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Formulas

Enrofloxacin 22.5 mg/ml Oral Liquid

Our Enrofloxacin 22.5 mg/ml Oral Liquid is a specially crafted medication designed for oral use, ensuring a precise and consistent dose of enrofloxacin in each administration. This liquid formulation is particularly beneficial for patients who experience difficulty swallowing pills, including pediatric and geriatric populations. Enrofloxacin is a fluoroquinolone antibiotic that is effective in treating a range of bacterial infections, including skin infections, respiratory tract infections, and urinary tract infections. By providing this medication in a liquid form, we aim to enhance patient compliance and optimize therapeutic outcomes in the management of these disease states.

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Enrofloxacin
Oral Liquid
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Formula Information

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Enrofloxacin 22.5 mg/ml Oral Liquid is a specially compounded medication designed for oral administration to treat a variety of bacterial infections. This formulation is particularly beneficial for patients who have difficulty swallowing pills, such as children and the elderly, or for those who require precise dosage adjustments that are not available in pre-manufactured tablet or capsule forms. The liquid formulation allows for flexible dosing and is easier to ingest, ensuring that patients receive the exact amount of medication needed for their specific condition.

Enrofloxacin is a fluoroquinolone antibiotic that works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes necessary for DNA replication, transcription, repair, and recombination. This action results in the elimination of the bacterial infection. It is commonly used to treat a range of bacterial infections, including those affecting the skin, urinary tract, respiratory system, and gastrointestinal tract, as well as infections that are systemic in nature. It is important to note that enrofloxacin is primarily used in veterinary medicine, and its use in humans is limited due to potential side effects and the availability of other antibiotics that are better suited for human pharmacokinetics and safety profiles.

For prescribers, it is crucial to consider the specific pathogen involved in the infection and to confirm that it is susceptible to enrofloxacin before prescribing this medication. Additionally, the prescriber should adjust the dose based on the severity of the infection, the site of infection, and the patient's weight and renal function. It is also important to be aware of potential drug interactions and contraindications, such as in patients with a known hypersensitivity to fluoroquinolones or those with a history of tendon disorders related to quinolone use.

Patients should be instructed to shake the bottle well before each use to ensure the medication is evenly distributed. They should also be advised to measure the dose carefully with an appropriate measuring device and to complete the full course of the medication, even if they begin to feel better before the medication is finished, to prevent the development of antibiotic-resistant bacteria. Side effects can include gastrointestinal upset, central nervous system effects, and potential musculoskeletal issues, and patients should be advised to contact their healthcare provider if they experience any adverse reactions.

If you have any questions or require further information about Enrofloxacin 22.5 mg/ml Oral Liquid, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing the highest quality of care and is available to assist with any inquiries regarding this formulation.

Drug Interactions

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Enrofloxacin is a fluoroquinolone antibiotic that is effective against a broad spectrum of gram-negative and gram-positive bacteria. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes necessary for DNA replication, transcription, repair, and recombination. This action leads to the eradication of bacterial pathogens, making enrofloxacin suitable for treating various infections in animals. It is important to note that enrofloxacin is not approved for use in humans and should only be used in veterinary settings.

When considering the use of enrofloxacin 22.5 mg/ml oral liquid, it is crucial to be aware of potential drug interactions that may affect the efficacy of the medication or the health of the patient. Enrofloxacin can interact with several other drugs, leading to increased risk of adverse effects or reduced therapeutic effectiveness. For instance, the concurrent use of enrofloxacin with theophylline can lead to elevated theophylline levels, potentially causing toxicity. Careful monitoring of theophylline levels is advised if these medications must be used together.

Additionally, enrofloxacin may interact with antacids, sucralfate, iron supplements, and multivitamins containing zinc or calcium. These substances can bind to enrofloxacin and reduce its absorption, thereby decreasing its effectiveness. To minimize this interaction, enrofloxacin should be administered at least 2 hours before or 4-6 hours after the administration of these compounds. Non-steroidal anti-inflammatory drugs (NSAIDs) can also interact with enrofloxacin, potentially leading to increased risk of CNS stimulation and convulsive seizures. Caution is advised when using these medications concurrently.

