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Hydroxychloroquine Sulfate 25 mg/ml Oral Liquid

FDA-approved generic
Dose form
Oral Liquid
Active ingredients
Hydroxychloroquine Sulfate
For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
Starting at
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Requires a prescription from your own provider. Bayview is a pharmacy and does not prescribe.
Ships within 1 to 2 business days after pharmacist verification
HSA and FSA eligible
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Get a one-page sheet with everything your doctor needs to prescribe this and send it to Bayview.

Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Hydroxychloroquine Sulfate
Oral Liquid
65adb126c8e1173016c0f153
Service area

Can we ship this formula to your state?

Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Available in

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Our current service area

Currently licensed Limited basis, registration pending Not available for this formula Not currently licensed

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Prepared to a prescriber's order for one patient. Not FDA-approved.

This formulation

This is a compounded oral liquid containing hydroxychloroquine sulfate, prepared to a prescriber's order for one patient. Compounded preparations are not FDA-approved.

FDA product listings

These listings cover every salt or ester form of each drug in the FDA National Drug Code Directory.

FDA-approved products containing hydroxychloroquine are listed in tablet form. No hydroxychloroquine product of any kind is listed in liquid form.

Storage category and dating

Liquid bases can be aqueous or nonaqueous, and USP <795> classifies the preparation by its water activity. Aqueous preparations carry shorter default beyond-use dates than nonaqueous ones. The date printed on the label is the one to follow.

Sources

Hydroxychloroquine is an antimalarial and antirheumatic medicine that a pharmacy may compound when a prescriber orders it.

About this ingredient

Hydroxychloroquine is a 4-aminoquinoline, a hydroxylated relative of chloroquine with both antimalarial and anti-inflammatory activity. How it calms autoimmune disease is not fully known. Manufactured products are tablets, including Plaquenil (hydroxychloroquine sulfate), Sovuna and generics from several companies. The Plaquenil label indicates it for treatment of uncomplicated malaria and for malaria prophylaxis where chloroquine resistance is not reported, in adults and children, and for rheumatoid arthritis, systemic lupus erythematosus and chronic discoid lupus erythematosus in adults. A prescriber might order it compounded as an oral liquid for someone who cannot swallow tablets, or in a strength that is not manufactured. Compounded preparations are not FDA-approved and require a prescription.

Safety and interactions

Plaquenil has no boxed warning, but its label lists serious risks: cardiomyopathy and QT prolongation with ventricular arrhythmias, irreversible retinal damage linked to cumulative dose and duration, severe skin reactions such as Stevens-Johnson syndrome and DRESS, worsening of psoriasis and porphyria, low blood counts, hemolysis in G6PD deficiency, muscle and nerve damage, suicidal thoughts and other psychiatric effects, and severe low blood sugar. Do not take it if you are allergic to 4-aminoquinoline drugs. It is not recommended with other drugs that prolong the QT interval, it can raise digoxin and cyclosporine levels, and MedlinePlus advises taking antacids 4 hours apart from it. The label reports no identified drug-associated risk of major birth defects, and LactMed notes international guidelines consider it acceptable during breastfeeding. Keep up with eye exams, and talk to your prescriber or pharmacist about any vision change, fainting or mood change.

Hydroxychloroquine is a 4-aminoquinoline antimalarial; its anti-inflammatory and immunomodulatory mechanism in rheumatoid arthritis and lupus is not fully known. Mean absolute oral bioavailability is 79 percent fasting, about 50 percent is bound to plasma proteins, and it distributes extensively to tissues. It is metabolized mainly by CYP2C8, CYP3A4 and CYP2D6, with desethylhydroxychloroquine the major metabolite, and terminal half-life in whole blood is 40 to 50 days with chronic dosing. Labeled indications for Plaquenil (Advanz Pharma) are uncomplicated malaria, malaria prophylaxis in areas without chloroquine resistance, and adult rheumatoid arthritis, systemic lupus and chronic discoid lupus. MedlinePlus notes use for porphyria cutanea tarda; this is not an FDA-approved indication, and the label warns of hepatotoxicity in patients with PCT. The label recommends a baseline retinal exam within the first year, annual BCVA, visual field and SD-OCT testing for higher-risk patients, and deferral of annual screening until five years of use in those without risk factors. Correct hypokalemia and hypomagnesemia, and monitor cardiac function, blood counts, glucose, muscle strength and reflexes during long-term therapy. Dosing is per prescriber. Hydroxychloroquine is not a controlled substance.

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Using and storing

How it is used

Shake the bottle if your label says to. Measure each dose with the oral syringe or dosing cup the pharmacy gave you, never a kitchen spoon. Give the liquid slowly into the mouth. Rinse the syringe with water after each use. Call the pharmacy if you are unsure how to measure.

Storing it

Storage depends on the vehicle. Water-based liquids with a preservative usually carry a USP <795> beyond-use date of up to 35 days; without a preservative they are kept refrigerated for up to 14 days. Oil-based (nonaqueous) oral liquids may carry up to 90 days. Your label states whether to refrigerate and the beyond-use date. Keep out of reach of children and discard after that date.

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Prescribing and ordering FAQs

Formula Information

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Drug Interactions

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Frequently Asked Questions

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About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Hydroxychloroquine Sulfate 25 mg/ml Oral Liquid
Oral Liquid
controlled

Take orally

Once daily