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Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
Prepared to a prescriber's order for one patient. Not FDA-approved.
This is a compounded troche containing pilocarpine hydrochloride, prepared to a prescriber's order for one patient. Compounded preparations are not FDA-approved.
These listings cover every salt or ester form of each drug in the FDA National Drug Code Directory.
FDA-approved products containing pilocarpine are listed in tablet and solution forms. No finished pilocarpine product of any kind is listed in troche form.
Bases for this dose form differ, and the base used decides how USP <795> classifies the preparation for beyond-use dating. The date printed on the label is the one to follow.
Pilocarpine is a cholinergic (muscarinic) agonist that compounding pharmacies prepare as sterile eye drops, oral capsules and oral liquids by prescription.
Pilocarpine is a cholinergic drug that stimulates muscarinic receptors, the same receptors the nerve messenger acetylcholine acts on. In the eye it constricts the pupil and lowers eye pressure; by mouth it stimulates salivary and sweat glands. Salagen tablets (Advanz) are FDA-approved for dry mouth from salivary gland damage caused by radiation for head and neck cancer, and for dry mouth in Sjogren's syndrome. Pilocarpine hydrochloride ophthalmic solution (for example Somerset) is approved to lower raised eye pressure in open-angle glaucoma or ocular hypertension, manage acute angle-closure glaucoma, prevent pressure spikes after laser surgery and constrict the pupil. Qlosi (Orasis) eye drops are approved for presbyopia in adults. A prescriber may order pilocarpine compounded in a strength, dosage form or preservative-free vehicle that is not manufactured. Compounded preparations are not FDA-approved and require a prescription.
Pilocarpine does not carry a boxed warning. Salagen tablets should not be used with uncontrolled asthma, a pilocarpine allergy, or when pupil constriction is undesirable, such as acute iritis or narrow-angle glaucoma. Pilocarpine can blur vision and dim night vision, so take care driving at night or in poor light. Eye drop labels advise a retinal exam before starting, because rare retinal detachments have been reported. By mouth it can cause heavy sweating and dehydration, nausea, runny nose, diarrhea, dizziness, and a fast or slow heartbeat; people with significant heart disease, asthma or lung disease need close supervision. Use caution with beta-blockers because of heart conduction effects; it adds to other cholinergic drugs and may oppose anticholinergic drugs. LactMed reports no harm from eye drops in limited data but no information for oral use. For vision changes or a slow heartbeat, talk to your prescriber or pharmacist.
Pilocarpine is a muscarinic agonist with full and partial agonism at the M3 receptor; Gq-mediated phospholipase C activation raises intracellular calcium and contracts smooth muscle such as the pupillary sphincter, and it stimulates salivary and other exocrine glands. Per the Salagen label, oral elimination half-life is short, about 0.76 to 1.35 hours, and mild to moderate hepatic impairment roughly doubles exposure. StatPearls (archived) describes CYP2A6-mediated 3-hydroxylation and paraoxonase 1 hydrolysis to inactive metabolites, with mainly urinary excretion. Labeled indications: xerostomia after head and neck radiation and in Sjogren's syndrome (Salagen); open-angle glaucoma, ocular hypertension, acute angle-closure glaucoma, post-laser pressure prevention and miosis (pilocarpine ophthalmic solution); presbyopia (Qlosi). StatPearls states there are no off-label indications. Dosing and strength per prescriber. Monitor for cholinergic excess (sweating, salivation, lacrimation, diarrhea, bradycardia, bronchospasm), heart rate in cardiovascular disease, hydration, and with ophthalmic use intraocular pressure and a baseline retinal examination. There is no known antidote, so management is dose reduction or discontinuation. Pilocarpine is not a controlled substance.
Wash and dry your hands. Place the troche between your cheek and gum or under your tongue, as your label directs, and let it dissolve. Do not chew or swallow it whole unless told to. Dissolving can take up to 30 minutes. Follow your label about eating or drinking around the dose.
Troches are nonaqueous, so a USP <795> default beyond-use date of up to 180 days usually applies. Store in the closed container in a cool, dry place at room temperature, away from heat so they do not soften, and out of reach of children. Discard after the beyond-use date on the label.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.
Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Place 1 troche between cheek and gum and let slowly dissolve
