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Propranolol Hydrochloride 10 mg/mL Oral Suspension

Propranolol Hydrochloride 10 mg/mL Oral Suspension is a liquid dosage form in which propranolol hydrochloride is dispersed uniformly throughout a liquid medium, ensuring a homogeneous mixture for administration. This formulation is primarily used to manage hypertension, angina pectoris, and certain types of arrhythmias. It is also effective in treating conditions such as migraine prophylaxis and essential tremor. The oral suspension allows for precise dosing and is suitable for patients who may have difficulty swallowing tablets.

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Propranolol Hydrochloride
Suspension
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Formula Information

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Propranolol Hydrochloride 10 mg/mL Oral Suspension is a medication formulated as a liquid dosage form, where propranolol hydrochloride is uniformly dispersed throughout a liquid medium to create a homogeneous mixture for administration. This oral suspension is particularly beneficial for patients who have difficulty swallowing tablets or capsules, such as children or the elderly, and allows for precise dosing adjustments to meet individual patient needs.

Propranolol is a non-selective beta-adrenergic receptor blocker that works by inhibiting the action of catecholamines (epinephrine and norepinephrine) on both beta-1 and beta-2 adrenergic receptors. This action results in decreased heart rate, reduced cardiac output, and lowered blood pressure, making it effective in the management of various cardiovascular conditions. It is commonly prescribed for hypertension (high blood pressure), angina pectoris (chest pain), arrhythmias (irregular heartbeats), and prevention of myocardial infarction (heart attack).

In addition to cardiovascular applications, propranolol is used in the treatment of other conditions such as migraine prophylaxis, essential tremor, and certain types of anxiety, including performance anxiety. Its ability to cross the blood-brain barrier allows it to have central nervous system effects, which can be beneficial in these clinical scenarios. The 10 mg/mL oral suspension provides flexibility in dosing, allowing for gradual titration and optimization of therapeutic effects while minimizing side effects.

Patients prescribed this medication should be aware of potential side effects, which may include dizziness, fatigue, gastrointestinal disturbances, and cold extremities due to decreased circulation. It is important to take propranolol exactly as directed by a healthcare provider and not to discontinue use abruptly, as this may lead to adverse cardiovascular events such as rebound hypertension or exacerbation of angina symptoms.

Healthcare providers should consider the patient's overall medical condition before prescribing propranolol, especially in those with respiratory conditions like asthma or chronic obstructive pulmonary disease (COPD), as beta-blockers can induce bronchoconstriction. Caution is also advised in patients with diabetes mellitus, as propranolol may mask signs of hypoglycemia. Regular monitoring of blood pressure, heart rate, and clinical response is recommended to ensure safe and effective use of this medication.

If you have any questions, reach out to us.

Drug Interactions

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Propranolol Hydrochloride 10 mg/mL Oral Suspension is a liquid dosage form designed to provide a homogeneous mixture for administration, ensuring consistent dosing and ease of use, particularly for patients who may have difficulty swallowing tablets. This formulation is commonly used in the management of various cardiovascular conditions, including hypertension, angina pectoris, and arrhythmias, as well as in the treatment of anxiety and migraine prophylaxis. However, it is crucial to be aware of potential drug interactions that may affect the efficacy and safety of propranolol when used in combination with other medications.

Propranolol is a non-selective beta-adrenergic receptor blocker, and its interaction profile is influenced by its mechanism of action. Concomitant use of propranolol with other antihypertensive agents, such as calcium channel blockers (e.g., verapamil, diltiazem), can lead to additive effects, potentially resulting in excessive hypotension or bradycardia. Patients should be monitored closely for signs of low blood pressure and slow heart rate, and dose adjustments may be necessary.

Co-administration with antiarrhythmic drugs, such as amiodarone or quinidine, can also enhance the effects of propranolol, increasing the risk of bradycardia, heart block, or other cardiac conduction abnormalities. It is important for prescribers to evaluate the risk-benefit ratio and consider alternative therapies or adjust dosages accordingly.

