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Formulas

Pimobendan 10 mg Oral Capsules

Pimobendan 10 mg Oral Capsules are a solid dosage form consisting of two halves of either gelatin or vegetarian-based shells that encapsulate the active medication. This design ensures the capsules are easy to swallow and that each dose contains an exact amount of the active ingredient, pimobendan. Pimobendan is primarily used in the treatment of certain types of heart failure, including congestive heart failure (CHF) caused by either dilated cardiomyopathy or valvular insufficiency in dogs. By improving myocardial contractility and dilating blood vessels, it helps to increase cardiac output and reduce the heart's workload.

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Pimobendan Hydrochloride
Capsules
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Formula Information

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Pimobendan 10 mg Oral Capsules are a solid dosage form consisting of two halves of either gelatin or vegetarian-based shells that encapsulate the active medication. This form of medication is designed to be swallowed easily and to ensure that patients receive an exact dose of Pimobendan with each administration. Pimobendan is a positive inotropic drug, which means it increases the strength of the heart's contractions and improves its pumping efficiency. It also possesses vasodilating properties, leading to a reduction in the workload of the heart by decreasing the resistance the heart must overcome to eject blood.

This medication is primarily used in the treatment of certain types of heart failure in dogs, such as congestive heart failure (CHF) caused by mitral valve disease or dilated cardiomyopathy. By improving cardiac output and reducing the heart's workload, Pimobendan helps to alleviate the symptoms associated with these disease states, such as difficulty breathing, fatigue, and coughing. It is important to note that while Pimobendan is not a cure for heart disease, it can significantly improve the quality of life for affected animals and may extend their lifespan.

For prescribers, it is crucial to consider the specific cardiac condition being treated and to ensure that Pimobendan is appropriate for the patient's current stage of heart disease. The dosage and administration of Pimobendan should be tailored to the individual needs of the patient, and it is typically given orally twice a day about an hour before food. Monitoring for potential side effects, such as gastrointestinal upset or changes in heart rate, is recommended. As with any medication, it is essential to consult with a veterinarian before starting treatment with Pimobendan to determine if it is suitable for a particular patient.

Patients and prescribers looking to use Pimobendan 10 mg Oral Capsules can trust that Bayview Pharmacy provides a high-quality, accurately compounded formulation. Our team of knowledgeable compounding pharmacists is dedicated to ensuring the safety and efficacy of our medications. Should you have any questions or require further information about Pimobendan capsules or their use in treating heart conditions, please do not hesitate to reach out to us. We are here to support both patients and healthcare providers with expert advice and comprehensive care.

Drug Interactions

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Pimobendan is a positive inotropic drug that works by increasing the sensitivity of the heart's myofilaments to calcium, which enhances cardiac output and reduces the heart's workload. It is commonly used in the treatment of certain types of heart failure in dogs, such as congestive heart failure due to dilated cardiomyopathy or valvular insufficiency. While pimobendan is beneficial for managing these conditions, it is important to be aware of potential drug interactions when it is prescribed.

Patients taking pimobendan should be cautious about concomitant use with beta-blockers, such as atenolol or propranolol, as these medications can negate the positive inotropic effects of pimobendan. If beta-blockers are necessary, careful monitoring and dose adjustments may be required. Additionally, the use of pimobendan with calcium channel blockers like diltiazem, which also have negative inotropic effects, should be avoided or closely monitored for reduced therapeutic efficacy of pimobendan.

Concurrent use of pimobendan with other positive inotropes, such as digoxin, should be approached with caution due to the potential for additive inotropic and chronotropic effects, which could lead to arrhythmias. Serum digoxin levels should be monitored, and the dose may need to be adjusted. Pimobendan may also enhance the anticoagulant effect of drugs like warfarin, and thus, coagulation parameters should be closely monitored, and the dose of the anticoagulant may need to be modified.

