The Dimethyl Sulfoxide 5%/Gabapentin 5%/Ketoprofen 10%/Lidocaine 5% Topical Gel is a compounded medication designed for targeted topical application. This semisolid formulation is dispensed through a pump mechanism, which ensures ease of use and precise dosing. The gel base provides a suitable medium for the active ingredients to be applied directly to the skin, allowing for localized treatment and absorption.

Dimethyl Sulfoxide (DMSO) is known for its ability to penetrate the skin and enhance the absorption of other medications. At a 5% concentration, DMSO acts as a carrier for the other active ingredients in the formulation, potentially improving their efficacy. Gabapentin, also at a 5% concentration, is commonly used for its neuropathic pain-relieving properties. It may help alleviate nerve pain associated with conditions such as diabetic neuropathy or postherpetic neuralgia.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), is included at a 10% concentration. It provides anti-inflammatory and analgesic effects, making it useful in the treatment of conditions like osteoarthritis or other musculoskeletal pain. Lidocaine, a local anesthetic, is present at a 5% concentration to offer immediate and temporary relief from pain by numbing the affected area.

The combination of these four active ingredients in a single topical formulation offers a multimodal approach to pain management. The anti-inflammatory action of ketoprofen, the nerve pain relief from gabapentin, the analgesic effect of lidocaine, and the enhanced delivery provided by DMSO work synergistically. This may result in improved patient outcomes in the management of localized pain conditions without the systemic side effects associated with oral medications.

Patients and prescribers considering this formulation should be aware of the potential for skin irritation and other local side effects, as well as the contraindications and interactions associated with each active ingredient. It is important to use this medication as directed by a healthcare professional and to report any adverse effects or concerns promptly. For further information, personalized advice, or questions regarding this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to providing support and guidance to ensure the safe and effective use of compounded medications.

When considering the use of a compounded topical gel containing Dimethyl Sulfoxide (DMSO) 5%, Gabapentin 5%, Ketoprofen 10%, and Lidocaine 5%, it is important to be aware of potential drug interactions that may occur. This semisolid formulation is designed for targeted application on the skin, and while systemic absorption is generally lower with topical administration compared to oral routes, interactions can still occur.

Dimethyl Sulfoxide (DMSO) can enhance the absorption of other drugs applied topically, which could potentially increase the effects and side effects of the other active ingredients in the gel, such as Gabapentin, Ketoprofen, and Lidocaine. DMSO may also interact with certain medications if there is significant systemic absorption. Patients should be advised to inform their healthcare provider of all medications they are taking, including prescription, over-the-counter, and herbal products.

Gabapentin, when absorbed systemically, has been known to interact with antacids containing aluminum or magnesium, as they may decrease the absorption of Gabapentin. While this is more common with oral administration, it is still important to consider if significant systemic absorption of Gabapentin occurs from the topical application. Additionally, Gabapentin may have additive effects with other central nervous system (CNS) depressants, such as opioids or benzodiazepines, potentially leading to increased sedation or drowsiness.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that, when absorbed systemically, can interact with anticoagulants like warfarin, increasing the risk of bleeding. It may also have additive effects with other NSAIDs, including over-the-counter aspirin, ibuprofen, or naproxen, which could increase the risk of gastrointestinal ulcers or bleeding. Patients taking angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or diuretics should be monitored as NSAIDs can reduce the effectiveness of these drugs and potentially lead to kidney problems.

Lidocaine is a local anesthetic and, if absorbed systemically in significant amounts, can interact with antiarrhythmic drugs such as tocainide and mexiletine, as well as other local anesthetics. Caution is advised when using this medication in patients taking class I antiarrhythmic drugs, as the systemic absorption of Lidocaine can contribute to additive cardiac effects.

This compounded formulation is used to treat various disease states such as neuropathic pain, inflammatory conditions, and localized pain syndromes. DMSO has anti-inflammatory properties and enhances the penetration of other drugs. Gabapentin is used for neuropathic pain, Ketoprofen provides anti-inflammatory and analgesic effects, and Lidocaine offers local anesthetic action for pain relief. The combination of these agents in a topical formulation allows for targeted therapy with potentially reduced systemic side effects.

Patients should be instructed to use this medication as directed by their healthcare provider and to report any unusual symptoms or suspected drug interactions. It is also important to apply the gel to clean, intact skin and to avoid contact with eyes, mucous membranes, and other sensitive areas. If you have any questions or concerns about the use of this compounded medication or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.

