Squalene is a naturally occurring organic compound that plays a crucial role in various compounded formulations due to its unique properties. It is a triterpene hydrocarbon that is a precursor to cholesterol and other sterols, making it an essential component in the biosynthesis of these vital substances. Squalene is predominantly found in shark liver oil, though it is also present in smaller quantities in olive oil, wheat germ oil, and rice bran oil.

In pharmaceutical applications, squalene is highly valued for its emollient and antioxidant properties, which make it an excellent ingredient in topical formulations. Its ability to penetrate the skin efficiently allows it to deliver active ingredients effectively, enhancing the therapeutic outcomes of compounded medications. Additionally, squalene's biocompatibility and non-irritating nature make it suitable for sensitive skin, further broadening its applicability in dermatological preparations.

Moreover, squalene's role as an adjuvant in vaccine formulations has been explored, where it enhances the immune response without compromising safety. This versatility underscores its importance in both therapeutic and preventive healthcare settings. For prescribers, understanding the multifaceted benefits of squalene can aid in selecting appropriate compounded formulations that leverage its properties for optimal patient outcomes.