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Acyclovir 5%/Amitriptyline HCl 1%/Ibuprofen 3%/Lidocaine 2.5%/Prilocaine 2.5% Topical Gel

This formulation is a compounded topical gel containing Acyclovir 5%, Amitriptyline HCl 1%, Ibuprofen 3%, Lidocaine 2.5%, and Prilocaine 2.5%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The Acyclovir component is an antiviral medication used to treat viral infections, including herpes simplex. Amitriptyline HCl is a tricyclic antidepressant that can help manage chronic pain. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation. Lidocaine and Prilocaine are local anesthetics that numb the skin and decrease pain sensation.

This unique combination of ingredients allows for the treatment of various disease states, including herpes simplex infections, chronic pain conditions, inflammation, and localized pain. The topical application allows for direct treatment of the affected area, reducing systemic side effects and improving patient compliance.

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Acyclovir
Amitriptyline Hydrochloride
Ibuprofen
Prilocaine Hydrochloride
Lidocaine Hydrochloride
Topical Gel
653035bec66757e92bfe3c45
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Formula Information

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This formulation is a compounded topical gel containing Acyclovir 5%, Amitriptyline HCl 1%, Ibuprofen 3%, Lidocaine 2.5%, and Prilocaine 2.5%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively for targeted treatment.

Acyclovir is an antiviral medication used to treat infections caused by certain types of viruses. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. In this formulation, it helps to reduce the pain and speed up the healing of sores or blisters in people who have these conditions.

Amitriptyline HCl is a tricyclic antidepressant that is used to treat various types of pain. It works by increasing the levels of certain chemicals in the brain that help elevate the mood and reduce the sensation of pain. In this formulation, it can help to alleviate neuropathic pain.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce inflammation and relieve pain. In this formulation, it can help to reduce inflammation and provide relief from pain associated with various conditions.

Lidocaine and Prilocaine are local anesthetics that work by causing temporary numbness/loss of feeling in the skin and surrounding tissues. In this formulation, they help to numb the skin and reduce pain or discomfort caused by minor skin irritations, sore throat, sunburn, teething pain, vaginal or rectal irritation, and other conditions.

This compounded formulation is designed to provide targeted relief from pain and discomfort associated with various conditions. It is applied topically, which means it is applied directly to the area of the skin where relief is needed. This allows for the active ingredients to be absorbed directly into the affected area, providing faster and more effective relief.

If you have any questions about this formulation, please do not hesitate to reach out to us. Our team of knowledgeable compounding pharmacists at Bayview Pharmacy is always here to help.

Drug Interactions

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This topical gel formulation contains a combination of Acyclovir, Amitriptyline HCl, Ibuprofen, Lidocaine, and Prilocaine. Each of these active ingredients has its own potential for drug interactions, which can be amplified when used in combination. It's important to inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements.

Acyclovir is an antiviral medication used to treat viral infections such as herpes. It can interact with drugs like Zidovudine or Tenofovir, potentially leading to kidney problems. Also, combining Acyclovir with other nephrotoxic drugs like Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) may increase the risk of kidney damage.

Amitriptyline HCl is a tricyclic antidepressant used to treat various mental/mood disorders. It can interact with MAO inhibitors, SSRIs, anticholinergic drugs, and certain antihypertensive medications. These interactions can lead to serious side effects such as serotonin syndrome, heart problems, or increased blood pressure.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce inflammation. It can interact with drugs like warfarin, aspirin, corticosteroids, and certain antihypertensive medications, potentially leading to increased risk of gastrointestinal bleeding or reduced antihypertensive effect.

Lidocaine and Prilocaine are local anesthetics used to numb the skin or other body parts before medical procedures. They can interact with drugs like beta-blockers, cimetidine, or other local anesthetics, potentially leading to increased risk of systemic toxicity.

This formulation is designed to provide targeted treatment for conditions such as herpes outbreaks, nerve pain, inflammation, and localized pain. The combination of these medications in a topical gel allows for direct application to the affected area, reducing systemic exposure and potential drug interactions. However, it's still important to monitor for potential side effects and inform your healthcare provider if you experience any unusual symptoms.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us. We're here to help ensure that your treatment is safe and effective.

How Does it Work

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This topical gel formulation combines five active ingredients: Acyclovir, Amitriptyline HCl, Ibuprofen, Lidocaine, and Prilocaine. Each of these ingredients plays a unique role in treating various disease states.

Acyclovir is an antiviral medication that works by slowing the growth and spread of the herpes virus in the body. It is used to treat infections caused by certain types of viruses, such as cold sores and shingles. It does not cure herpes, but it can lessen the symptoms of the infection.

Amitriptyline HCl is a tricyclic antidepressant that is often used in pain management. It works by increasing the levels of certain chemicals in the brain that help elevate mood and reduce the sensation of pain. In this formulation, it can help to alleviate neuropathic pain.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. It provides relief from various types of pain, including minor aches and pains, reduces inflammation and swelling, and can also lower a fever.

