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Formulas

Metronidazole 100 mg/g Topical Ointment

Metronidazole 100 mg/g Topical Ointment is a semi-solid formulation dispensed in a tube, designed for external application to the skin. It features a greasy or oily base that enhances the delivery of the active medication, metronidazole, directly to the affected area. This ointment is primarily used for the localized treatment of skin conditions such as rosacea, bacterial skin infections, and certain types of dermatitis. Its formulation is particularly effective in reducing inflammation, combating infection, and promoting wound healing.

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Metronidazole
Topical Ointment
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Formula Information

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Metronidazole 100 mg/g Topical Ointment is a semi-solid formulation designed for external application to the skin. Dispensed in a tube, this ointment provides a greasy or oily base that aids in delivering the medication directly to the affected area. The formulation allows for localized treatment, making it particularly useful for managing skin conditions that benefit from both antimicrobial and anti-inflammatory actions.

Metronidazole is an antibiotic and antiprotozoal agent effective against a variety of anaerobic bacteria and certain parasites. When applied topically, it works by inhibiting the growth of bacteria and reducing inflammation, which can help alleviate symptoms associated with skin infections. The ointment's base not only facilitates the absorption of metronidazole into the skin but also helps maintain moisture, promoting an optimal environment for healing.

This topical ointment is often utilized in treating skin conditions such as inflammatory lesions, bacterial skin infections, or wounds requiring antibiotic intervention. Its high concentration allows for a potent local effect while minimizing systemic absorption. The ointment's greasy nature also provides a protective barrier on the skin, which can be beneficial in protecting wounds from external contaminants.

For patients, it is important to use this medication exactly as prescribed by a healthcare professional. Before application, the affected area should be cleaned and dried thoroughly. A thin layer of the ointment should be gently applied to the skin, usually once

Drug Interactions

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Metronidazole 100 mg/g topical ointment is a potent antimicrobial agent used primarily for the treatment of skin conditions such as inflammation, infections, and wound healing. As a topical formulation, it is designed for external application, providing localized treatment with minimal systemic absorption. However, it is important to be aware of potential drug interactions, even with topical applications, to ensure safe and effective use.

While systemic absorption of metronidazole from topical application is generally low, it is still possible for interactions to occur, particularly in cases of prolonged use or application over large surface areas. Patients using this ointment should inform their healthcare provider of all medications they are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements, to assess any potential interactions.

One of the primary concerns with metronidazole is its interaction with alcohol. Although the risk is lower with topical use compared to oral administration, patients should be advised to avoid alcohol consumption during treatment and for at least 48 hours after discontinuation. This is due to the potential for a disulfiram-like reaction, which can cause symptoms such as flushing, nausea, vomiting, and headache.

Metronidazole may also interact with anticoagulants such as warfarin, potentially enhancing their effects and increasing the risk of bleeding. Although this interaction is more relevant to systemic use, caution is advised, and monitoring of coagulation parameters may be necessary if the patient is on anticoagulant therapy.

Patients using other topical medications or products on the same area of skin should consult their healthcare provider to avoid potential interactions that could affect the efficacy or safety of the treatment. For instance, concurrent use of other topical antibiotics or corticosteroids may alter the absorption or effectiveness of metronidazole.

In rare cases, metronidazole can cause peripheral neuropathy, especially with prolonged use. Patients should be monitored for symptoms such as numbness, tingling, or pain in the extremities, and should report any such symptoms to their healthcare provider promptly.

For prescribers, it is crucial to evaluate the patient's complete medication profile and medical history before prescribing metronidazole topical ointment. Consideration should be given to the potential for systemic absorption and interactions, particularly in patients with compromised skin barriers or those requiring long-term treatment.

If you have any questions or need further information regarding the use of metronidazole 100 mg/g topical ointment and its potential interactions, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

How Does it Work

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Metronidazole 100 mg/g topical ointment is a specialized formulation designed for external application to the skin, providing targeted treatment for various dermatological conditions. This semi-solid ointment is dispensed in a tube, making it convenient for precise application to affected areas. The formulation utilizes a greasy or oily base, which not only facilitates the delivery of the active ingredient, metronidazole, but also helps in maintaining skin moisture and creating a protective barrier over the skin. This barrier aids in the retention of the medication on the skin surface, ensuring prolonged contact and enhanced absorption of the active compound.

Metronidazole is an antibiotic and antiprotozoal agent that works by inhibiting the nucleic acid synthesis of microorganisms, leading to their death. When applied topically, metronidazole is effective against a variety of anaerobic bacteria and certain parasites, making it particularly useful in treating skin infections and conditions characterized by inflammation and bacterial overgrowth. The ointment's formulation allows for localized treatment, minimizing systemic absorption and reducing the risk of systemic side effects, which is a significant advantage for patients requiring long-term therapy.