Phosphodiesterase (PDE) inhibitors, such as sildenafil, can have additive vasodilatory effects when used with pimobendan, potentially leading to hypotension. Careful monitoring of blood pressure is advised when these drugs are used concurrently. Additionally, pimobendan should be used with caution in animals receiving other vasodilators, such as ACE inhibitors, due to the potential for hypotension and syncope.

It is also important to consider that pimobendan is metabolized by the liver, and drugs that affect hepatic enzymes could potentially alter the metabolism of pimobendan. For example, drugs that induce liver enzymes may decrease pimobendan levels, while those that inhibit liver enzymes may increase pimobendan levels, potentially leading to toxicity.

Lastly, as with any medication, the potential for allergic reactions or idiosyncratic drug reactions exists, and any signs of adverse effects should be reported to a veterinarian immediately. It is crucial for prescribers to review the patient's complete medication list, including over-the-counter drugs and supplements, to identify and manage any potential interactions with pimobendan.

For more detailed information on drug interactions with pimobendan or if you have any questions regarding this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of pimobendan in your patients.

How Does it Work

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Pimobendan is a medication that is primarily used to treat certain types of heart failure in dogs, such as congestive heart failure (CHF) resulting from dilated cardiomyopathy or valvular insufficiency. It is a positive inotrope, which means it increases the strength of the heart's contractions, and a vasodilator, which means it relaxes the blood vessels, reducing the workload on the heart. Pimobendan works by inhibiting phosphodiesterase III (PDE3) and increasing the sensitivity of cardiac myofilaments to calcium, which enhances the heart's ability to pump blood more effectively. Additionally, by dilating the blood vessels, it decreases the resistance the heart must overcome to eject blood, which helps to alleviate symptoms associated with CHF such as difficulty breathing, coughing, and fatigue.

The Pimobendan 10 mg Oral Capsules are a solid dosage form that provides a precise dose of the active ingredient, pimobendan. These capsules are composed of two halves, either gelatin or vegetarian-based, that are joined together to enclose the medication. This form of encapsulation is designed to make the medication easy to swallow and to protect the active ingredient from degradation or damage before it reaches the stomach. Once ingested, the capsule shell dissolves, releasing the pimobendan for absorption into the bloodstream. The use of capsules ensures a consistent and accurate dosage, which is crucial for managing heart conditions effectively.

For patients and prescribers considering the use of Pimobendan 10 mg Oral Capsules, it is important to understand that this medication should only be used under the guidance of a veterinarian, as it is specifically formulated for veterinary use. The dosage and duration of treatment will depend on the severity of the heart condition and the response to therapy. Regular monitoring by a veterinarian is essential to adjust the dosage as needed and to assess the effectiveness of the treatment. It is also important to be aware of potential side effects, which may include gastrointestinal upset, lethargy, or changes in heart rate or rhythm.

If you have any questions about Pimobendan 10 mg Oral Capsules or their use in treating heart conditions in dogs, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to ensure the best possible care for your pet.

Other Uses

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Pimobendan, primarily known for its veterinary use, is classified as an inodilator, which means it has both inotropic and vasodilating effects. While it is most commonly prescribed for dogs with congestive heart failure, particularly due to mitral valve disease or dilated cardiomyopathy, research on its potential applications in human medicine had been emerging before our knowledge cutoff. In humans, it has been studied and occasionally used in cases of heart failure where it improves myocardial contractility and reduces the workload on the heart by dilating blood vessels. This can lead to improved cardiac output and reduction of symptoms associated with heart failure.

Apart from its cardiovascular indications, there are ongoing investigations into the potential repurposing of pimobendan for other medical uses. For instance, its vasodilatory effects have made it a candidate for studying in the context of pulmonary hypertension and other diseases characterized by elevated blood pressure in the lungs. It is important to note that such uses are not standard and should be considered experimental. Furthermore, as is the case with any medication being repurposed or used off-label, clinicians must carefully weigh the available evidence and consider patient-specific factors before prescribing pimobendan for non-standard indications.

