Guanfacine 0.1 mg/mL Oral Suspension is a compounded liquid formulation of guanfacine, a selective alpha-2A adrenergic receptor agonist. This medication is commonly used in the management of attention deficit hyperactivity disorder (ADHD) in pediatric patients and adolescents. It may also be prescribed for the treatment of hypertension. The oral suspension provides a homogeneous mixture, ensuring uniform dispersion of the active ingredient for consistent dosing with each administration.

The therapeutic effects of guanfacine in ADHD are achieved through its action on the prefrontal cortex of the brain. By stimulating alpha-2A adrenergic receptors, guanfacine enhances prefrontal cortical regulation of attention and behavior, leading to improvements in attention span, impulse control, and hyperactivity levels. In the context of hypertension, guanfacine decreases sympathetic nerve impulses from the vasomotor center to the heart and blood vessels, resulting in vasodilation and a reduction in blood pressure.

This compounded oral suspension is particularly beneficial for patients who have difficulty swallowing tablets or require precise dose adjustments that are not available in commercially manufactured products. The liquid form allows for individualized dosing, which is essential for achieving optimal therapeutic outcomes, especially in pediatric populations where dosing often needs to be tailored based on weight and response.

Patients and caregivers should administer the suspension exactly as prescribed by the healthcare provider. It is important to shake the bottle well before each use to ensure the medication is evenly distributed. A calibrated measuring device, such as an oral syringe or dosing cup, should be used to measure each dose accurately. Do not use household spoons, as they may not provide the correct dosage.

Potential side effects of guanfacine may include drowsiness, fatigue, dizziness, headache, dry mouth, abdominal pain, hypotension (low blood pressure), and bradycardia (slow heart rate). Patients should be cautioned about performing activities that require mental alertness, such as driving or operating heavy machinery, until they understand how guanfacine affects them. It is advisable to avoid abrupt discontinuation of the medication, as this may lead

Guanfacine 0.1 mg/mL Oral Suspension is a liquid dosage form in which guanfacine, an alpha-2 adrenergic agonist, is dispersed uniformly throughout a liquid medium, providing a homogeneous mixture for administration. This formulation is primarily used in the management of attention deficit hyperactivity disorder (ADHD) and hypertension. As with any medication, it is important to be aware of potential drug interactions that may affect the efficacy and safety of guanfacine.

Guanfacine is metabolized primarily by the cytochrome P450 3A4 (CYP3A4) enzyme. Therefore, drugs that inhibit or induce CYP3A4 can significantly alter the plasma concentration of guanfacine. Strong CYP3A4 inhibitors, such as ketoconazole, itraconazole, and clarithromycin, can increase guanfacine levels, potentially leading to enhanced pharmacological effects and an increased risk of adverse reactions such as hypotension, bradycardia, and sedation. Conversely, CYP3A4 inducers like rifampin, phenytoin, and carbamazepine may decrease guanfacine levels, reducing its therapeutic efficacy.

Concomitant use of guanfacine with other central nervous system (CNS) depressants, including alcohol, benzodiazepines, and opioids, can potentiate the sedative effects of guanfacine. Patients should be advised to avoid or limit the use of such substances while taking guanfacine to prevent excessive sedation and impairment of cognitive and motor functions.

Antihypertensive agents, when used in combination with guanfacine, may have an additive effect on lowering blood pressure. This can increase the risk of hypotension and related symptoms such as dizziness, lightheadedness, and fainting. Patients should be monitored closely, and dose adjustments may be necessary to maintain optimal blood pressure control without adverse effects.

Guanfacine may also interact with medications that affect heart rate. Caution is advised when guanfacine is used with other drugs that can cause bradycardia, such as beta-blockers and certain calcium channel blockers, as this may lead to an increased risk of significant bradycardia.

Patients and prescribers should be aware of these potential interactions and monitor for any signs of adverse effects or changes in therapeutic efficacy. It is crucial to inform healthcare providers of all medications, including over-the-counter drugs and supplements, that the patient is taking to ensure safe and effective use of guanfacine oral suspension. If you have any questions or concerns regarding drug interactions with guanfacine, please reach out to us at Bayview Pharmacy for further assistance.

