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Promethazine Hydrochloride 1 mg/mL Oral Syrup

Promethazine Hydrochloride 1 mg/mL Oral Syrup is a concentrated liquid formulation designed for oral administration. It contains active ingredients and sweeteners, providing a palatable and easy-to-administer dosage form. This syrup is particularly beneficial for pediatric patients or individuals who have difficulty swallowing tablets or capsules.

This formulation is used to treat a variety of conditions, including allergies, motion sickness, nausea, and vomiting. It is also effective in managing symptoms of the common cold, such as runny nose and sneezing, and can be used as a sedative or sleep aid.

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Promethazine Hydrochloride
Oral Syrup
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Formula Information

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Promethazine Hydrochloride 1 mg/mL Oral Syrup is a concentrated liquid formulation designed to relieve a variety of symptoms associated with allergies, motion sickness, nausea, and vomiting. As an antihistamine, promethazine works by blocking histamine receptors in the body, which helps reduce symptoms like itching, sneezing, runny nose, and watery eyes.

This palatable syrup is particularly beneficial for pediatric patients or individuals who have difficulty swallowing tablets or capsules. The sweetened liquid formulation not only makes administration easier but also allows for precise dosing tailored to individual needs. The 1 mg/mL concentration provides flexibility in adjusting doses, which is especially important in managing symptoms effectively in different age groups and sensitivities.

In addition to its antihistamine effects, promethazine possesses antiemetic properties that help prevent and control nausea and vomiting. It is often used to alleviate motion sickness and can be administered before travel to reduce the likelihood of discomfort. Furthermore, due to its sedative effects, it may be utilized to promote relaxation or enhance the effectiveness of certain analgesics in managing pain.

Patients should be aware of potential side effects, including drowsiness, dizziness, dry mouth, blurred vision, or constipation. It is important to use this medication under the supervision of a healthcare professional, as promethazine may interact with other medications or may not be suitable for individuals with certain health conditions. Careful monitoring and adherence to prescribed directions can help maximize benefits while minimizing risks.

For prescribers, this compounded oral syrup offers a customizable option to meet specific patient needs. The liquid form ensures better compliance among those who might refuse or have difficulty taking solid medications, thereby improving therapeutic outcomes. Adjustments in flavoring or sweetness can also be made to enhance acceptability, making it a versatile choice in personalized medicine.

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Drug Interactions

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Promethazine Hydrochloride 1 mg/mL Oral Syrup is a concentrated liquid formulation designed for ease of administration, particularly in pediatric patients or those who have difficulty swallowing tablets or capsules. This formulation is commonly used to treat conditions such as allergies, motion sickness, nausea, and vomiting, and it may also be used as a sedative or sleep aid. However, it is important to be aware of potential drug interactions that could affect the efficacy and safety of this medication.

Promethazine is a phenothiazine derivative with antihistaminic, sedative, and antiemetic properties. It can interact with a variety of medications, leading to increased side effects or reduced therapeutic effects. One of the primary concerns is its interaction with central nervous system (CNS) depressants, such as alcohol, benzodiazepines, barbiturates, and opioids. Concurrent use of these substances can enhance the sedative effects of promethazine, potentially leading to profound sedation, respiratory depression, or even coma. Patients should be advised to avoid or limit the use of alcohol and other CNS depressants while taking this medication.

Promethazine may also interact with other medications that have anticholinergic properties, such as tricyclic antidepressants, antipsychotics, and certain antihistamines. The combination of these drugs can increase the risk of anticholinergic side effects, including dry mouth, constipation, urinary retention, and blurred vision. Patients should be monitored for these effects, and prescribers should consider adjusting the dosage or selecting alternative therapies if necessary.

Additionally, promethazine can affect the metabolism of other drugs by inhibiting cytochrome P450 enzymes, particularly CYP2D6. This can lead to increased plasma concentrations of drugs metabolized by this pathway, such as certain beta-blockers, antidepressants, and antipsychotics, potentially resulting in enhanced effects or toxicity. It is important for prescribers to review the patient's medication profile for potential interactions and adjust dosages accordingly.

Patients with cardiovascular conditions should be cautious when using promethazine, as it can interact with medications that affect heart rhythm, such as antiarrhythmics and certain antibiotics. Promethazine may prolong the QT interval, increasing the risk of arrhythmias. Regular monitoring of cardiac function and electrolyte levels is recommended for patients at risk.

For patients with diabetes, it is important to note that promethazine may interfere with glucose control. It can mask the symptoms of hypoglycemia, such as dizziness and sweating, making it more difficult to recognize and treat low blood sugar levels. Patients should be advised to monitor their blood glucose levels closely and report any unusual symptoms to their healthcare provider.

In summary, while Promethazine Hydrochloride 1 mg/mL Oral Syrup is an effective treatment for various conditions, it is crucial to consider potential drug interactions that may impact its safety and efficacy. Patients and prescribers should work closely to review all medications and supplements being taken to minimize the risk of adverse interactions. If you have any questions or concerns about drug interactions with this formulation, please reach out to us for further assistance.

How Does it Work

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Promethazine Hydrochloride 1 mg/mL Oral Syrup is a specially formulated liquid medication designed to deliver the active ingredient, promethazine hydrochloride, in a palatable and easily administered form. This formulation is particularly beneficial for pediatric patients or individuals who have difficulty swallowing tablets or capsules, ensuring they receive the necessary medication in a manner that is both effective and convenient.

