Lidocaine HCl 120 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum, where it dissolves or melts to release the active medication, lidocaine hydrochloride, for local or systemic absorption. Lidocaine is a local anesthetic and antiarrhythmic drug that works by blocking sodium channels, which in turn stabilizes the neuronal membrane and inhibits the initiation and conduction of nerve impulses. This action provides a local anesthetic effect, offering relief from pain and discomfort.

This particular formulation is used primarily for its local anesthetic properties in the rectal area. It can be beneficial in managing symptoms associated with hemorrhoids, anal fissures, and other anorectal disorders by providing temporary relief from pain, itching, and discomfort. Additionally, it may be used before or after rectal examinations or surgeries to alleviate pain. The 120 mg dose of Lidocaine HCl in each suppository ensures that a sufficient amount of the drug is available at the site of action to provide effective analgesia.

For patients, it is important to understand that while lidocaine provides symptomatic relief, it does not treat the underlying cause of the anorectal conditions. Proper use of the suppository involves inserting it into the rectum as directed by a healthcare provider, usually not more than 2 to 4 times daily. Patients should be advised to wash their hands before and after use, and to avoid using the suppository if the rectal area is injured or infected unless directed by a physician.

Prescribers should consider the patient's overall medical condition, including any history of heart disease or liver dysfunction, as lidocaine is metabolized in the liver and has the potential to cause systemic effects, particularly when used in higher doses or more frequently than recommended. It is also important to review any concurrent medications the patient is taking to avoid potential drug interactions. As with any medication, allergic reactions to lidocaine, although rare, should be considered, and patients should be instructed to seek immediate medical attention if they experience symptoms of an allergic reaction.

Bayview Pharmacy's team of compounding pharmacists ensures that each Lidocaine HCl 120 mg Rectal Suppository is prepared to the highest standards of quality and safety. We are available to answer any questions or concerns from both patients and prescribers regarding this formulation. Our goal is to provide effective pain management solutions tailored to individual patient needs. If you have any questions or require further information, please do not hesitate to reach out to us.

Lidocaine HCl is a local anesthetic commonly used to provide temporary relief of pain and discomfort in various conditions such as hemorrhoids, anal fissures, and after rectal surgeries. When formulated as a 120 mg rectal suppository, lidocaine works by blocking nerve signals in the body, which helps to numb the rectal area. While lidocaine is generally safe and effective when used as directed, it is important to be aware of potential drug interactions that could affect its efficacy or increase the risk of adverse effects.

One of the primary concerns with lidocaine is its potential interaction with other local anesthetics or medications that affect cardiac conduction. Combining lidocaine with other local anesthetics may increase the risk of systemic toxicity, which can lead to symptoms such as dizziness, tremors, seizures, and cardiac arrhythmias. Patients should inform their healthcare provider of all the medications they are currently taking, including over-the-counter drugs and herbal supplements, to avoid such interactions.

Patients taking antiarrhythmic drugs, such as amiodarone or beta-blockers, should use lidocaine with caution. These medications can affect cardiac conduction and potentiate the effects of lidocaine, potentially leading to an increased risk of bradycardia, heart block, or cardiac arrest. Close monitoring by a healthcare provider is recommended when these drugs are used concurrently with lidocaine suppositories.

Additionally, lidocaine is metabolized by the liver, and drugs that affect hepatic enzyme activity, particularly cytochrome P450 isoenzymes, can alter the metabolism of lidocaine. For example, medications that inhibit CYP1A2, CYP3A4, and CYP2D6 enzymes may increase lidocaine levels in the body, leading to an increased risk of toxicity. Conversely, drugs that induce these enzymes may decrease lidocaine levels, reducing its efficacy. Patients with liver impairment may also be at increased risk of lidocaine toxicity due to reduced metabolism and clearance of the drug.

It is also important to consider the potential for additive central nervous system (CNS) depression when lidocaine is used with other CNS depressants, such as opioids, benzodiazepines, or alcohol. This combination can lead to increased sedation, respiratory depression, and other CNS side effects. Patients should avoid or limit the use of alcohol and other CNS depressants while using lidocaine suppositories unless specifically directed by their healthcare provider.