Guanfacine 0.1 mg/mL Oral Suspension is a liquid dosage form designed to deliver the active ingredient, guanfacine, in a uniform and consistent manner. This formulation ensures that each dose contains an exact concentration of guanfacine, dispersed evenly throughout the liquid medium. This homogeneity is crucial for maintaining the therapeutic efficacy and safety of the medication, as it allows for precise dosing tailored to the individual needs of each patient.

Guanfacine is an alpha-2 adrenergic agonist that primarily works by stimulating receptors in the brain, which leads to a reduction in sympathetic nerve impulses. This action results in decreased heart rate and blood pressure, making guanfacine effective in managing conditions such as hypertension. Additionally, guanfacine is commonly used in the treatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents. In this context, it is believed to improve symptoms by enhancing prefrontal cortex function, which is responsible for attention, impulse control, and executive functioning.

The oral suspension form of guanfacine is particularly beneficial for patients who may have difficulty swallowing tablets or require flexible dosing adjustments. The liquid form allows for easy administration and can be measured accurately using a dosing syringe or cup, ensuring that patients receive the correct amount of medication. This is especially important in pediatric populations, where dosing often needs to be adjusted based on weight and response to treatment.

For prescribers, the guanfacine oral suspension offers a versatile option for titrating doses to achieve optimal therapeutic outcomes while minimizing potential side effects. The ability to adjust doses incrementally can help in finding the most effective dose with the least adverse effects, which is crucial in managing chronic conditions like ADHD and hypertension. Additionally, the liquid formulation can be an excellent alternative for patients with swallowing difficulties or those who prefer liquid medications over tablets.

Patients and caregivers should be informed about the importance of shaking the bottle well before each use to ensure the medication is properly mixed. It is also essential to use the provided measuring device to ensure accurate dosing. Consistent administration at the same time each day can help maintain stable blood levels of the medication, contributing to its effectiveness.

If you have any questions about guanfacine 0.1 mg/mL Oral Suspension or its use in treating specific conditions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to ensure the best possible outcomes for your patients.

Guanfacine 0.1 mg/mL Oral Suspension is primarily used for the management of attention deficit hyperactivity disorder (ADHD) and hypertension. However, this formulation may have other potential uses that are not as widely recognized but could be beneficial in certain clinical scenarios. One such use is in the management of anxiety disorders. Guanfacine, as an alpha-2 adrenergic agonist, can help modulate the sympathetic nervous system, potentially reducing symptoms of anxiety by promoting a calming effect. This can be particularly useful in patients who experience anxiety as a comorbid condition with ADHD or hypertension, providing a dual benefit from a single medication.

Additionally, guanfacine may be considered for off-label use in the treatment of tic disorders, such as Tourette syndrome. The calming effect on the central nervous system can help reduce the frequency and severity of tics, offering an alternative to traditional antipsychotic medications, which may have more significant side effects. Furthermore, guanfacine's role in improving executive functioning and working memory could be explored in patients with cognitive impairments or developmental disorders, where these cognitive domains are affected.

For prescribers, it is important to consider the pharmacokinetic properties of the oral suspension form, which allows for precise dosing adjustments and may be particularly advantageous in pediatric or geriatric populations where swallowing tablets may be challenging. The liquid formulation ensures uniform distribution of the active ingredient, providing consistent therapeutic effects. Patients and caregivers should be informed about the potential benefits and risks associated with off-label uses, and any decision to use guanfacine for these purposes should be made collaboratively, taking into account the individual patient's health profile and treatment goals.

As with any medication, monitoring for side effects such as sedation, hypotension, or bradycardia is essential, especially when used for non-traditional indications. Patients should be advised to report any adverse effects or concerns to their healthcare provider promptly. If you have any questions or need further information about the use of Guanfacine 0.1 mg/mL Oral Suspension for these or other conditions, please reach out to us at Bayview Pharmacy. We are here to support both patients and healthcare providers in optimizing therapeutic outcomes.