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Formulas

Albendazole 400 mg Suppositories

Albendazole 400 mg Suppositories are a solid dosage form designed for insertion into a body cavity, typically the rectum, where they dissolve or melt to release medication for local or systemic absorption.

This formulation is used to treat parasitic infections such as neurocysticercosis, caused by the pork tapeworm, and hydatid disease, caused by dog tapeworms. It is an effective option for patients who require an alternative route of administration.

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Formula Information

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Albendazole 400 mg suppositories are a compounded formulation designed for patients requiring antiparasitic treatment administered via the rectal or vaginal route. This solid dosage form is inserted into a body cavity, where it dissolves or melts to release albendazole for local or systemic absorption.

Albendazole is a broad-spectrum anthelmintic medication effective against various parasitic worm infestations, including neurocysticercosis caused by Taenia solium (pork tapeworm), hydatid disease from Echinococcus granulosus (dog tapeworm), and infections caused by hookworms, roundworms, whipworms, and threadworms. By inhibiting microtubule synthesis in parasites, albendazole effectively disrupts their energy production, leading to their eventual death.

The suppository form provides an alternative route of administration for patients who are unable to take oral medications due to nausea, vomiting, difficulty swallowing, or malabsorption issues. This ensures that the medication is effectively absorbed, providing the necessary therapeutic effects to eliminate parasitic infections.

For prescribers, utilizing albendazole in a suppository form can enhance patient compliance and treatment outcomes, especially in pediatric patients or those with gastrointestinal complications. It is essential to assess the patient's condition thoroughly and consider this formulation when oral administration is not feasible.

Patients prescribed albendazole suppositories should adhere strictly to the dosing regimen provided by their healthcare provider. Possible side effects may include abdominal discomfort, headache, dizziness, or local irritation at the site of insertion. It is important to report any adverse effects or concerns to your healthcare provider promptly.

At Bayview Pharmacy, our team of expert compounding pharmacists is committed to providing personalized medication solutions to meet individual patient needs. If you have any questions about albendazole 400 mg suppositories or require further information, please reach out to us.

Drug Interactions

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Albendazole is an anthelmintic medication commonly used to treat a variety of parasitic worm infestations. When formulated as a 400 mg suppository, it is designed for insertion into a body cavity, such as the rectum or vagina, where it dissolves or melts to release the medication for local or systemic absorption. This formulation can be particularly beneficial for patients who have difficulty swallowing oral medications or for those who require localized treatment in the rectal or vaginal area.

When considering the use of Albendazole 400 mg suppositories, it is important to be aware of potential drug interactions that could affect the efficacy and safety of the treatment. Albendazole is metabolized in the liver, primarily by the cytochrome P450 enzyme CYP3A4. Therefore, drugs that induce or inhibit this enzyme can alter the plasma concentration of Albendazole, potentially leading to reduced efficacy or increased risk of adverse effects.

Co-administration with strong CYP3A4 inducers, such as rifampin, phenytoin, or carbamazepine, may decrease the plasma concentration of Albendazole, potentially reducing its therapeutic effect. Conversely, CYP3A4 inhibitors, such as ketoconazole, itraconazole, or grapefruit juice, may increase Albendazole levels, raising the risk of toxicity. Patients and prescribers should be cautious and may need to adjust the dosage of Albendazole or the interacting medication accordingly.

Albendazole may also interact with other medications that affect liver function or are hepatotoxic. Caution is advised when using Albendazole in conjunction with drugs such as valproic acid or methotrexate, as the combination may increase the risk of liver damage. Regular monitoring of liver function tests is recommended in such cases.

Additionally, Albendazole can affect the efficacy of certain medications. For instance, it may reduce the plasma concentration of theophylline, a medication used to treat respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Patients taking theophylline should have their levels monitored and dosage adjusted as necessary when starting or stopping Albendazole treatment.

Patients should inform their healthcare provider of all medications they are currently taking, including over-the-counter drugs and supplements, to assess for potential interactions. Prescribers should carefully evaluate the patient's medication regimen and consider any necessary adjustments to avoid adverse interactions.

If you have any questions or concerns about the use of Albendazole 400 mg suppositories and potential drug interactions, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you with any inquiries you may have.

How Does it Work

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Albendazole 400 mg suppositories are a specialized formulation designed to deliver the active pharmaceutical ingredient, albendazole, directly into the body through insertion into a body cavity, typically the rectum. This method of administration is particularly beneficial for patients who may have difficulty swallowing oral medications or for those who require localized treatment within the gastrointestinal tract. Upon insertion, the suppository dissolves or melts at body temperature, allowing the albendazole to be absorbed through the mucous membranes lining the rectum. This can facilitate both local and systemic absorption, depending on the specific therapeutic needs.

Albendazole is an antiparasitic medication that works by inhibiting the polymerization of tubulin into microtubules, which are essential components of the cellular structure in parasites. This disruption in microtubule formation impairs the parasite's ability to absorb glucose, leading to a depletion of energy stores and eventual death of the parasite. The use of albendazole suppositories can be particularly effective in treating parasitic infections localized in the lower gastrointestinal tract, as the medication is delivered directly to the site of infection, potentially enhancing its efficacy and reducing systemic side effects.

