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Amitriptyline HCL 2%/Baclofen 2%/Gabapentin 6%/Ketoprofen 15%/Lidocaine HCL 5% Transdermal Gel

This formulation is a combination of Amitriptyline HCL 2%, Baclofen 2%, Gabapentin 6%, Ketoprofen 15%, and Lidocaine HCL 5% in a transdermal gel. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The formulation is designed to treat a variety of disease states. Amitriptyline HCL is used for its antidepressant and analgesic properties, Baclofen is a muscle relaxant and antispasmodic agent, Gabapentin is used for its anticonvulsant and analgesic effects, Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for its analgesic and anti-inflammatory properties, and Lidocaine HCL is a local anesthetic used for its numbing effect on the skin and surrounding tissues.

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Amitriptyline Hydrochloride
Gabapentin
Ketoprofen
Lidocaine Hydrochloride
Baclofen
Topical Gel
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Formula Information

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This formulation is a compounded transdermal gel containing Amitriptyline HCL 2%, Baclofen 2%, Gabapentin 6%, Ketoprofen 15%, and Lidocaine HCL 5%. It is a semisolid formulation that is dispensed through a pump mechanism, allowing for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed directly into the targeted area, providing localized relief.

Amitriptyline HCL is a tricyclic antidepressant that is used in this formulation for its analgesic properties. It can help to relieve chronic pain, particularly neuropathic pain. Baclofen is a muscle relaxer and an antispastic agent. It is used to treat muscle symptoms such as spasm, pain, and stiffness. Gabapentin is an anticonvulsant and nerve pain medication that is effective in treating neuropathic pain. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces hormones that cause inflammation and pain in the body. Lidocaine HCL is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes.

This combination of medications in a transdermal gel form allows for targeted treatment of various disease states. It can be particularly beneficial for patients suffering from conditions such as neuropathic pain, fibromyalgia, and musculoskeletal pain. The transdermal application allows for the medication to be absorbed directly into the affected area, providing localized relief without the systemic side effects that can occur with oral medication.

It is important to note that this is a compounded medication, meaning it is made specifically for the patient based on a doctor's prescription. It is not a commercially available product and should only be used under the supervision of a healthcare provider. As with any medication, it is important to use this product as directed by your healthcare provider and report any side effects or adverse reactions immediately.

If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

Drug Interactions

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This compounded formulation contains several active ingredients: Amitriptyline HCL, Baclofen, Gabapentin, Ketoprofen, and Lidocaine HCL. Each of these medications has its own potential for drug interactions, which can be increased when used in combination. It's important to note that while this is a topical formulation, systemic absorption can still occur, leading to potential interactions with other medications taken orally or by other routes.

Amitriptyline HCL is a tricyclic antidepressant that can interact with MAO inhibitors, SSRIs, anticholinergic drugs, and certain antihypertensive medications. It can also increase the effects of CNS depressants such as alcohol, barbiturates, and narcotics.

Baclofen is a muscle relaxant and antispastic agent. It can increase the effects of other CNS depressants, and may interact with medications such as antihypertensives and diuretics. Concurrent use with monoamine oxidase inhibitors (MAOIs) may result in hypotension.

Gabapentin, an anticonvulsant and nerve pain medication, can increase the effects of CNS depressants. It may also interact with antacids, reducing the absorption of gabapentin. Therefore, it is recommended to take gabapentin at least 2 hours after taking an antacid.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can interact with anticoagulants, antiplatelet drugs, corticosteroids, and other NSAIDs, increasing the risk of gastrointestinal bleeding. It may also interact with ACE inhibitors, angiotensin II receptor blockers (ARBs), beta blockers, and diuretics, potentially reducing their effectiveness.

Lidocaine HCL is a local anesthetic that can interact with other local anesthetics and antiarrhythmic drugs, potentially leading to additive systemic toxicity. It may also interact with certain other medications, such as beta-blockers and cimetidine, which can increase the risk of lidocaine toxicity.

This formulation is often used for the management of neuropathic pain, including conditions such as post-herpetic neuralgia, diabetic neuropathy, and other nerve-related pain conditions. The combination of medications works to reduce inflammation, numb the area, and decrease nerve pain signals. However, due to the potential for drug interactions, it's important for patients to inform their healthcare provider of all medications they are currently taking, including over-the-counter drugs and dietary supplements.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information you need to use this medication safely and effectively.

How Does it Work

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This formulation is a combination of five active ingredients: Amitriptyline HCL, Baclofen, Gabapentin, Ketoprofen, and Lidocaine HCL. Each of these ingredients plays a unique role in managing pain and inflammation, and their combined effect can provide significant relief for a variety of disease states.

