This compounded topical ointment combines Erythromycin at a concentration of 10 mg/g and Neomycin Sulfate at 3.5 mg/g, formulated in a semi-solid base designed for external application to the skin. The ointment is dispensed in a tube and provides a greasy or oily medium that facilitates the delivery of the active antibiotics directly to the affected area, promoting localized treatment of skin conditions.

Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, effectively stopping the growth of sensitive bacteria. Neomycin Sulfate is an aminoglycoside antibiotic that interferes with bacterial protein synthesis by binding to the 30S ribosomal subunit, leading to the misreading of the genetic code and resulting in bacterial cell death. The combination of these two antibiotics offers a broad-spectrum antibacterial effect against a wide range of Gram-positive and some Gram-negative organisms.

This ointment is primarily used for the topical treatment of bacterial skin infections. By applying it directly to the site of infection, high concentrations of the antibiotics are delivered where they are needed most, reducing systemic absorption and minimizing the risk of systemic side effects. The ointment base not only facilitates prolonged contact of the medication with the skin but also helps in moisturizing and protecting the affected area, which can aid in the healing process.

Patients should apply a thin layer of the ointment to the affected area as directed by their healthcare provider, usually one to three times daily. Before application, the area should be cleaned and dried thoroughly. It is important to wash hands before and after applying the ointment to prevent the spread of infection. The duration of treatment depends on the severity of the infection and the patient's response to therapy; therefore, adherence to the prescribed regimen is crucial for optimal outcomes.

Possible side effects may include local reactions such as redness, itching, irritation, or swelling at the site of application. While rare, allergic reactions to either erythromycin or neomycin sulfate can occur, manifesting as rash, hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. If patients experience any severe or persistent adverse effects, they should discontinue use and consult their healthcare provider promptly.

Precautions should be taken in patients with known hypersensitivity to erythromycin, neomycin, or other macrolide or aminoglycoside antibiotics. The ointment should not be used on large areas of damaged skin or in conditions where significant systemic absorption of the antibiotics may occur, due to the risk of ototoxicity associated with neomycin. Use with caution in patients with renal impairment, as neomycin can accumulate in the body when renal function is compromised.

For prescribers, it is important to consider the patient's medical history, potential allergies, and current medications to avoid contraindications and interactions. Monitoring for signs of superinfection with non-susceptible organisms, including fungi, is recommended during prolonged use. Educating patients on the proper use of the ointment and the importance of completing the full course of therapy, even if symptoms improve, can enhance treatment efficacy and reduce the risk of resistance.

This compounded formulation offers a tailored approach to treating bacterial skin infections, combining the benefits of two antibiotics to enhance antibacterial coverage. By leveraging the expertise in compounding, individualized therapies can be provided to meet specific patient needs that are not addressed by commercially available products.

If you have any questions or require further information about this formulation, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist both patients and healthcare providers.

This Erythromycin 10 mg/g/Neomycin Sulfate 3.5 mg/g topical ointment is a combination antibiotic formulation designed for external application to the skin. It is primarily used to treat localized skin infections, inflammation, and to aid in wound healing. Erythromycin, a macrolide antibiotic, works by inhibiting bacterial protein synthesis, thereby stopping bacterial growth. Neomycin sulfate, an aminoglycoside antibiotic, disrupts bacterial cell wall synthesis, leading to bacterial cell death. Together, these antibiotics provide a broad spectrum of antibacterial activity against a variety of gram-positive and gram-negative bacteria.

When considering drug interactions, it is important to note that this formulation is intended for topical use and systemic absorption is generally minimal. However, interactions can still occur, particularly if the ointment is applied over large areas of the body, on broken skin, or if used for prolonged periods. Patients and prescribers should be aware of potential interactions with other topical or systemic medications.

Concomitant use of other topical medications on the same area of skin may alter the absorption and effectiveness of this ointment. For instance, the use of other topical antibiotics or corticosteroids may increase the risk of skin irritation or allergic reactions. Patients should inform their healthcare provider of all topical products they are using to avoid potential interactions.

Systemic absorption of erythromycin can potentially interact with other medications metabolized by the cytochrome P450 enzyme system, particularly CYP3A4. Although systemic absorption from topical application is low, caution is advised when using this ointment in conjunction with drugs such as warfarin, theophylline, or statins, as erythromycin can increase their plasma concentrations, leading to enhanced effects or toxicity.

Neomycin sulfate, when absorbed systemically, can potentiate the effects of neuromuscular blocking agents, leading to increased muscle relaxation and respiratory depression. Although this is more relevant for oral or parenteral administration, it is a consideration for patients with extensive skin application or compromised skin barriers.

Patients with known hypersensitivity to erythromycin, neomycin, or any other component of the ointment should avoid its use. Additionally, prolonged use of topical antibiotics can lead to overgrowth of non-susceptible organisms, including fungi, which may require discontinuation of the ointment and initiation of appropriate therapy.

