Our compounded Ketamine 5%/Ketoprofen 10%/Lidocaine HCl 5% Topical Gel is a specialized medication designed for targeted pain relief. This unique formulation combines the analgesic and anesthetic properties of three active ingredients to provide a synergistic effect for managing pain. Ketamine, a medication primarily used for starting and maintaining anesthesia, has been found to have analgesic properties when used in lower, sub-anesthetic doses. In this topical formulation, it may help in reducing the sensation of pain by blocking NMDA receptors, which are involved in pain transmission.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), works by inhibiting the enzyme cyclooxygenase, which is involved in the production of prostaglandins, substances that mediate inflammation and pain. By reducing the levels of prostaglandins, ketoprofen can help alleviate inflammation and associated pain. Lidocaine HCl, a local anesthetic, provides immediate relief by blocking sodium channels and thus the transmission of pain signals along the nerves.

The combination of these three agents in a 5%/10%/5% concentration, respectively, in a gel base allows for direct application to the affected area, offering localized relief without the systemic side effects often associated with oral medications. The semisolid formulation is designed to be dispensed through a pump mechanism, which ensures easy and precise dosing. The gel consistency allows for quick absorption through the skin and can be particularly beneficial for patients who have difficulty swallowing pills or who prefer a non-invasive treatment option.

This topical gel is commonly used for the treatment of localized musculoskeletal pain, neuropathic pain, and inflammatory conditions. It may be particularly useful for patients suffering from conditions such as arthritis, tendonitis, bursitis, or nerve-related pain such as postherpetic neuralgia. The combination of anesthetic and anti-inflammatory effects can provide significant pain relief and improve the quality of life for patients dealing with chronic pain conditions.

As with any compounded medication, it is important for patients and prescribers to be aware of the potential for side effects and interactions with other medications. The pharmacists at Bayview Pharmacy are available to discuss the benefits and considerations of this topical gel formulation, ensuring that it is appropriate for the patient's specific condition and medical history. We encourage open communication and are here to answer any questions or concerns regarding this or any other compounded medication. Please reach out to us for personalized support and guidance.

The topical gel formulation containing Ketamine 5%, Ketoprofen 10%, and Lidocaine HCl 5% is designed for localized application and is intended to provide analgesia and reduce inflammation in the area of application. However, it is important to consider potential drug interactions when using this compound, especially if the patient is taking other medications systemically or applying other topical agents.

Ketamine, when used topically, is generally considered to have a low risk of systemic absorption and thus a low risk of systemic drug interactions. However, caution should be exercised if the patient is taking CNS depressants or psychoactive drugs, as there may be an additive effect on sedation and CNS depression. Additionally, if the patient is prescribed other NMDA antagonists, the risk of CNS side effects may be increased.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can interact with other NSAIDs, increasing the risk of gastrointestinal ulceration or bleeding. Although the systemic absorption of ketoprofen from topical application is lower than from oral administration, it is still important to consider the total NSAID load, especially in patients taking oral NSAIDs or anticoagulants. Concomitant use with other medications that affect renal function, such as ACE inhibitors or diuretics, may also require monitoring.

Lidocaine is a local anesthetic and, when applied topically, has a low risk of systemic absorption. However, if used concomitantly with other local anesthetics or medications that affect cardiac conduction, there may be an increased risk of adverse cardiac effects. Caution is advised if the patient is on antiarrhythmic drugs, as there may be additive effects on the heart.

It is also important to consider the potential for skin irritation or allergic reactions when using this compound, especially if the patient has a history of sensitivity to any of the ingredients or similar medications. The use of other topical preparations on the same area of skin should be discussed with a healthcare provider to avoid potential interactions or enhanced absorption through compromised skin integrity.

This compounded formulation is used to treat localized pain, inflammation, and neuropathic conditions. The combination of an NMDA antagonist (ketamine), an NSAID (ketoprofen), and a local anesthetic (lidocaine) provides a multimodal approach to pain management, which can be beneficial in conditions such as arthritis, tendonitis, neuropathic pain, and other musculoskeletal disorders. The precise application through a pump mechanism allows for consistent dosing and targeted therapy, minimizing systemic exposure and potential side effects.