Promethazine hydrochloride is an antihistamine that works by blocking the action of histamine, a substance in the body that causes allergic symptoms. It is commonly used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. Additionally, promethazine is effective in preventing and treating nausea and vomiting related to certain conditions, such as motion sickness or post-operative recovery. It can also be used as a sedative or sleep aid, due to its ability to produce a calming effect on the central nervous system.

The oral syrup formulation allows for precise dosing, which is crucial in managing the symptoms effectively while minimizing potential side effects. The concentration of 1 mg/mL ensures that the dosage can be easily adjusted according to the specific needs of the patient, as determined by the healthcare provider. This flexibility is particularly important in pediatric care, where dosing often needs to be tailored to the child's weight and age.

In addition to the active ingredient, the syrup contains sweeteners and flavoring agents to enhance its taste, making it more acceptable to children and adults alike. This is an important consideration, as a pleasant-tasting medication is more likely to be taken consistently, thereby improving adherence to the prescribed treatment regimen.

For prescribers, this formulation offers a reliable and versatile option for managing a range of conditions associated with histamine activity and nausea. It is important to consider the patient's overall health status, potential drug interactions, and specific needs when prescribing this medication. As with any medication, monitoring for side effects and adjusting the dosage as necessary is essential to ensure optimal therapeutic outcomes.

If you have any questions about Promethazine Hydrochloride 1 mg/mL Oral Syrup or need further information on its use, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or concerns you may have.

Other Uses

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Promethazine Hydrochloride 1 mg/mL Oral Syrup is primarily known for its use in treating allergies, motion sickness, nausea, and vomiting, as well as being a sedative or sleep aid. However, this formulation has several other potential applications that may be beneficial for both patients and prescribers to consider. One such use is in the management of anxiety and tension, particularly in patients who may experience these symptoms as a result of other medical conditions or treatments. The sedative properties of promethazine can help alleviate mild anxiety, providing a calming effect that can be particularly useful in preoperative settings or for patients undergoing stressful medical procedures.

Additionally, promethazine syrup can be used as an adjunct therapy in the management of pain. While it is not an analgesic itself, its sedative effects can enhance the efficacy of pain medications, making it a valuable component of a comprehensive pain management plan. This can be particularly beneficial for patients who are experiencing pain-related insomnia, as the syrup can help improve sleep quality, thereby aiding in overall recovery and well-being.

In certain cases, promethazine syrup may also be used to manage symptoms of vertigo. By addressing the nausea and dizziness associated with this condition, the syrup can help improve patient comfort and quality of life. Furthermore, its liquid form makes it an ideal option for pediatric patients or those with swallowing difficulties, ensuring that they receive the necessary medication in a form that is both palatable and easy to administer.

For patients with chronic respiratory conditions, promethazine syrup can be used to alleviate symptoms such as cough and congestion. Its antihistamine properties can help reduce mucus production and provide relief from respiratory discomfort. However, it is important for prescribers to carefully consider the patient's overall health status and any potential contraindications before recommending this use.

As with any medication, it is crucial for both patients and prescribers to be aware of potential side effects and interactions with other medications. Promethazine can cause drowsiness, dizziness, and dry mouth, among other side effects, and may interact with other central nervous system depressants. Therefore, it is important to use this medication under the guidance of a healthcare professional. If you have any questions or need further information about the use of Promethazine Hydrochloride 1 mg/mL Oral Syrup, please reach out to us at Bayview Pharmacy. We are here to assist you with any inquiries or concerns you may have.

Frequently Asked Questions

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What is Promethazine Hydrochloride 1 mg/mL Oral Syrup used for?

Promethazine Hydrochloride 1 mg/mL Oral Syrup is used to treat allergy symptoms, nausea, and vomiting, and to provide sedation. It is often prescribed for patients who have difficulty swallowing tablets or capsules, such as children or the elderly.

How should I take Promethazine Hydrochloride Oral Syrup?

Promethazine Hydrochloride Oral Syrup should be taken by mouth, using a proper measuring device to ensure the correct dosage. Follow your healthcare provider's instructions regarding the dosage and frequency.

Can children take Promethazine Hydrochloride Oral Syrup?

Yes, this syrup is often used in pediatric populations due to its palatable taste and ease of administration. However, it should only be given to children under the guidance of a healthcare provider.

Are there any side effects associated with Promethazine Hydrochloride Oral Syrup?

Common side effects may include drowsiness, dizziness, dry mouth, and blurred vision. If you experience severe side effects or signs of an allergic reaction, seek medical attention immediately.

Can I take Promethazine Hydrochloride Oral Syrup with other medications?

Before taking this syrup, inform your healthcare provider about any other medications you are taking, as there may be potential interactions. Your provider will advise you on safe use.

How should I store Promethazine Hydrochloride Oral Syrup?

Store the syrup at room temperature, away from light and moisture. Keep it out of reach of children and pets to prevent accidental ingestion.

What should I do if I miss a dose of Promethazine Hydrochloride Oral Syrup?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Is Promethazine Hydrochloride Oral Syrup safe during pregnancy?

If you are pregnant or planning to become pregnant, consult your healthcare provider before using this medication to discuss potential risks and benefits.

Can I drive or operate machinery after taking Promethazine Hydrochloride Oral Syrup?

This medication may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how the medication affects you.

What should I do in case of an overdose of Promethazine Hydrochloride Oral Syrup?

In case of an overdose, seek emergency medical attention immediately. Symptoms of overdose may include severe drowsiness, confusion, and difficulty breathing.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.