Enrofloxacin is metabolized in the liver and excreted primarily by the kidneys. Drugs that alter the function of these organs may affect the pharmacokinetics of enrofloxacin. For example, concurrent use with other nephrotoxic or hepatotoxic drugs should be approached with caution, as this may increase the risk of toxicity. It is also important to consider the potential for enrofloxacin to interact with other antibiotics. For instance, the simultaneous use of bacteriostatic antibiotics like chloramphenicol, macrolides, and tetracyclines can antagonize the bactericidal effect of enrofloxacin.

Warfarin and other anticoagulants may have their effects potentiated by enrofloxacin, increasing the risk of bleeding. Patients receiving anticoagulant therapy should be closely monitored for changes in prothrombin time or other coagulation parameters. Additionally, enrofloxacin may lower the seizure threshold and should be used with caution in patients receiving other medications that may also lower the seizure threshold, such as certain antidepressants and antipsychotics.

It is essential for prescribers to review the patient's complete medication profile for potential interactions before prescribing enrofloxacin. Patients and caregivers should be instructed to report any signs of adverse reactions or unusual symptoms when enrofloxacin is used in conjunction with other medications. If you have any questions or concerns regarding the use of enrofloxacin 22.5 mg/ml oral liquid or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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Enrofloxacin is a broad-spectrum antibiotic belonging to the fluoroquinolone class, which is effective against a wide range of bacterial infections. The mechanism of action of enrofloxacin involves inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. By doing so, it prevents the bacteria from replicating and transcribing DNA, leading to the elimination of the bacterial infection. The 22.5 mg/ml oral liquid formulation of enrofloxacin is designed to provide a precise concentration of the active ingredient for effective treatment while ensuring ease of administration.

This liquid formulation is particularly beneficial for patients who have difficulty swallowing pills, such as children, the elderly, or those with dysphagia. The liquid form allows for flexible dosing, which can be adjusted according to the patient's weight and severity of the infection. It also ensures that the medication is absorbed quickly and efficiently, as the liquid does not require dissolution like solid dosage forms. This can be especially important in acute infections where a rapid onset of action is desired.

Enrofloxacin 22.5 mg/ml oral liquid is used to treat various bacterial infections, including respiratory tract infections, urinary tract infections, skin infections, and gastrointestinal infections caused by enrofloxacin-sensitive bacteria. It is important to note that fluoroquinolones should be used judiciously to minimize the risk of developing antibiotic resistance. Therefore, enrofloxacin should only be used in cases where the infection is proven or strongly suspected to be caused by bacteria.

For prescribers, it is crucial to consider the potential for drug interactions and contraindications associated with fluoroquinolones, including enrofloxacin. Patients with a history of tendon disorders related to fluoroquinolone use should avoid this medication. Additionally, caution is advised in patients with renal impairment, as dosage adjustments may be necessary. As with all antibiotics, it is important for patients to complete the full course of therapy, even if symptoms improve, to ensure the eradication of the infection and reduce the risk of resistance.

If you have any questions about the enrofloxacin 22.5 mg/ml oral liquid formulation or its use in treating specific bacterial infections, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to ensure safe and effective treatment for your patients.

Other Uses

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Enrofloxacin is a fluoroquinolone antibiotic commonly used in veterinary medicine to treat a wide range of bacterial infections. While it is typically prescribed for specific ailments such as skin infections, respiratory infections, urinary tract infections (UTIs), and certain types of gastrointestinal infections caused by susceptible bacteria, there may be additional alternative uses. For instance, this medication might be indicated in the management of wound infections or to treat otitis externa when less specialized medication choices are ineffective or unavailable. Additionally, although not always a first-line choice, enrofloxacin may be used off-label to manage certain systemic infections or in cases where culture and sensitivity results guide its use against specific pathogens that are known to be sensitive to this drug. It is important to note that this product should only be used under the guidance and prescription of a licensed veterinarian, and strictly in species for which it is safe and indicated.

