Propafenone Hydrochloride 1.5 mg/mL Oral Syrup is a specially compounded medication designed to provide an alternative dosage form for patients who have difficulty swallowing tablets or capsules. Propafenone Hydrochloride is an antiarrhythmic agent used to treat certain types of serious irregular heartbeat conditions, such as paroxysmal atrial fibrillation/flutter and paroxysmal supraventricular tachycardia.

This concentrated liquid formulation contains the active ingredient along with sweeteners to enhance palatability, making it easier to administer orally, particularly for pediatric patients or adults who require a liquid medication. The syrup form

Propafenone Hydrochloride is an antiarrhythmic medication used primarily to treat certain types of serious irregular heartbeats, such as atrial fibrillation, paroxysmal supraventricular tachycardia, and ventricular arrhythmias. It works by stabilizing the heart rhythm, helping to restore a normal heart rate and rhythm. This formulation, as a 1.5 mg/mL oral syrup, is particularly beneficial for pediatric patients or those who have difficulty swallowing tablets or capsules, providing a palatable and easy-to-administer option.

When considering the use of Propafenone Hydrochloride oral syrup, it is crucial to be aware of potential drug interactions that may affect its efficacy or increase the risk of adverse effects. Propafenone is metabolized primarily by the liver enzyme CYP2D6, and to a lesser extent by CYP3A4 and CYP1A2. Therefore, drugs that inhibit or induce these enzymes can significantly alter the plasma concentration of Propafenone, potentially leading to either subtherapeutic effects or increased toxicity.

Strong inhibitors of CYP2D6, such as quinidine, fluoxetine, and paroxetine, can increase the levels of Propafenone, raising the risk of side effects like dizziness, fainting, or arrhythmias. Similarly, inhibitors of CYP3A4, such as ketoconazole, erythromycin, and grapefruit juice, may also elevate Propafenone levels. Conversely, inducers of these enzymes, such as rifampin and phenobarbital, can decrease Propafenone levels, potentially reducing its effectiveness.

Propafenone can also interact with other medications that affect cardiac conduction or have proarrhythmic potential. Concurrent use with other antiarrhythmic agents, such as amiodarone or sotalol, may increase the risk of arrhythmias. Additionally, Propafenone has beta-blocking properties, and its use with other beta-blockers or calcium channel blockers like verapamil and diltiazem can lead to additive effects, such as bradycardia or hypotension.

Patients taking anticoagulants, such as warfarin, should be closely monitored, as Propafenone can increase the anticoagulant effect, necessitating adjustments in the warfarin dose to prevent bleeding complications. Furthermore, Propafenone may enhance the effects of digoxin, leading to digoxin toxicity, so digoxin levels should be monitored, and dose adjustments may be necessary.

It is also important to consider the interaction of Propafenone with local anesthetics used in dental or surgical procedures, as it may potentiate their effects, leading to increased risk of central nervous system and cardiovascular side effects. Patients should inform their healthcare providers, including dentists, about their use of Propafenone syrup before any procedures.

For both patients and prescribers, understanding these potential interactions is essential to ensure safe and effective use of Propafenone Hydrochloride oral syrup. Regular monitoring and communication with healthcare providers can help manage these interactions effectively. If you have any questions or need further information, please reach out to us at Bayview Pharmacy.

Propafenone Hydrochloride 1.5 mg/mL Oral Syrup is a specialized liquid formulation designed to deliver the active ingredient, propafenone hydrochloride, in a palatable and easily administrable form. This formulation is particularly beneficial for pediatric patients or individuals who have difficulty swallowing traditional tablets or capsules. Propafenone is an antiarrhythmic medication that works by affecting the way electrical signals travel through the heart, helping to restore normal heart rhythm and maintain a steady heartbeat. It is primarily used to treat certain types of serious irregular heartbeats, such as atrial fibrillation, atrial flutter, and ventricular arrhythmias.

The mechanism of action of propafenone involves blocking specific ion channels in the heart, particularly sodium channels, which play a crucial role in the conduction of electrical impulses. By inhibiting these channels, propafenone reduces the excitability of cardiac cells and slows down the conduction of electrical signals. This action helps to stabilize the heart's rhythm and prevent abnormal rapid heartbeats. Additionally, propafenone has mild beta-blocking properties, which further contribute to its antiarrhythmic effects by reducing the heart rate and decreasing the force of contraction.

The oral syrup formulation of propafenone hydrochloride is compounded to ensure precise dosing and ease of administration. The syrup is carefully prepared to maintain the stability and efficacy of the active ingredient while incorporating sweeteners and flavoring agents to enhance its taste, making it more acceptable for patients, especially children. This formulation allows for flexible dosing adjustments, which can be particularly important in managing pediatric patients or those with specific dosing requirements due to their medical condition or concurrent medications.

For prescribers, it is essential to consider the individual patient's needs and medical history when prescribing propafenone hydrochloride oral syrup. Monitoring the patient's response to the medication and adjusting the dosage as necessary is crucial to achieving optimal therapeutic outcomes. Patients and caregivers should be educated on the importance of adhering to the prescribed dosing schedule and monitoring for any potential side effects, such as dizziness, fatigue, or gastrointestinal disturbances, which should be reported to the healthcare provider promptly.

If you have any questions or require further information about propafenone hydrochloride 1.5 mg/mL oral syrup, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you with any inquiries or concerns you may have regarding this formulation or its use in treating arrhythmias.

Propafenone Hydrochloride 1.5 mg/mL Oral Syrup is primarily used for the management of certain types of arrhythmias, but it may have other potential applications that could be beneficial for both patients and prescribers to consider. This formulation is particularly advantageous for pediatric patients or those who have difficulty swallowing tablets or capsules, as it provides a palatable and easy-to-administer alternative. Beyond its primary use, this oral syrup may be considered for off-label uses in specific clinical scenarios where the modulation of cardiac rhythm is desired, such as in the management of supraventricular tachycardia or other rhythm disturbances that are not adequately controlled by first-line therapies.

In some cases, Propafenone Hydrochloride may be explored for its potential benefits in patients with conditions that predispose them to arrhythmias, such as certain congenital heart defects or post-operative cardiac surgery patients, where maintaining a stable heart rhythm is crucial. Additionally, its use might be considered in patients with a history of arrhythmias who are undergoing procedures that could provoke arrhythmias, as a preventive measure. The liquid formulation allows for precise dosing adjustments, which can be particularly important in populations with varying metabolic rates, such as children or the elderly, ensuring that therapeutic levels are achieved without exceeding safe dosage limits.

For prescribers, it is important to consider the pharmacokinetic properties of Propafenone Hydrochloride when used in a liquid form, as absorption rates may differ from those of solid dosage forms. Monitoring and dose adjustments may be necessary to achieve optimal therapeutic outcomes. Patients and caregivers should be informed about the importance of adhering to prescribed dosing schedules and the potential side effects, which may include dizziness, taste disturbances, or gastrointestinal discomfort. As with any medication, the decision to use Propafenone Hydrochloride Oral Syrup should be based on a thorough evaluation of the patient's medical history and current health status.

If you have any questions or need further information about the use of Propafenone Hydrochloride 1.5 mg/mL Oral Syrup, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or concerns you may have regarding this formulation.