Levofloxacin Hydrochloride is a potent fluoroquinolone antibiotic widely utilized in compounded formulations for its broad-spectrum antibacterial properties. It is effective against a variety of gram-positive and gram-negative bacteria, making it a versatile choice for treating infections. This API works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication, transcription, repair, and recombination, ultimately leading to bacterial cell death.

Levofloxacin Hydrochloride is often prescribed for respiratory tract infections, urinary tract infections, and skin infections, among others. Its pharmacokinetic profile allows for excellent tissue penetration, which enhances its efficacy in treating deep-seated infections. The compound is well-absorbed orally, with a bioavailability of nearly 100%, allowing for flexible dosing regimens that can be tailored to the patient's needs.

In the context of compounding, Levofloxacin Hydrochloride can be formulated into various dosage forms, including oral suspensions, topical solutions, and ophthalmic preparations. This flexibility is particularly beneficial for patients who require customized treatment plans, such as those with specific allergies or intolerances to standard formulations. Additionally, the stability of Levofloxacin Hydrochloride in compounded formulations ensures that it maintains its efficacy throughout the treatment period.

Prescribers should be aware of potential side effects, which may include gastrointestinal disturbances, CNS effects, and hypersensitivity reactions. It is crucial to consider patient-specific factors, such as renal function, when determining the appropriate dosage to minimize the risk of adverse effects. Levofloxacin Hydrochloride's interaction profile should also be reviewed, as it may interact with other medications, including antacids and certain antiarrhythmic agents.