If you have any questions or require further information regarding the use of this compounded formulation or potential drug interactions, please reach out to us at Bayview Pharmacy. We are here to ensure the safe and effective use of this medication for your patients.

The Ketamine 5%/Ketoprofen 10%/Lidocaine HCl 5% Topical Gel is a compounded medication designed to deliver a combination of active ingredients directly to the site of pain or inflammation through the skin. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application. The gel-like consistency ensures that the medication stays where it is applied and facilitates the absorption of the active ingredients into the affected area.

Ketamine, a medication primarily used for starting and maintaining anesthesia, has been found to have analgesic properties when used in lower, sub-anesthetic doses. In this topical formulation, ketamine works by blocking N-methyl-D-aspartate (NMDA) receptors in the nervous system, which are involved in the transmission of pain signals. By inhibiting these receptors, ketamine can help reduce the sensation of pain.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins. Prostaglandins are chemicals in the body that promote inflammation, pain, and fever. By reducing their production, ketoprofen effectively decreases inflammation and pain in the tissues where the gel is applied.

Lidocaine HCl is a local anesthetic that provides rapid numbing effects to the area of application. It works by blocking sodium channels on the neuronal cell membrane, which prevents the initiation and conduction of nerve impulses. This action results in a temporary loss of sensation in the area, providing relief from pain.

When combined, these three ingredients offer a multimodal approach to pain management. The gel is particularly useful for conditions that involve inflammation and pain, such as musculoskeletal injuries, neuropathic pain, and certain types of arthritis. By applying the gel topically, patients can achieve localized relief with potentially fewer systemic side effects compared to oral medications.

It is important for both patients and prescribers to understand that while this topical gel can provide significant relief, it should be used as directed by a healthcare professional. The compounding pharmacists at Bayview Pharmacy can provide guidance on the appropriate use of this medication, including the amount to apply and the frequency of application. If you have any questions or require further information about this formulation and its use in treating specific disease states, please reach out to us.

While the primary use of the combination formula containing Ketamine 5%, Ketoprofen 10%, and Lidocaine HCl 5% Topical Gel is for the management of pain, particularly in patients with neuropathic pain, complex regional pain syndrome (CRPS), and musculoskeletal pain, this topical preparation may also have a broader therapeutic potential in other clinical scenarios. Due to the individual properties of each component, the gel may serve as an adjunctive therapy for those suffering from inflammatory skin conditions that have an associated pain component, such as psoriasis or certain types of dermatitis. The anti-inflammatory properties of ketoprofen could help alleviate the local inflammation, while lidocaine and ketamine work synergistically to provide analgesic effects.

In addition, patients experiencing post-herpetic neuralgia or other neuropathic conditions resulting from nerve injury could potentially find some relief with the local application of this gel. Another possible off-label use of the formula could be for pain associated with osteoarthritis in superficial joints, like the hands or knees, where the active ingredients may penetrate to exert their effects. However, it's important to consider the depth of the affected tissue and the potential for systemic absorption, especially with chronic use.

Due to the presence of ketamine, a controlled substance known for its dissociative anesthetic properties, this gel should be used with caution, specifically under the supervision of a physician familiar with its systemic effects, and it is generally reserved for cases that are refractory to standard treatments. The prescribing physician should monitor the patient for any potential adverse effects related to all three ingredients, such as skin irritation or systemic absorption. It should also be noted that this formulation, due to its contents and potential for abuse, may not be the first line of therapy for any condition.

This compounded topical gel may serve as a valuable option for patients who have contraindications, intolerance, or who have failed to respond to oral pain medications. Compounded formulas such as this one enable the delivery of multiple drugs at the site of pain, potentially reducing systemic side effects and interactions. Nevertheless, due to the complex nature of the gel, the decision to use this formulation should be made on a case-by-case basis after a thorough evaluation of the patient's individual medical history, current medications, and overall health status.

Given the potential for off-label applications, it is paramount for both patients and prescribers to communicate regularly and assess the efficacy and safety of the treatment. If you have any questions about this formulation, or its potential uses, please do not hesitate to reach out to us at Bayview Pharmacy. We are committed to providing comprehensive information and support to ensure optimal care and outcomes for our patients.