The Ketoprofen 10%/Piroxicam 1% Transdermal Gel is a specialized medication designed for topical application to provide relief from pain and inflammation directly at the site of discomfort. This semisolid formulation is dispensed through a pump mechanism, which ensures that patients can apply a consistent and accurate dose of the medication with each use. The gel base allows for the active ingredients, ketoprofen and piroxicam, to be absorbed through the skin, offering a targeted approach to treatment that can reduce systemic side effects often associated with oral administration of nonsteroidal anti-inflammatory drugs (NSAIDs).

Ketoprofen is a potent NSAID that works by inhibiting the cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins, substances that mediate pain, inflammation, and fever. Piroxicam, also an NSAID, operates similarly but may have a longer duration of action. The combination of these two drugs in a transdermal gel form allows for synergistic effects, enhancing the anti-inflammatory and analgesic properties while potentially minimizing the risk of gastrointestinal issues that are common with systemic NSAIDs.

This formulation is particularly useful for patients suffering from localized musculoskeletal conditions such as arthritis, tendinitis, or bursitis. By applying the gel directly to the affected area, patients can experience relief from pain and swelling, improving their range of motion and overall quality of life. The transdermal delivery system is also beneficial for patients who may have difficulties with oral administration or those who wish to avoid the gastrointestinal side effects of systemic NSAIDs.

It is important for both patients and prescribers to understand that while this transdermal gel provides localized relief, it should be used with caution in patients with known hypersensitivity to NSAIDs, and it is not recommended for use on broken or damaged skin. Additionally, patients should be advised to avoid exposure of the treated area to sunlight or artificial UV light to prevent photosensitivity reactions. As with any medication, monitoring for adverse effects is essential, and patients should be instructed to report any unusual symptoms to their healthcare provider.

For prescribers considering this formulation for their patients, it is crucial to assess the patient's overall health status, including renal and hepatic function, as well as their medication history to avoid potential drug interactions. The pharmacists at Bayview Pharmacy are available to provide further information on the formulation, its proper use, and to answer any questions regarding compounding options and patient-specific concerns. If you have any questions or require additional information, please do not hesitate to reach out to us.

The combination of ketoprofen and piroxicam in a transdermal gel formulation is designed to provide anti-inflammatory and analgesic effects when applied topically. Both ketoprofen and piroxicam are nonsteroidal anti-inflammatory drugs (NSAIDs) that work by inhibiting the cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins, substances that mediate inflammation and pain. This transdermal gel is intended for the treatment of localized pain and inflammation, such as that associated with musculoskeletal disorders, arthritis, strains, and sprains.

When using this ketoprofen 10%/piroxicam 1% transdermal gel, it is important to consider potential drug interactions. Both active ingredients, being NSAIDs, may interact with other medications that the patient is taking. Concurrent use of other NSAIDs, including over-the-counter products like ibuprofen or naproxen, should be avoided as this may increase the risk of gastrointestinal bleeding, ulceration, and renal impairment due to additive effects. Patients should also be cautious when combining this gel with anticoagulants (such as warfarin) or antiplatelet agents (like aspirin), as there may be an increased risk of bleeding.

Patients taking selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) for depression or other conditions should be aware that combining these with NSAIDs may further increase the risk of gastrointestinal bleeding. Additionally, the use of corticosteroids with this gel may compound the risk of gastrointestinal side effects. Patients on corticosteroids should consult their healthcare provider before using this formulation.

Those with high blood pressure or heart failure should be cautious, as NSAIDs can lead to fluid retention and worsen these conditions. Patients taking antihypertensive medications, such as ACE inhibitors, angiotensin receptor blockers (ARBs), or diuretics, should be aware that NSAIDs may reduce the effectiveness of these drugs. Furthermore, concurrent use of NSAIDs with lithium or methotrexate can lead to increased levels of these drugs in the blood, potentially leading to toxicity.

It is also important to note that the application of the gel should not be combined with other topical preparations on the same area of skin without medical advice, as there may be interactions or altered absorption. Additionally, the use of occlusive dressings over the area where the gel has been applied can increase systemic absorption of the NSAIDs, potentially leading to increased side effects.

Patients with a history of allergic reactions to aspirin or other NSAIDs should not use this product, as there is a risk of cross-reactivity. Signs of an allergic reaction include hives, facial swelling, asthma (wheezing), and shock. If any of these symptoms occur, use of the product should be discontinued immediately and medical attention sought.