Lidocaine and Prilocaine are local anesthetics that work by causing temporary numbness/loss of feeling in the skin and mucous membranes. These ingredients are used to prevent pain on the outer layer of the skin during certain procedures or to relieve minor discomfort and itching.

When combined in a topical gel, these ingredients can provide targeted relief from pain, inflammation, and viral infections. The gel is easily applied to the skin, allowing for direct application to the affected area. The pump mechanism ensures a precise dose is dispensed each time, reducing the risk of over-application or under-dosing.

This formulation is designed to treat a variety of disease states, including viral skin infections, localized pain, inflammation, and neuropathic pain. It is important to note that while this formulation can help manage symptoms, it may not cure the underlying condition. Always consult with a healthcare provider for a comprehensive treatment plan.

If you have any questions about this formulation, how it works, or how it can be used in your specific situation, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Other Uses

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This compounded formulation primarily serves to manage shingles, post-herpetic neuralgia, localised neuropathic pain, and numbing skin before certain treatments. It can treat the pain associated with these conditions, diminish inflammation, and combat viral infections. Acyclovir fights against the herpes simplex viruses, thereby lessening the severity and duration of symptoms. Amitriptyline is a tricyclic antidepressant with analgesic properties known to alleviate chronic neuropathic pain. Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), reduces inflammation and pain. Lidocaine and Prilocaine are local anaesthetics numbing skin and relieving discomfort.

Beyond the aforesaid applications, this topical gel may be used for herpes simplex labialis (cold sores) owing to Acyclovir's antiviral activity. This formulation may also treat other types of neuropathic pain (e.g. diabetic neuropathy, neuropathy from chemotherapy). The antiviral, anti-inflammatory, analgesic, and anaesthetic attributes make this combination gel an apt choice for treating minor burns, wounds, and skin abrasions by reducing inflammation, easing pain, and preventing secondary infections.

Furthermore, this preparation could be valuable for treating non-specific lower back pain due to its analgesic and anti-inflammatory properties. While not the primary purpose, the antidepressant properties of Amitriptyline may additionally help those dealing with chronic pain and concurrently experiencing depressive symptoms. Amitriptyline's unique characteristic of blocking histamine receptors could make this formulation helpful for managing pruritus (itch) and urticaria (hives).

It's important for prescribers to understand that use in some of the conditions mentioned above may be deemed off-label, hence it's imperative to evaluate the benefits and risks carefully. Furthermore, due to variable absorption rates through the skin, this gel may not be suitable for systemic conditions, and caution should be exercised in patient populations that may have increased sensitivity to the individual components, including the elderly and those with impaired renal or liver function.

For more information or if any questions arise, don't hesitate to contact us at Bayview Pharmacy. It's our goal to ensure that prescribers and patients are well-informed about the unique benefits and potential applications of all our compounding formulations.

Frequently Asked Questions

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What is the purpose of Acyclovir 5%/Amitriptyline HCl 1%/Ibuprofen 3%/Lidocaine 2.5%/Prilocaine 2.5% Topical Gel?

This compounded formulation is a topical medication. Acyclovir is an antiviral used to treat infections caused by certain types of viruses. Amitriptyline is a tricyclic antidepressant used to treat certain mental/mood problems or to prevent migraines. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce inflammation and pain. Lidocaine and Prilocaine are local anesthetics used to prevent and relieve pain.

What does the percentage signify on each drug compound?

The percentages represent the amount of each active ingredient per unit of the total formulation. For instance, 5% Acyclovir means that in every 100g of the gel, you have 5g of Acyclovir.

How do I use this topical gel?

The gel is dispensed through a pump mechanism and should be applied to the affected area. Ensure you clean and dry the area thoroughly before application, and always follow the prescribing doctor's instructions.

Can this formulation be used for all skin types?

While the formulation is designed for general use, individual reactions can vary. If you have sensitive skin or known dermatological conditions, please consult your healthcare provider before using this gel.

Is it normal to experience a cooling or warming sensation after application?

Some users might experience a mild cooling or warming sensation. However, if irritation or discomfort persists, discontinue use and contact your healthcare provider immediately.

Can I apply the gel on open wounds or broken skin?

Unless advised by a healthcare provider, avoid applying this gel on open wounds or broken skin as this can cause significant discomfort and potential absorption issues.

What should I do in case of accidental ingestion?

If this product is accidentally ingested, seek immediate medical assistance. Keep the package handy to quickly provide information about the ingested substances.

Does the formulation have a shelf-life?

Yes, like all medications, this gel has a shelf-life. Always check the packaging for the expiration date and do not use the product beyond this date.

How should I store this medication?

This formulation should be stored at room temperature, away from light and moisture. Always ensure to keep it out of the reach of children and pets.

Can I use this gel with other medications or skincare products?

Before combining other treatments with this gel, consult your healthcare provider to ensure compatibility and avoid potentially harmful interactions.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.