Propranolol may interact with medications that affect hepatic enzyme activity, such as CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) or inducers (e.g., rifampin, phenytoin). Inhibitors can increase propranolol plasma concentrations, heightening the risk of adverse effects, while inducers may decrease its effectiveness. Regular monitoring and possible dose adjustments are recommended when these drugs are used concurrently.

Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen or naproxen, may reduce the antihypertensive effects of propranolol. Patients should be advised to use these medications cautiously and under medical supervision, especially if they are being treated for hypertension.

Additionally, propranolol can potentiate the hypoglycemic effects of insulin and oral antidiabetic drugs, masking symptoms of hypoglycemia such as tachycardia. Diabetic patients should be counseled on recognizing other signs of low blood sugar and may require more frequent blood glucose monitoring.

Alcohol consumption can enhance the hypotensive effects of propranolol, leading to dizziness or fainting. Patients should be advised to limit alcohol intake and be cautious when standing up quickly from a sitting or lying position.

For both patients and prescribers, it is essential to maintain open communication regarding all medications being taken, including over-the-counter drugs and supplements, to manage potential interactions effectively. If you have any questions or concerns about drug interactions with Propranolol Hydrochloride 10 mg/mL Oral Suspension, please reach out to us for further guidance and support.

How Does it Work

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Propranolol Hydrochloride 10 mg/mL Oral Suspension is a liquid dosage form designed to deliver the active ingredient, propranolol hydrochloride, in a uniform and easily administrable manner. This formulation is particularly beneficial for patients who have difficulty swallowing tablets or require precise dosing adjustments, such as pediatric or geriatric patients. The suspension ensures that the propranolol is evenly distributed throughout the liquid medium, allowing for consistent dosing with each administration.

Propranolol is a non-selective beta-adrenergic receptor blocker, commonly known as a beta-blocker. It works by inhibiting the action of certain natural chemicals in the body, such as epinephrine, on the heart and blood vessels. This action results in a decrease in heart rate, blood pressure, and strain on the heart. By blocking beta-adrenergic receptors, propranolol reduces the heart's workload and helps it to beat more regularly, which is particularly useful in treating conditions such as hypertension, angina, and certain types of arrhythmias.

In addition to cardiovascular conditions, propranolol is also used to manage other disease states. It is effective in reducing the frequency and severity of migraine headaches by preventing the dilation of blood vessels in the brain. Propranolol is also used in the treatment of essential tremor, a neurological disorder that causes involuntary and rhythmic shaking. By modulating the nervous system's response, propranolol can help reduce the amplitude of tremors. Furthermore, it is sometimes prescribed for anxiety, particularly performance anxiety, due to its ability to mitigate the physical symptoms associated with stress, such as rapid heartbeat and trembling.

The oral suspension form of propranolol hydrochloride allows for flexible dosing, which can be crucial for titrating the dose to achieve optimal therapeutic effects while minimizing side effects. The liquid form also facilitates administration in patients who may have difficulty with solid dosage forms, ensuring adherence to prescribed treatment regimens. It is important for both patients and prescribers to understand the pharmacokinetics of propranolol, as it is metabolized primarily by the liver and may interact with other medications. Therefore, careful monitoring and dose adjustments may be necessary to achieve the desired therapeutic outcomes.

If you have any questions about Propranolol Hydrochloride 10 mg/mL Oral Suspension or its use in treating specific conditions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need.

Other Uses

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Propranolol Hydrochloride 10 mg/mL Oral Suspension is primarily used for managing cardiovascular conditions such as hypertension, angina, and arrhythmias. However, this formulation has several other potential uses that may benefit patients with different medical needs. One notable off-label use of propranolol is in the management of anxiety, particularly performance anxiety or situational anxiety, where it helps mitigate the physical symptoms such as rapid heartbeat and tremors. This can be particularly beneficial for individuals who experience anxiety in specific situations like public speaking or performing arts.