Before using this ketoprofen 10%/piroxicam 1% transdermal gel, patients should discuss their current medication list with their healthcare provider to assess for potential interactions. This is crucial for ensuring safe and effective use of the medication. If you have any questions or require further information regarding drug interactions with this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support.

The Ketoprofen 10%/Piroxicam 1% Transdermal Gel is a specially designed medication that combines the anti-inflammatory and analgesic properties of two nonsteroidal anti-inflammatory drugs (NSAIDs), ketoprofen and piroxicam. This transdermal formulation is designed to deliver the active ingredients directly to the site of pain and inflammation through the skin, providing localized relief without the systemic side effects often associated with oral NSAIDs.

Ketoprofen, as part of this formulation, works by inhibiting the cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are lipid compounds that play a key role in the inflammation process. By reducing their production, ketoprofen effectively decreases inflammation, pain, and swelling in the affected area. Piroxicam operates in a similar manner, also inhibiting the COX enzymes, but it is chemically distinct from ketoprofen, which may provide a synergistic effect when used in combination, potentially enhancing the overall anti-inflammatory and analgesic effects.

The gel is designed to be applied topically, which allows for a high concentration of the drugs to be delivered directly to the affected tissues. This targeted approach aims to minimize systemic absorption and reduce the risk of systemic side effects such as gastrointestinal irritation or cardiovascular risks that are often associated with oral NSAIDs. The transdermal delivery system also provides a more consistent release of medication over time, which can help in managing symptoms more effectively.

The semisolid formulation is dispensed through a pump mechanism, which ensures that a precise amount of medication is applied with each use. This dosing accuracy is important for maintaining the effectiveness of the treatment while minimizing the risk of overuse or side effects. The gel-like consistency of the formulation allows for easy application and quick absorption into the skin, providing convenience and comfort for the patient.

This transdermal gel is commonly used to treat localized musculoskeletal pain, such as that associated with osteoarthritis, rheumatoid arthritis, sprains, strains, and other soft tissue injuries. By applying the gel to the skin over the affected area, patients can experience relief from pain and reduction in swelling, which can improve mobility and quality of life.

It is important for both patients and prescribers to understand that while this formulation provides targeted relief, it should be used with caution in patients with known hypersensitivity to NSAIDs, and it is not recommended for use on broken or damaged skin. Additionally, patients should be advised to avoid exposing the treated area to sunlight or artificial UV rays, as this can increase the risk of photosensitivity reactions.

If you have any questions or require further information about the Ketoprofen 10%/Piroxicam 1% Transdermal Gel, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this medication.

The compounding pharmacists at Bayview Pharmacy have prepared a unique Ketoprofen 10%/Piroxicam 1% Transdermal Gel, which is designed to deliver anti-inflammatory and analgesic effects directly to the site of musculoskeletal pain such as that caused by osteoarthritis, rheumatoid arthritis, tendonitis, bursitis, and other localized inflammatory conditions. Although this gel is primarily intended to manage those conditions, it might possess other clinical utilities due to the properties of its active ingredients.

Aside from its primary indications, the transdermal gel may also be employed for the symptomatic relief of soft tissue injuries, such as sprains and strains. The topical route of delivery minimizes systemic side effects compared to oral administration, making it a potentially beneficial choice for patients who are at increased risk of gastrointestinal, renal, or cardiovascular complications commonly associated with systemic NSAIDs. Moreover, this mode of application may facilitate the use in treating localized sports injuries where localized anti-inflammatory action is desirable.

Some patients with other chronic pain conditions, such as neuropathic pain or certain types of localized chronic pain syndromes, may experience benefit from the anti-inflammatory effects of the ketoprofen and piroxicam combination. Each case should be evaluated individually, considering the patient's medical history, concurrent medications, and the presence of any contraindications to the use of NSAIDs. As with any medication, it is essential to use this gel as directed by a healthcare professional.

While the focus of this formulation is on the delivery of active ingredients through the skin directly to the affected area, caregivers should be cautious about potential side effects, including local skin reactions. Continuous monitoring and follow-up with patients are advised to ensure efficacy and safety. It is also vital for patients to be aware that this gel is for topical use only and should not be used with occlusive dressings unless advised by a healthcare professional.

Overall, this compounded formulation made at Bayview Pharmacy provides a tailored alternative for patients needing targeted pain relief with reduced systemic exposure. Its innovative delivery through a pump mechanism ensures controlled, clean, and easy application. Patients and prescribers seeking alternative applications or more information about this compound are encouraged to reach out to us, the knowledgeable team of compounding pharmacists at Bayview Pharmacy, for personalized guidance and support.