This formulation is used to treat a variety of parasitic infections, including those caused by nematodes, cestodes, and other helminths. It is particularly useful in cases where oral administration is not feasible or when a more direct approach to the site of infection is desired. The rectal administration of albendazole can also bypass first-pass metabolism in the liver, potentially leading to higher bioavailability of the drug and a more rapid onset of action.

For prescribers, it is important to consider the specific needs of the patient when choosing this formulation. Factors such as the type of parasitic infection, the location of the infection, and the patient's ability to tolerate oral medications should be taken into account. Additionally, the use of suppositories may be advantageous in pediatric or geriatric populations, where swallowing pills can be challenging. Patients should be instructed on the proper insertion technique to ensure optimal absorption and therapeutic effect.

Patients using albendazole suppositories should be aware of potential side effects, which may include local irritation or discomfort at the site of insertion. Systemic side effects are generally less common with this route of administration but can include headache, dizziness, or gastrointestinal disturbances. It is important for patients to follow the prescribed dosing regimen and to report any adverse effects to their healthcare provider.

If you have any questions about albendazole 400 mg suppositories or their use in treating parasitic infections, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to ensure safe and effective treatment.

Other Uses

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Albendazole 400 mg suppositories are primarily used for the treatment of parasitic worm infections, but they may have other potential uses that could be beneficial for both patients and prescribers to consider. While the primary indication for albendazole is the treatment of conditions such as neurocysticercosis and hydatid disease, the suppository form offers unique advantages for patients who may have difficulty swallowing oral medications or for those who require localized treatment in the rectal or vaginal area. This formulation can be particularly useful in cases where oral administration is not feasible due to gastrointestinal disturbances, severe nausea, or vomiting, ensuring that patients still receive the necessary medication.

Beyond its antiparasitic properties, albendazole has been studied for its potential anti-cancer effects. Research has suggested that albendazole may inhibit the growth of certain cancer cells, making it a candidate for adjunctive therapy in oncology. The suppository form could provide a novel route of administration for patients undergoing cancer treatment, particularly for those with tumors located in the lower gastrointestinal tract or reproductive organs. Additionally, albendazole's anti-inflammatory properties may offer therapeutic benefits in conditions characterized by inflammation, although more research is needed to fully understand these effects.

For prescribers, it is important to consider the pharmacokinetics of albendazole when administered as a suppository. The absorption and bioavailability may differ from oral formulations, potentially affecting dosing regimens. It is crucial to monitor patients for efficacy and any adverse effects, adjusting the treatment plan as necessary. Patients should be informed about the proper administration of suppositories, including hygiene practices and insertion techniques, to maximize the effectiveness of the treatment and minimize discomfort.

As with any medication, the use of albendazole suppositories should be guided by a thorough evaluation of the patient's medical history and current health status. Prescribers should weigh the potential benefits against any risks, particularly in populations such as pregnant women, where the safety profile of albendazole is not fully established. If you have any questions or need further information about the use of albendazole 400 mg suppositories, please reach out to us at Bayview Pharmacy. We are here to assist both patients and healthcare providers in making informed decisions about their treatment options.

Frequently Asked Questions

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What is Albendazole 400 mg Suppository used for?

Albendazole 400 mg Suppository is used to treat parasitic worm infections. It is inserted into a body cavity, such as the rectum, where it dissolves or melts to release the medication for local or systemic absorption.

How do I use Albendazole 400 mg Suppositories?

To use Albendazole 400 mg Suppositories, insert the suppository into the rectum or vagina as directed by your healthcare provider. Ensure your hands are clean before and after handling the suppository.

What should I do if I miss a dose of Albendazole 400 mg Suppository?

If you miss a dose of Albendazole 400 mg Suppository, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Are there any side effects associated with Albendazole 400 mg Suppositories?

Some common side effects of Albendazole 400 mg Suppositories may include mild irritation or discomfort at the site of insertion. If you experience severe side effects or allergic reactions, contact your healthcare provider immediately.

Can Albendazole 400 mg Suppositories be used during pregnancy?

Albendazole should be used during pregnancy only if clearly needed and prescribed by a healthcare provider. It is important to discuss the potential risks and benefits with your doctor.

How should Albendazole 400 mg Suppositories be stored?

Store Albendazole 400 mg Suppositories at room temperature, away from moisture and heat. Keep them out of reach of children and pets.

Can I use Albendazole 400 mg Suppositories if I am breastfeeding?

If you are breastfeeding, consult your healthcare provider before using Albendazole 400 mg Suppositories to understand any potential risks to your baby.

What should I do if I experience severe side effects from Albendazole 400 mg Suppositories?

If you experience severe side effects, such as intense pain, swelling, or an allergic reaction, seek medical attention immediately.

Can Albendazole 400 mg Suppositories interact with other medications?

Albendazole may interact with other medications. Inform your healthcare provider about all the medications you are currently taking to avoid potential interactions.

How long does it take for Albendazole 400 mg Suppositories to work?

The time it takes for Albendazole 400 mg Suppositories to work can vary depending on the type and severity of the infection. Follow your healthcare provider's instructions for the duration of treatment.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.