Additionally, propranolol has been used in the treatment of migraine prophylaxis. Patients who suffer from frequent migraines may find relief with propranolol, as it can help reduce the frequency and severity of migraine attacks. This can significantly improve the quality of life for individuals who experience debilitating migraines. Furthermore, propranolol has been utilized in the management of essential tremor, a neurological disorder that causes involuntary and rhythmic shaking. By reducing the amplitude of tremors, propranolol can help improve motor function and daily activities for affected individuals.

Propranolol is also sometimes used in the treatment of certain types of thyroid disorders, such as hyperthyroidism, where it helps alleviate symptoms like rapid heart rate and anxiety. In some cases, propranolol may be prescribed for the management of hypertrophic cardiomyopathy, a condition characterized by the thickening of the heart muscle, to help improve heart function and reduce symptoms. Additionally, propranolol has been explored for its potential benefits in treating infantile hemangiomas, a type of benign vascular tumor in infants, where it can help reduce the size and coloration of the hemangiomas.

It is important for both patients and prescribers to be aware of these alternative uses and to consider the potential benefits and risks associated with off-label applications of propranolol. As with any medication, the decision to use propranolol for these other purposes should be based on a thorough evaluation of the patient's medical history, current condition, and treatment goals. If you have any questions or need further information about the use of Propranolol Hydrochloride 10 mg/mL Oral Suspension for these or other conditions, please reach out to us at Bayview Pharmacy. We are here to assist you with any inquiries or concerns you may have regarding this formulation.

Frequently Asked Questions

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What is Propranolol Hydrochloride 10 mg/mL Oral Suspension used for?

Propranolol Hydrochloride Oral Suspension is used to treat high blood pressure, irregular heartbeats, shaking (tremors), and other conditions as determined by your healthcare provider. It works by blocking certain natural chemicals in your body, such as epinephrine, to lower heart rate, blood pressure, and strain on the heart.

How should I take Propranolol Hydrochloride Oral Suspension?

Take the oral suspension exactly as prescribed by your healthcare provider. Shake the bottle well before each use to ensure the medication is evenly distributed. Use a proper measuring device to ensure you are taking the correct dose.

Can I take Propranolol Hydrochloride Oral Suspension with food?

Yes, you can take Propranolol Hydrochloride Oral Suspension with or without food. However, it is best to take it the same way each time to maintain consistent blood levels of the medication.

What should I do if I miss a dose of Propranolol Hydrochloride Oral Suspension?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Are there any side effects associated with Propranolol Hydrochloride Oral Suspension?

Common side effects may include nausea, vomiting, diarrhea, stomach cramps, decreased heart rate, and fatigue. If you experience severe side effects such as difficulty breathing, swelling, or severe dizziness, seek medical attention immediately.

How should I store Propranolol Hydrochloride Oral Suspension?

Store the oral suspension at room temperature, away from light and moisture. Do not freeze. Keep the bottle tightly closed and out of reach of children and pets.

Can I drive or operate machinery while taking Propranolol Hydrochloride Oral Suspension?

Propranolol may cause dizziness or fatigue. Avoid driving or operating heavy machinery until you know how the medication affects you. Consult your healthcare provider if you have concerns about these activities.

Is Propranolol Hydrochloride Oral Suspension safe for children?

The safety and effectiveness of Propranolol Hydrochloride Oral Suspension in children depend on the condition being treated and the child's age and weight. Always follow your healthcare provider's instructions regarding pediatric use.

Can I drink alcohol while taking Propranolol Hydrochloride Oral Suspension?

Alcohol can increase the blood pressure-lowering effects of propranolol, which may lead to dizziness or fainting. It is advisable to limit or avoid alcohol consumption while taking this medication.

What should I do if I experience an allergic reaction to Propranolol Hydrochloride Oral Suspension?

If you experience symptoms of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention. Discontinue use and inform your healthcare provider.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.