Moreover, the 22.5 mg/ml oral liquid formulation is particularly suitable for animals that are difficult to treat with tablets or injections. This might include pets that are resistant to swallowing pills, those with certain digestive issues that necessitate a liquid form, or animals that experience stress or trauma from injectable drug administration. The liquid form allows for flexible dosing, adjusted to the specific needs and size of the animal, and can often be mixed with food to improve palatability and compliance.

It is critical for pet owners and prescribers to be aware of the potential side effects and contraindications associated with enrofloxacin, including possible impacts on joint and cartilage development in young animals, and interactions with other medications. Before using this medication for an off-label use, a veterinarian should perform appropriate assessments to determine that the benefits outweigh the risks for the patient in question.

For further guidance on the use of Enrofloxacin 22.5 mg/ml Oral Liquid, for both its primary and extended range of applications, please do not hesitate to reach out to us at Bayview Pharmacy for professional advice and information tailored to each individual case. Our compounding pharmacists are committed to ensuring safe and effective treatment protocols for all our veterinary patients.

Frequently Asked Questions

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What is Enrofloxacin 22.5 mg/ml Oral Liquid used for?

Enrofloxacin 22.5 mg/ml Oral Liquid is an antibiotic used for the treatment of bacterial infections in various species. It is effective in treating respiratory, urinary tract, skin, and gastrointestinal infections, as well as other systemic infections susceptible to enrofloxacin.

How should Enrofloxacin Oral Liquid be administered?

This medication should be given orally. The liquid formulation is designed to be convenient for administration and ensures accurate dosing. It can be given directly by mouth or mixed with a small amount of food if advised by a veterinarian.

Can Enrofloxacin Oral Liquid be given to any pet?

Enrofloxacin Oral Liquid can be prescribed by a veterinarian for pets where it is deemed appropriate. However, it should not be used in animals with a known hypersensitivity to quinolones or in those younger than the age of majority specified by your vet due to the risk of causing cartilage lesions in growing joints.

Are there any potential side effects of Enrofloxacin Oral Liquid?

Some animals may experience side effects from enrofloxacin such as gastrointestinal upsets, including vomiting and diarrhea, or central nervous system signs like lethargy and seizures. If you notice any disturbing symptoms, contact your veterinarian immediately.

What should I do if I miss a dose?

If a dose is missed, administer it as soon as you remember. However, if it's nearly time for the next dose, skip the one missed and return to the regular schedule. Do not double up on doses.

Can Enrofloxacin 22.5 mg/ml Oral Liquid be used with other medications?

It's important to discuss with your veterinarian before combining enrofloxacin with any other medications, as it may interact with certain drugs, including theophylline, cyclosporine, warfarin, and some antacids or sucralfate.

How should Enrofloxacin Oral Liquid be stored?

Store the medication at room temperature, away from light and moisture. Keep it out of the reach of children and pets, and do not use it beyond its expiration date.

How do I determine the correct dosage for my pet?

The correct dosage should be calculated and prescribed by your veterinarian, based on your pet's specific needs, weight, and the severity of the infection being treated.

Is it important to finish the entire prescribed course of Enrofloxacin Oral Liquid?

Yes, it is crucial to finish the entire course of the medication even if your pet seems to be feeling better. Stopping the medication early can lead to a relapse or contribute to antibiotic resistance.

What happens if I overdose my pet with Enrofloxacin Oral Liquid?

In the case of an overdose, seek veterinary medical attention immediately. Symptoms of an overdose might include vomiting, dizziness, or seizures. Your pet will need supportive care based on the severity of the symptoms.

Is Enrofloxacin Oral Liquid safe for pregnant or lactating pets?

The safety of enrofloxacin in pregnant or lactating pets has not been fully established. Use this medication only when prescribed by a veterinarian who has assessed the risks and benefits for your pet's condition.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.