This topical ointment is commonly used to treat conditions such as rosacea, acne, and other inflammatory skin disorders where bacterial infection is a contributing factor. By reducing the bacterial load and inflammation, metronidazole helps in alleviating symptoms such as redness, swelling, and discomfort. Additionally, the ointment's emollient properties aid in wound healing by keeping the skin hydrated and protected, which is crucial for the repair and regeneration of damaged tissues.

For prescribers, it is important to consider the specific needs of the patient, including the severity and location of the condition, when recommending metronidazole topical ointment. The formulation's greasy base may not be suitable for all skin types, particularly for patients with oily skin, and alternative formulations may be considered in such cases. Patients should be advised to apply the ointment as directed, typically in a thin layer over the affected area, and to avoid contact with the eyes and mucous membranes.

Overall, metronidazole 100 mg/g topical ointment offers a targeted and effective treatment option for various skin conditions, with the added benefit of a formulation that supports skin health and healing. If you have any questions or need further information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries you may have.

Other Uses

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Metronidazole 100 mg/g topical ointment, primarily used for treating skin inflammation, infections, and wound healing, has several other potential applications that may be of interest to both patients and prescribers. This formulation, with its semi-solid consistency and greasy or oily base, is particularly effective in delivering medication directly to the affected area, ensuring localized treatment with minimal systemic absorption. Beyond its primary uses, metronidazole ointment can be beneficial in managing certain dermatological conditions characterized by bacterial or protozoal infections, such as rosacea, where it helps reduce redness and inflammation. Additionally, it may be used off-label for conditions like perioral dermatitis, a facial rash that often requires topical antibiotics for effective management.

In some cases, metronidazole ointment is employed in the treatment of malodorous wounds, particularly those infected with anaerobic bacteria, due to its ability to target these specific pathogens. This can be especially useful in palliative care settings, where managing wound odor significantly improves patient comfort and quality of life. Furthermore, the ointment's formulation is advantageous for patients with dry or sensitive skin, as the greasy base provides a protective barrier that helps retain moisture and promote healing.

For prescribers considering metronidazole ointment for off-label uses, it is important to evaluate the specific needs of the patient and the nature of the condition being treated. The ointment's localized action minimizes systemic side effects, making it a suitable option for patients who may not tolerate oral antibiotics well. However, as with any medication, it is crucial to monitor for potential allergic reactions or skin irritation, particularly in patients with a history of hypersensitivity to metronidazole or similar compounds.

Patients using metronidazole ointment should be advised on the proper application technique to maximize its therapeutic benefits. This includes applying a thin layer to the affected area, avoiding contact with the eyes, and washing hands thoroughly after use. Consistent application as directed by a healthcare provider is key to achieving optimal results. If you have any questions or need further information about the use of metronidazole 100 mg/g topical ointment, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to assist you with any inquiries or concerns you may have.

Frequently Asked Questions

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What is Metronidazole 100 mg/g Topical Ointment used for?

Metronidazole 100 mg/g Topical Ointment is used for the treatment of skin conditions such as inflammation, infections, or wound healing. It is designed for external application to the skin to deliver medication directly to the affected area.

How should I apply Metronidazole 100 mg/g Topical Ointment?

Apply a thin layer of the ointment to the affected area of the skin as directed by your healthcare provider. Make sure to wash your hands before and after application, unless the treatment is for your hands.

Can I use Metronidazole 100 mg/g Topical Ointment on open wounds?

Consult your healthcare provider before applying the ointment to open wounds. It is generally used for localized treatment of skin conditions, but your provider will give specific instructions based on your condition.

Are there any side effects associated with Metronidazole 100 mg/g Topical Ointment?

Some people may experience mild side effects such as skin irritation, redness, or itching at the application site. If you experience severe reactions or symptoms persist, contact your healthcare provider.

How often should I use Metronidazole 100 mg/g Topical Ointment?

The frequency of application will depend on your specific condition and the instructions provided by your healthcare provider. Follow their guidance carefully for optimal results.

Can I use Metronidazole 100 mg/g Topical Ointment with other topical medications?

Before using other topical medications in conjunction with Metronidazole ointment, consult your healthcare provider to avoid potential interactions or reduced effectiveness.

Is Metronidazole 100 mg/g Topical Ointment safe for children?

Consult a healthcare provider before using this ointment on children, as they will provide guidance based on the child's specific condition and needs.

What should I do if I miss a dose of Metronidazole 100 mg/g Topical Ointment?

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra to make up for a missed dose.

How should I store Metronidazole 100 mg/g Topical Ointment?

Store the ointment at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets.

Can I use Metronidazole 100 mg/g Topical Ointment during pregnancy or breastfeeding?

If you are pregnant or breastfeeding, consult your healthcare provider before using this ointment to ensure it is safe for you and your baby.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.