The Hydrocortisone 130 mg/Lidocaine HCl 195 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum, where it dissolves or melts to release its active ingredients for local or systemic absorption. This particular formulation combines the anti-inflammatory properties of hydrocortisone with the local anesthetic effects of lidocaine hydrochloride to provide symptomatic relief from various conditions affecting the anorectal area.

Hydrocortisone is a corticosteroid that works by reducing inflammation, itching, and swelling. It is commonly used in the treatment of hemorrhoids, anal fissures, and other inflammatory conditions of the anorectal region. By decreasing inflammation, hydrocortisone can alleviate pain and discomfort, allowing for easier bowel movements and healing of affected tissues.

Lidocaine HCl is a local anesthetic that provides rapid pain relief by blocking nerve signals in the body. When included in a rectal suppository, lidocaine helps to numb the anorectal area, offering immediate relief from pain, itching, and discomfort. This can be particularly beneficial for patients experiencing severe pain during defecation or those with painful anorectal disorders.

The combination of hydrocortisone and lidocaine in a single suppository allows for the simultaneous management of inflammation and pain. This dual-action approach can improve patient comfort and adherence to treatment, potentially leading to faster healing and resolution of symptoms. The rectal route of administration ensures that the medication is delivered directly to the site of inflammation, maximizing local effects while minimizing systemic absorption and potential side effects.

Patients and prescribers should be aware that while this formulation provides targeted relief, it is important to follow the recommended dosing and administration guidelines to avoid potential complications such as local irritation or systemic side effects. Additionally, this medication should be used as part of a comprehensive treatment plan that may include dietary changes, increased fiber intake, and other supportive measures to manage anorectal conditions effectively.

For those considering the use of Hydrocortisone 130 mg/Lidocaine HCl 195 mg Rectal Suppository, it is essential to consult with a healthcare professional to ensure it is appropriate for the individual's specific condition and to receive guidance on proper use. If you have any questions or require further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing expert advice and support to both patients and prescribers.

The hydrocortisone and lidocaine HCl rectal suppository is a combination medication used for its anti-inflammatory and anesthetic properties, respectively. Hydrocortisone is a corticosteroid that helps to reduce swelling, itching, and discomfort, while lidocaine is a local anesthetic that provides temporary relief from pain by numbing the affected area. This formulation is typically used to treat conditions such as hemorrhoids, anal fissures, and other rectal or anal discomforts.

When considering drug interactions, it is important to note that hydrocortisone, being a corticosteroid, can interact with a variety of medications. It may reduce the effectiveness of live or live-attenuated vaccines due to its immunosuppressive effects. Patients should consult with their healthcare provider before receiving any vaccinations. Additionally, hydrocortisone can interact with drugs that induce or inhibit hepatic enzymes, particularly CYP3A4, which can affect the metabolism and clearance of hydrocortisone, potentially leading to altered effects or side effects.

Lidocaine, on the other hand, is metabolized by the liver and should be used with caution in patients taking other medications that can affect liver function. Drugs that inhibit the metabolism of lidocaine, such as beta-blockers or cimetidine, may increase the risk of lidocaine toxicity. Conversely, medications that induce liver enzymes may reduce the efficacy of lidocaine.

Both hydrocortisone and lidocaine may have additive effects with other medications that suppress the immune system or affect cardiac conduction, respectively. For example, combining hydrocortisone with other corticosteroids or immunosuppressants can increase the risk of immunosuppression. Lidocaine should be used with caution in patients taking antiarrhythmic drugs or other medications that affect cardiac conduction, as there is a potential for additive cardiac effects.

It is also important to consider the potential for systemic absorption of both hydrocortisone and lidocaine when administered rectally, although this is generally low. If systemic absorption occurs, the potential for systemic drug interactions increases. Patients should inform their healthcare provider of all medications they are taking, including prescription drugs, over-the-counter medications, and herbal supplements, to assess for potential interactions.

Patients with pre-existing conditions such as liver disease, heart conditions, or those who are immunocompromised should use this medication with caution and under the guidance of a healthcare provider. Additionally, long-term or excessive use of corticosteroids, including hydrocortisone, can lead to systemic side effects such as adrenal suppression, so it is important to follow the prescribed duration and dosage.

If you have any questions or concerns regarding the use of this formulation or potential drug interactions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to safely and effectively manage your condition.