Lastly, since lidocaine is used for local anesthetic purposes, it is important to ensure that the patient does not have a history of hypersensitivity or allergic reactions to lidocaine or other amide-type local anesthetics. Cross-sensitivity between amide-type anesthetics can occur, and caution is advised when administering lidocaine to patients with a history of such allergies.

In conclusion, while lidocaine rectal suppositories can be an effective treatment for pain and discomfort in the rectal area, it is crucial to consider potential drug interactions that may affect its safety and effectiveness. Patients and prescribers are encouraged to review all current medications and health conditions before using lidocaine suppositories. If you have any questions or concerns about the use of this formulation or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.

Lidocaine HCl 120 mg Rectal Suppository is a solid dosage form designed to be inserted into the rectum, where it dissolves or melts at body temperature. Upon administration, the active ingredient, Lidocaine HCl, is released into the surrounding rectal tissues. Lidocaine is a local anesthetic that works by blocking the sodium channels in the cell membranes of nerve tissues. This action inhibits the initiation and conduction of nerve impulses, thereby providing a numbing effect and relief from pain in the localized area.

The rectal route of administration is particularly useful for patients who may have difficulty swallowing oral medications or for those who require a rapid onset of action. The rectal tissue has a rich blood supply, which allows for the medication to be absorbed quickly and effectively, providing both local and systemic effects. In the case of Lidocaine HCl, the primary effect is local anesthesia, which can be beneficial for treating conditions such as hemorrhoids, anal fissures, and other sources of rectal pain. The medication can also be used before diagnostic procedures or surgeries in the anorectal area to minimize discomfort.

For patients and prescribers considering the use of Lidocaine HCl 120 mg Rectal Suppository, it is important to understand that while the medication provides targeted relief, it should be used with caution in patients with certain medical conditions, such as heart block or severe heart failure. Additionally, the dosing frequency and duration of treatment should be carefully followed to avoid systemic toxicity, as excessive absorption of lidocaine can lead to adverse effects such as dizziness, tremors, or seizures. It is also crucial to ensure proper insertion technique to maximize the efficacy of the medication and minimize discomfort during administration.

As compounding pharmacists at Bayview Pharmacy, we are committed to providing high-quality, customized medications to meet the unique needs of our patients. If you have any questions about the Lidocaine HCl 120 mg Rectal Suppository or its use in treating specific disease states, please do not hesitate to reach out to us. We are here to support both patients and prescribers with the information and guidance necessary to ensure safe and effective treatment outcomes.

The lidocaine HCl 120 mg rectal suppository, while primarily intended for rectal administration to manage pain and discomfort associated with hemorrhoids, anorectal procedures, or inflammation, has been observed to have other potential applications as well. In some instances, and under the guidance of a healthcare provider, this formulation might be used off-label to relieve pain from fissures, pruritis ani (anal itching), and other similar conditions affecting the anorectal area. The local anesthetic effect of lidocaine provides temporary relief by numbing the local area, which can be a relief for patients undergoing various forms of discomfort.

Moreover, due to the systemic absorption capabilities of the rectal mucosa, lidocaine suppositories could theoretically be used in situations where oral administration of lidocaine is not feasible, such as in patients with dysphagia, vomiting, or those who have recently undergone oral or stomach surgery. However, physicians must closely monitor systemic absorption in such cases to avoid potential systemic toxicity. It is essential to note that the use of lidocaine in any form should be contraindicated in patients with a known hypersensitivity to local anesthetics of the amide type or to other components of the suppository.

While lidocaine suppositories are not typically used for their anti-inflammatory properties, the relief from pain they provide can indirectly reduce inflammation by minimizing the cycle of pain and trauma to the affected area. Limiting movement and irritation in the region can allow for a more conducive environment for healing. It is important to remember that lidocaine is primarily an anesthetic and does not address the underlying cause of the pain or inflammation, which should be concurrently managed according to the prescriber's recommendations.

For any off-label use, or if there are questions concerning the use of lidocaine HCl rectal suppositories for other conditions, it is crucial for patients and prescribers to discuss potential risks and benefits. Prescribers should be familiar with the patient's medical history and concurrent medications to avoid potential drug interactions. If further information on the formulation and possible uses of lidocaine HCl 120 mg rectal suppository is required, or if there are specific patient-related inquiries, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is ready to provide guidance and expert advice tailored to individual patient needs.