For prescribers, it is crucial to evaluate the patient's full medication profile, including over-the-counter products and supplements, to identify any potential interactions. Monitoring for signs of increased systemic absorption, such as gastrointestinal disturbances or allergic reactions, is recommended, especially in patients with extensive or prolonged use of the ointment.

If you have any questions or need further information regarding the use of this formulation, please reach out to us at Bayview Pharmacy. We are here to assist both patients and healthcare providers in ensuring safe and effective use of this medication.

The Erythromycin 10 mg/g and Neomycin Sulfate 3.5 mg/g topical ointment is a semi-solid formulation specifically designed for external application to the skin. This ointment is dispensed in a tube, making it convenient for precise application to affected areas. The formulation utilizes a greasy or oily base, which not only facilitates the delivery of the active ingredients but also provides a protective barrier that helps retain moisture and promote healing in the skin. This type of base is particularly beneficial for conditions requiring prolonged contact with the medication, as it ensures that the active ingredients remain in place and are absorbed effectively over time.

Erythromycin is a macrolide antibiotic that works by inhibiting bacterial protein synthesis. It binds to the 50S ribosomal subunit of susceptible bacteria, thereby preventing the translocation of peptides. This action effectively halts bacterial growth and replication, making erythromycin particularly effective against a variety of Gram-positive bacteria and some Gram-negative bacteria. In the context of skin infections, erythromycin helps reduce the bacterial load, thereby alleviating symptoms such as redness, swelling, and discomfort associated with bacterial skin infections.

Neomycin sulfate, on the other hand, is an aminoglycoside antibiotic that exerts its effects by binding to the 30S ribosomal subunit of bacteria. This binding interferes with the initiation complex of protein synthesis and causes misreading of mRNA, leading to the production of nonfunctional or toxic peptides. Neomycin is effective against a broad spectrum of Gram-negative bacteria and some Gram-positive bacteria. When used in combination with erythromycin, neomycin provides a complementary mechanism of action, broadening the spectrum of antibacterial activity and enhancing the overall efficacy of the ointment in treating mixed bacterial infections.

This topical ointment is particularly useful for treating skin conditions characterized by inflammation, infection, or the need for wound healing. The dual antibiotic action targets and reduces bacterial colonization, which is often a contributing factor in skin inflammation and delayed wound healing. By reducing the bacterial load, the ointment helps to minimize the inflammatory response, thereby promoting a more rapid and effective healing process. Additionally, the ointment's greasy base helps to soothe and protect the skin, providing relief from irritation and preventing further damage to the affected area.

For patients and prescribers considering the use of this formulation, it is important to apply the ointment as directed, typically to clean, dry skin. The frequency and duration of application will depend on the specific condition being treated and the prescriber's recommendations. As with any antibiotic treatment, it is crucial to complete the full course of therapy to prevent the development of antibiotic resistance and ensure optimal treatment outcomes. If you have any questions or require further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy.

The Erythromycin 10 mg/g/Neomycin Sulfate 3.5 mg/g topical ointment is primarily formulated for the treatment of skin infections, inflammation, and wound healing. However, this versatile formulation may have other potential uses that can be beneficial for both patients and prescribers. Beyond its primary indications, this ointment can be considered for use in managing minor skin irritations and abrasions that are at risk of bacterial infection. The combination of erythromycin, a macrolide antibiotic, and neomycin sulfate, an aminoglycoside antibiotic, provides a broad spectrum of antibacterial activity, making it effective in preventing infection in superficial cuts, scrapes, and burns.

Additionally, this ointment may be used as a prophylactic measure in patients with compromised skin barriers, such as those with eczema or psoriasis, where the risk of secondary bacterial infection is heightened. The greasy or oily base of the ointment not only aids in the delivery of the active ingredients but also provides a protective barrier that can help retain moisture and promote a conducive environment for skin healing. This can be particularly beneficial in dry or cracked skin conditions, where maintaining hydration is crucial for recovery.

For patients undergoing dermatological procedures, such as laser treatments or chemical peels, this ointment may be recommended to prevent infection and facilitate healing of the treated areas. Its application can help soothe the skin and reduce the risk of post-procedural complications. Furthermore, in certain cases, it may be used in conjunction with other therapies to manage chronic skin conditions that are prone to bacterial colonization, thereby enhancing the overall treatment regimen.

It is important for prescribers to consider the patient's overall health status, potential allergies, and the specific characteristics of the skin condition when recommending this ointment for off-label uses. Patients should be advised to apply the ointment as directed and to report any adverse reactions or lack of improvement to their healthcare provider. As with any medication, the benefits and risks should be carefully weighed, and usage should be tailored to the individual needs of the patient. If you have any questions or require further information about this formulation, please reach out to us at Bayview Pharmacy.