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Hydrochlorothiazide is a thiazide diuretic, or water pill, taken by mouth, which a pharmacy may compound on a prescriber's order.
Hydrochlorothiazide is a thiazide diuretic, also called a water pill. It blocks a sodium and chloride transporter in the kidney, so more salt and water leave the body in the urine. Manufactured products include hydrochlorothiazide tablets, capsules and an oral solution, and many combination tablets pair it with blood pressure medicines such as lisinopril, losartan, valsartan, olmesartan, bisoprolol or triamterene. The Teva tablet label lists management of hypertension, alone or with other blood pressure medicines, and adjunctive therapy of edema linked to congestive heart failure, hepatic cirrhosis, corticosteroid or estrogen therapy and some forms of kidney disease. A prescriber might order hydrochlorothiazide compounded in a strength, form or combination that is not manufactured. Compounded preparations are not FDA-approved and require a prescription.
The Teva hydrochlorothiazide label has no boxed warning. Do not use it if your kidneys are not making urine (anuria) or if you are allergic to it or to other sulfonamide-derived drugs. It can upset fluid and electrolyte levels, such as low sodium or potassium; warning signs include dry mouth, thirst, muscle cramps or a fast heartbeat. Sudden blurred vision or eye pain can signal acute myopia or angle-closure glaucoma and needs prompt care. Hydrochlorothiazide is linked to a higher risk of non-melanoma skin cancer, so protect your skin from the sun and get regular skin checks. It may worsen lupus. Lithium generally should not be taken with it, and NSAIDs can blunt its effect. Thiazides pass into breast milk; LactMed considers lower doses acceptable during breastfeeding and notes that intense diuresis with large doses may reduce milk supply. For side effects, talk to your prescriber or pharmacist.
Hydrochlorothiazide inhibits the Na+/Cl- cotransporter (NCC) in the distal convoluted tubule, increasing sodium and chloride excretion in roughly equal amounts, with some loss of potassium and bicarbonate; the mechanism of its antihypertensive effect is unknown. After oral dosing, diuresis begins within 2 hours, peaks at about 4 hours and lasts about 6 to 12 hours. It is not metabolized; plasma half-life varied from 5.6 to 14.8 hours, and at least 61% of an oral dose is eliminated unchanged in the urine within 24 hours. Labeled indications (Teva hydrochlorothiazide tablets): hypertension, alone or with other antihypertensives; adjunctive therapy of edema in congestive heart failure, hepatic cirrhosis, corticosteroid and estrogen therapy, and renal dysfunction. StatPearls describes use to prevent calcium nephrolithiasis and to manage nephrogenic diabetes insipidus; these are not FDA-approved indications. Dosing is per prescriber. StatPearls lists monitoring of serum sodium, potassium, calcium and magnesium, volume status, blood pressure, gout risk, fasting glucose in patients with diabetes or impaired glucose tolerance, renal and hepatic function in existing disease, and phototoxicity. The label advises stopping thiazides before parathyroid function tests. Hydrochlorothiazide is not a controlled substance.
Compounded at Bayview
Patient guides for the preparations we make most often. Each one is compounded to order and requires a prescription.
We do not have a patient page for this ingredient yet. That does not mean we cannot make it. Bayview compounds this ingredient to a prescriber's order, and our full compounding formulary lists every preparation we make. Viewing the formulary requires a prescriber account.
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Every preparation in our formulary that contains this ingredient. Strength, base and dose form are set by the prescription.
Other salt forms of this molecule, and ingredients commonly compounded alongside it.
This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.
Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.