Amitriptyline HCL is a tricyclic antidepressant that is often used in pain management. It works by increasing the levels of certain chemicals in the brain that help elevate mood and reduce the sensation of pain. Baclofen is a muscle relaxer and an antispastic agent. It works by restoring the balance of certain natural substances (GABA) in the brain. Gabapentin is an anticonvulsant that is also used to manage pain, particularly nerve pain. It works by affecting the chemicals and nerves in the body that are involved in the cause of seizures and some types of pain.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. Lidocaine HCL is a local anesthetic that works by blocking nerve signals in your body, thereby reducing pain and discomfort. When these five ingredients are combined in a transdermal gel, they can provide targeted relief for pain and inflammation.

The transdermal gel is designed to be applied directly to the skin, where it is absorbed into the body. This allows for targeted treatment, as the medication can be applied directly to the area where relief is needed. The gel-like consistency makes it easy to apply, and the pump mechanism allows for precise dosing.

This formulation can be used to treat a variety of disease states, including neuropathic pain, fibromyalgia, musculoskeletal pain, and certain types of chronic pain. It can also be used to manage pain associated with conditions like multiple sclerosis and shingles. As with any medication, it's important to use this formulation as directed by your healthcare provider.

If you have any questions about this formulation, how it works, or how it can be used to manage your specific condition, please don't hesitate to reach out to us. We're here to help and provide you with the information you need to make informed decisions about your health.

Other Uses

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Our unique formulation of Amitriptyline HCL 2%/Baclofen 2%/Gabapentin 6%/Ketoprofen 15%/Lidocaine HCL 5% Transdermal Gel is primarily used in the management of neuropathic pain conditions, such as neuropathy associated with diabetes, post-herpetic neuralgia, and fibromyalgia. Beyond these indications, there may be other potential uses for this compounded medication.

Due to the Gel's blend of active ingredients, it may provide potential benefits for other chronic pain conditions. The Ketoprofen and Lidocaine components provide an anti-inflammatory and local analgesic effect, which may be useful for managing osteoarthritis and soft tissue injuries. The Amitriptyline and Gabapentin components have been shown to have centralized pain-modulating effects, which could be beneficial in treating persistent low back pain, sciatic pain, or even migraines when applied to the occipital region.

It's also important to note that this formulation may provide local relief for painful conditions without the systemic side effects associated with oral medication. This may be particularly useful for geriatric patients or those with systemic contraindications for oral pain management.

Last but not least, the Baclofen component of the gel could have a muscle-relaxing effect. This could potentially be a valuable option for spasticity management in patients with conditions like Multiple Sclerosis or after a stroke.

Remember that the potential uses mentioned above should always be discussed with your healthcare provider. While our formulation is versatile, it should be used with a clear understanding of your specific medical condition and overall health. What might be beneficial for one patient could not be as effective or could even be risky for another, so individualized care is paramount.

If you have any further questions about potential uses for our Amitriptyline/Baclofen/Gabapentin/Ketoprofen/Lidocaine Transdermal Gel formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists would be pleased to provide more detailed information specific to your needs.

Frequently Asked Questions

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What is the Amitriptyline HCL 2%/Baclofen 2%/Gabapentin 6%/Ketoprofen 15%/Lidocaine HCL 5% Transdermal Gel composed of?

This gel is a compounded formulation of five active ingredients: Amitriptyline HCL 2%, Baclofen 2%, Gabapentin 6%, Ketoprofen 15%, and Lidocaine HCL 5%.

What is the purpose of the pump mechanism?

The pump mechanism is designed to facilitate easy and precise application of the gel to the skin. It ensures the correct dosage is applied each time.

How is the gel applied to the skin?

The gel is dispensed through a pump mechanism directly onto the skin. Simply press the pump to dispense the gel and then gently rub into the skin.

What is the consistency of this transdermal gel?

This transdermal gel has a gel-like consistency. It is a semi-solid formulation that allows for easy and targeted application.

What is the purpose of these active ingredients in the gel?

The active ingredients in the gel are intended to treat various ailments. For example, Amitriptyline is often used for pain relief, Baclofen for muscle relaxation, Gabapentin for nerve pain relief, Ketoprofen as an anti-inflammatory, and Lidocaine as a local anesthetic.

How does the gel work once applied to the skin?

The gel works by delivering its active ingredients directly through the skin where it is applied. The ingredients then work at the targeted area to offer relief or to treat symptoms.

Can anyone use this gel?

No, this gel should be used under the guidance and prescription of a healthcare professional. It must not be used by people allergic to any of the ingredients in this gel.

Can this gel be used across multiple areas of the body?

Yes, but it is important to apply the gel as instructed by your healthcare provider. The formulation is designed to provide targeted relief, therefore it is most effective when applied directly to the affected regions.

What should I do if I experience any side effects?

If you experience any side effects or adverse reactions, immediately stop using the product and contact your healthcare provider.

Can the gel be used in conjunction with other medicines?

Before combining therapies, always consult with your healthcare professional. They can provide guidance based on the specific medicine and your personal health status.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.