The Hydrocortisone 130 mg/Lidocaine HCl 195 mg Rectal Suppository is a solid dosage form designed to be inserted into the rectum, where it dissolves or melts at body temperature. Upon administration, the suppository base, typically made from substances like cocoa butter or a synthetic substitute, begins to melt or dissolve, allowing the active pharmaceutical ingredients, hydrocortisone and lidocaine, to be released and absorbed through the rectal mucosa.

Hydrocortisone is a corticosteroid that works by reducing inflammation, itching, and swelling. It does this by inhibiting the release of substances in the body that cause inflammation. This makes it particularly effective in treating inflammatory conditions of the anorectal area, such as hemorrhoids, anal fissures, and proctitis. By exerting its anti-inflammatory action locally, hydrocortisone can provide symptomatic relief from pain, itching, and discomfort.

Lidocaine HCl is a local anesthetic that provides rapid pain relief by blocking the transmission of nerve signals in the body. When applied to the rectal area, lidocaine can numb the region, offering immediate relief from pain and discomfort associated with conditions like hemorrhoids and other anorectal disorders. The combination of hydrocortisone and lidocaine in a single suppository allows for both the reduction of inflammation and the management of pain, making it a comprehensive treatment option for patients suffering from these conditions.

This formulation is specifically designed for rectal administration to ensure that the active ingredients are delivered directly to the affected area, providing targeted relief with minimal systemic absorption. This localized approach helps to maximize therapeutic effects while reducing the potential for systemic side effects that can occur with oral medications. The use of suppositories is particularly beneficial for patients who may have difficulty swallowing pills or for those who require medication to act directly on the rectal area.

It is important for both patients and prescribers to understand that while this formulation provides relief from symptoms, it is not a cure for the underlying conditions. Patients should follow the dosing instructions provided by their healthcare provider and report any persistent or worsening symptoms. Additionally, long-term use of corticosteroids, even locally, should be monitored due to potential systemic effects.

If you have any questions about the Hydrocortisone 130 mg/Lidocaine HCl 195 mg Rectal Suppository or its use in treating anorectal disorders, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to effectively manage these conditions.

The hydrocortisone and lidocaine rectal suppository formulation is primarily indicated for the management of hemorrhoidal pain, inflammation, itching, and discomfort. However, the formulation can also be considered for other uses where both the anti-inflammatory action of hydrocortisone and the anesthetic effect of lidocaine might be beneficial. These potential other uses include the treatment of anal fissures, which are small tears in the lining of the anus that can be extremely painful, and proctitis, which is inflammation of the rectum lining. Furthermore, it may be helpful in the management of pain following anorectal surgery or procedures.

In some instances, clinicians may recommend this formulation for off-label purposes, such as to alleviate discomfort associated with chronic conditions that result in ongoing rectal or perianal pain, even if not specifically associated with hemorrhoidal issues. For example, patients with inflammatory bowel diseases such as Crohn’s disease or ulcerative colitis may find temporary relief from acute flares that affect the rectal area. However, the chronic use of corticosteroids, even topically, should be approached with caution due to potential systemic absorption and the risk of corticosteroid-related side effects, particularly with prolonged use.

This suppository formulation can not only provide local effects but may also offer some systemic absorption, especially with the lidocaine component. Hence, while beneficial for pain relief, it is crucial for patients to be aware of the potential for systemic lidocaine absorption, which could be contraindicated in certain conditions such as severe heart block or in patients taking certain antiarrhythmic drugs. Patients should always be advised that every medication, including topical agents, carries the possibility of systemic exposure and the risk of side effects or interactions with other medications they may be taking.

Patient education regarding the proper administration of rectal suppositories is essential, as is understanding that while application may provide symptom relief, it does not cure the underlying cause of the pain or inflammation. As such, patients should also be encouraged to follow-up with their prescribing physician for ongoing management, particularly if symptoms persist or worsen.

It's important to note that use of any medication carries the risk of adverse reactions or interactions with other medications, which is why patients should consult closely with their healthcare provider to ensure that this particular combination of hydrocortisone and lidocaine is appropriate for their condition. If you have any questions or require more information on the possible uses of this suppository formulation or to discuss patient-specific issues, please do not hesitate to reach out to us at Bayview Pharmacy.