In the formulation of pimobendan 10 mg oral capsules, the solid dosage form provides advantages such as ease of administration, consistency of dosing, and stability of the active ingredient. The encapsulation within gelatin or vegetarian shells may also reduce the potential for degradation by environmental factors and ensure a precise delivery of the medication to the site of action. This form of pimobendan is suitable for those who might have difficulty swallowing tablets or for whom liquid formulations are inconvenient.

It's important for patients and prescribers to stay informed about the latest developments and research relating to off-label uses of medications like pimobendan. Any other uses of this medication should be discussed with a healthcare provider. If you have any questions or require further details on the potential applications or mechanisms of pimobendan, please feel free to reach out to us at Bayview Pharmacy. Our compounding pharmacy team is dedicated to providing in-depth information and personalized care to ensure the safe and effective use of all medications.

Frequently Asked Questions

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What is Pimobendan 10 mg Oral Capsules?

Pimobendan 10 mg Oral Capsules are a prescription medication used to treat certain heart conditions such as congestive heart failure. They are solid dosage forms comprising two gelatin or vegetarian shells that encase the exact dose of the active ingredient, Pimobendan, making them easy to swallow.

How should I take Pimobendan 10 mg Oral Capsules?

Take Pimobendan 10 mg Oral Capsules exactly as prescribed by your veterinarian. You should not chew or crush the capsules but swallow them whole with water. It's crucial to follow the dosing schedule provided by your vet.

Can I open the Pimobendan capsules and mix them with food?

No, you should not open the capsules. Pimobendan 10 mg Oral Capsules are designed to be taken whole to ensure the precise dosage is administered. Opening the capsule could result in an incorrect dose and reduced effectiveness of the medication.

Are there any potential side effects of taking Pimobendan 10 mg Oral Capsules?

As with all medications, Pimobendan can cause side effects. Common side effects may include lack of appetite, diarrhea, difficulty breathing, and lethargy. If you notice any severe or concerning symptoms, you should contact your veterinarian immediately.

What should I do if I miss a dose of Pimobendan 10 mg Oral Capsules?

If you miss a dose, give it as soon as you remember, unless it is almost time for the next dose. In that case, skip the missed dose and continue with the regular dosing schedule. Do not double up on doses to make up for the one you missed.

How should I store Pimobendan 10 mg Oral Capsules?

Store Pimobendan 10 mg Oral Capsules at room temperature, away from direct light, moisture, and heat. Keep the capsules in their original container and out of reach of children and pets.

Can Pimobendan 10 mg Oral Capsules be given with other medications?

Pimobendan may interact with other medications. It is important to inform your veterinarian about all medications and supplements your pet is taking before starting Pimobendan. Your vet will advise you on the safety of using it with other drugs.

Do I need a prescription to purchase Pimobendan 10 mg Oral Capsules?

Yes, Pimobendan 10 mg Oral Capsules are a prescription medication, and you will need a valid prescription from your veterinarian to purchase them.

Are the shells of Pimobendan 10 mg Oral Capsules safe for pets with dietary restrictions?

The shells of these capsules are typically made from gelatin or a vegetarian alternative. If your pet has specific dietary restrictions or allergies, consult your veterinarian to ensure the capsule components are safe for your pet.

Can Pimobendan 10 mg Oral Capsules be used for all breeds of dogs?

Pimobendan is used for dogs with specific heart conditions and may not be safe or appropriate for all breeds or health conditions. The suitability of Pimobendan for your dog should be assessed by a veterinarian based on your dog’s specific medical needs.

How long does treatment with Pimobendan 10 mg Oral Capsules typically last?

The duration of treatment with Pimobendan 10 mg Oral Capsules will depend on your pet's condition and response to the medication. It's crucial to follow your veterinarian's guidance and not to stop the medication without consulting them, even if your pet seems better.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.