The Dimethyl Sulfoxide 5%/Gabapentin 5%/Ketoprofen 10%/Lidocaine 5% Topical Gel is a compounded medication designed to deliver a combination of active ingredients directly to the site of pain or inflammation through the skin. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application. The gel-like consistency ensures that the medication stays where it is applied and facilitates the absorption of the active ingredients.

Dimethyl Sulfoxide (DMSO) is a solvent that has the ability to penetrate the skin and other biological membranes. In this formulation, DMSO serves as a carrier for the other active ingredients, enhancing their absorption through the skin. It also has anti-inflammatory and analgesic properties, which contribute to the overall effectiveness of the gel.

Gabapentin is a medication primarily used to treat neuropathic pain. It works by modulating the activity of certain calcium channels in nerve cells, which helps to reduce the abnormal excitability that leads to pain sensations. When formulated in a topical gel, Gabapentin can target specific areas of the body, potentially reducing systemic side effects.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzymes cyclooxygenase-1 and -2 (COX-1 and COX-2), which are involved in the synthesis of prostaglandins. Prostaglandins are compounds that contribute to inflammation, pain, and fever. By reducing their production, Ketoprofen effectively alleviates inflammation and pain at the site of application.

Lidocaine is a local anesthetic that provides rapid and effective relief from pain by blocking the sodium channels in nerve cells, which prevents the initiation and conduction of nerve impulses. When applied topically, Lidocaine can numb the treated area, providing immediate pain relief.

This combination of DMSO, Gabapentin, Ketoprofen, and Lidocaine in a topical gel is particularly useful for treating localized pain conditions such as neuropathic pain, inflammatory disorders, and soft tissue injuries. By delivering the active ingredients directly to the affected area, this formulation can provide targeted relief with potentially fewer systemic side effects compared to oral medications.

Patients and prescribers considering the use of this compounded formulation should be aware of the potential interactions and contraindications associated with each active ingredient. It is important to use this medication under the guidance of a healthcare professional who can monitor its effectiveness and safety. If you have any questions or require further information about this formulation and how it may benefit specific disease states, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the support and expertise you need.

The Dimethyl Sulfoxide 5%/Gabapentin 5%/Ketoprofen 10%/Lidocaine 5% Topical Gel formulation is primarily designed for the relief of pain and inflammation associated with various conditions. While it is commonly used to treat localized musculoskeletal pain, neuropathic pain, and certain types of chronic pain, there are other potential uses for this formulation that may benefit patients under the care of a healthcare provider. The anti-inflammatory properties of ketoprofen, combined with the analgesic effects of gabapentin and lidocaine, make it a versatile option for conditions such as osteoarthritis, rheumatoid arthritis, sports injuries, and tendonitis. Additionally, dimethyl sulfoxide (DMSO) enhances the penetration of the active drugs, potentially improving their efficacy.

On an off-label basis, this gel might be considered for complex regional pain syndrome (CRPS) due to its multiple mechanisms of action, or for the treatment of localized painful neuropathies, such as postherpetic neuralgia. Some practitioners may also explore its use for certain dermatological conditions that have an inflammatory component, as the anti-inflammatory effect can alleviate symptoms, while lidocaine provides symptomatic relief from itching or pain. However, it is imperative that these alternate uses are guided by a healthcare provider who can assess the potential benefits and risks for each individual patient. We also advise close monitoring for any adverse effects when using the medication for non-standard indications.

Due to the nature of the active ingredients, prescribers should consider the specific patient's condition, concomitant medications, and any history of drug sensitivities when contemplating this formulation for other uses. The semisolid gel base ensures that the medication can be applied to the skin in a controlled manner, which might be particularly beneficial in managing localized symptoms or in situations where systemic drug exposure should be minimized. As with any compounded medication, the precise dosing and delivery via a pump mechanism helps to ensure consistency in drug application.

While studying the utility of this formulation across various conditions, researchers and practitioners are encouraged to report their findings to contribute to the broader knowledge base on the potential applications of such compounded medications. Should you have any questions about this topical formulation or its appropriate use, or if you wish to discuss its potential benefits for specific clinical cases, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is well-prepared to provide further information and support to both patients and prescribers.