not be applied to broken skin or open wounds. Patients should avoid contact with eyes, nose, and mouth. If the medication gets in these areas, rinse with water immediately.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us. We are here to help ensure that you receive safe and effective treatment.

This formulation combines three active ingredients: Amitriptyline HCL, Diclofenac Sodium, and Ketoprofen, each with its unique mechanism of action. The formulation is designed to be applied topically, directly to the skin, where it can be absorbed and exert its therapeutic effects.

Amitriptyline HCL is a tricyclic antidepressant that works by increasing the levels of certain chemicals in the brain that help improve mood, pain, and sleep. While it's often used to treat mental/mood problems, it has also been found to be effective in treating certain types of pain. When applied topically, it can provide localized pain relief without the systemic side effects associated with oral administration.

Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain and inflammation. It is often used to treat mild to moderate pain, or signs and symptoms of osteoarthritis or rheumatoid arthritis. In this formulation, it provides localized anti-inflammatory and analgesic effects.

Ketoprofen is another NSAID that works by blocking the production of prostaglandins, substances in the body that cause inflammation and pain. It is used to relieve pain, swelling, and joint stiffness caused by arthritis, gout, bursitis, and tendonitis. In this formulation, it enhances the overall anti-inflammatory and analgesic effects of the gel.

The gel formulation allows for targeted application and absorption of these active ingredients. The semisolid nature of the gel allows it to stay in contact with the skin for a longer period, facilitating better absorption of the active ingredients. The pump mechanism ensures easy and precise application, reducing the risk of overuse or underuse.

This formulation is particularly useful in treating localized pain conditions, such as osteoarthritis, rheumatoid arthritis, bursitis, and tendonitis, where systemic side effects of oral medications are a concern. It can also be used in the management of neuropathic pain, where Amitriptyline's pain-modulating effects can be beneficial.

As with any medication, it's important to use this formulation as directed by your healthcare provider. If you have any questions about this formulation or how to use it, don't hesitate to reach out to us at Bayview Pharmacy. We're here to help.

This compounding formulation is primarily used to provide relief from certain types of pain. Besides, it has some other potential uses, but not limited to. They are as follows:

1. Management of Neuropathic Pains: The combination of Amitriptyline HCL, Diclofenac Sodium, and Ketoprofen is often used for the treatment of several types of neuropathic pains. It serves as a topical alternative to oral medication, providing localized relief without the side effects associated with systemic medication.

2. Musculoskeletal Disorders: The anti-inflammatory properties of diclofenac sodium and ketoprofen make this formulation potentially useful in treating various musculoskeletal disorders such as arthritis, tendinitis, and back pain. The application on the skin can provide direct relief to the affected area.

3. Postherpetic Neuralgia: Both amitriptyline and diclofenac have been shown to be effective in the symptomatic management of postherpetic neuralgia, a painful condition that affects some people after recovering from shingles.

4. Migraine Prophylaxis: Topical amitriptyline has been shown to substantially decrease the frequency and intensity of migraines in some patients, due to its ability to inhibit the reuptake of serotonin and noradrenaline which are involved in the pathophysiology of migraines.

5. Fibromyalgia: Amitriptyline is regarded as one of the most effective drugs in the treatment of fibromyalgia. Topical use of this formulation has the potential to provide symptomatic relief from localised pain and tenderness without causing systemic side effects.

Please note that all these uses are subject to the discretion of healthcare providers and should only be used in the context of an established care plan. We suggest that patients and prescribers reach out to us at Bayview Pharmacy if they have any further queries about the formulation or its uses, as we're always happy to provide additional insight and information.