Dehydroepiandrosterone (DHEA) 10 mg vaginal suppositories are a compounded formulation designed to deliver DHEA directly to the vaginal tissue. DHEA is a naturally occurring hormone produced by the adrenal glands, serving as a precursor to both estrogen and androgen synthesis. When administered vaginally, DHEA is locally converted into estrogen and androgens within the vaginal tissue, which can help restore hormonal balance without significantly affecting systemic hormone levels.

This localized delivery is particularly beneficial for postmenopausal women experiencing symptoms associated with vulvovaginal atrophy, such as vaginal dryness, irritation, and painful intercourse (dyspareunia). By replenishing the local hormone levels, DHEA vaginal suppositories promote the restoration of healthy vaginal mucosa, increase lubrication, and improve the overall quality of the vaginal environment.

The use of DHEA in vaginal suppositories offers an alternative for those who may not tolerate systemic hormone replacement therapy or prefer a localized treatment option. This method minimizes systemic absorption, reducing the potential for hormone-related side effects elsewhere in the body. It provides targeted relief of menopausal symptoms affecting the vaginal area, enhancing comfort and quality of life.

Patients are advised to insert one 10 mg DHEA suppository into the vagina once daily, preferably at bedtime to allow the medication to work overnight. It is important to follow the prescribing healthcare provider's instructions regarding duration of use and to report any unusual symptoms or side effects promptly.

Common side effects may include mild vaginal irritation or discharge. If any severe reactions occur, such as vaginal bleeding or signs of an allergic reaction, patients should discontinue use and seek medical attention immediately. As with any hormone-containing product, it is essential to discuss personal and family medical history with a healthcare provider to determine if this treatment is appropriate.

For prescribers, DHEA vaginal suppositories can be a valuable addition to the management of postmenopausal vulvovaginal symptoms. Compounded formulations allow for customization to meet individual patient needs, ensuring optimal therapeutic outcomes. Collaboration with a compounding pharmacy like Bayview Pharmacy ensures high-quality preparation and patient-specific dosing.

If you have any questions, please reach out to us.

Dehydroepiandrosterone (DHEA) 10 mg vaginal suppositories are used primarily for the treatment of conditions such as vaginal atrophy, dyspareunia, and other symptoms associated with menopause. DHEA is a hormone that serves as a precursor to androgens and estrogens, and its local application in the form of vaginal suppositories can help alleviate symptoms by increasing local estrogen levels without significantly affecting systemic hormone levels.

When considering the use of DHEA vaginal suppositories, it is important to be aware of potential drug interactions. Although DHEA is generally considered to have a low risk of interactions due to its local application, there are still some considerations to keep in mind. Patients who are taking systemic hormone replacement therapy (HRT) should use DHEA vaginal suppositories with caution, as the combined effects could potentially lead to elevated hormone levels, increasing the risk of side effects such as breast tenderness, mood changes, or thromboembolic events.

Additionally, patients using medications that affect hormone levels, such as oral contraceptives, anti-androgens, or aromatase inhibitors, should consult with their healthcare provider before using DHEA vaginal suppositories. These medications could potentially alter the effectiveness of DHEA or vice versa, leading to suboptimal therapeutic outcomes or increased risk of adverse effects.

Patients with a history of hormone-sensitive conditions, such as breast cancer or endometrial cancer, should discuss the use of DHEA vaginal suppositories with their healthcare provider. Although the local application is designed to minimize systemic absorption, the potential for increased local estrogen levels may still pose a risk in these individuals.

It is also important to consider the potential interaction of DHEA with herbal supplements or over-the-counter products that may influence hormone levels. Patients should inform their healthcare provider of all supplements and medications they are taking to ensure safe and effective use of DHEA vaginal suppositories.

For prescribers, it is crucial to evaluate the patient's overall medication regimen and medical history to identify any potential interactions or contraindications. Monitoring hormone levels and assessing symptom relief can help guide therapy and ensure patient safety.

If you have any questions or need further information regarding the use of Dehydroepiandrosterone 10 mg vaginal suppositories, please reach out to us at Bayview Pharmacy. We are here to assist both patients and healthcare providers in optimizing treatment outcomes.

Dehydroepiandrosterone (DHEA) 10 mg vaginal suppositories are a specialized formulation designed to deliver the hormone DHEA directly to the vaginal tissue. This solid dosage form is inserted into the vagina, where it dissolves or melts, allowing the active ingredient to be absorbed locally. The primary mechanism of action involves the conversion of DHEA into active sex steroids, such as estrogen and testosterone, within the vaginal tissue. This localized conversion is crucial for exerting therapeutic effects, particularly in the treatment of conditions like vulvovaginal atrophy, which is often associated with menopause.

When inserted, the suppository gradually releases DHEA, which is then absorbed by the vaginal mucosa. This localized absorption is beneficial as it minimizes systemic exposure and potential side effects associated with oral or systemic hormone replacement therapies. The increase in local estrogen levels helps to restore the thickness and elasticity of the vaginal epithelium, improve lubrication, and reduce symptoms such as vaginal dryness, itching, and painful intercourse. Additionally, the presence of testosterone can contribute to improved sexual function and libido.

For prescribers, it is important to note that the use of DHEA vaginal suppositories provides a targeted approach to hormone therapy, offering an alternative for patients who may not tolerate systemic hormone treatments. The 10 mg dosage is specifically formulated to achieve therapeutic effects while maintaining a favorable safety profile. Patients should be instructed on the proper insertion technique to ensure optimal absorption and efficacy. It is also essential to monitor patients for any adverse reactions or changes in symptoms, adjusting the treatment regimen as necessary.

For patients, understanding the purpose and benefits of DHEA vaginal suppositories can enhance adherence to the treatment plan. Patients should be aware that it may take several weeks to notice improvements in symptoms, and consistent use as prescribed is crucial for achieving the desired outcomes. If there are any concerns or questions regarding the use of this formulation, patients and prescribers are encouraged to reach out to us at Bayview Pharmacy for further information and support.

Dehydroepiandrosterone (DHEA) 10 mg vaginal suppositories are primarily used for the treatment of vulvovaginal atrophy, a condition often associated with menopause that results in symptoms such as vaginal dryness, irritation, and painful intercourse. However, beyond this primary indication, DHEA vaginal suppositories may have other potential uses that are of interest to both patients and prescribers. These suppositories can be considered for off-label use in conditions where hormonal modulation may be beneficial. For instance, DHEA has been studied for its potential role in improving sexual function and libido in postmenopausal women, as it may help in restoring hormonal balance and enhancing sexual health. Additionally, there is emerging interest in the use of DHEA for its potential benefits in supporting bone health, as it may contribute to bone density maintenance, although more research is needed to fully establish this use.

Furthermore, DHEA has been explored for its potential impact on mood and cognitive function. Some studies suggest that DHEA supplementation could have a positive effect on mood and may help alleviate symptoms of depression, particularly in individuals with low DHEA levels. This could be of particular interest for patients experiencing mood disturbances related to hormonal changes. Additionally, there is ongoing research into the role of DHEA in immune function, as it may have immunomodulatory effects that could be beneficial in certain conditions. However, it is important to note that while these potential uses are promising, they are not yet fully validated by extensive clinical trials, and prescribers should consider the current evidence and individual patient circumstances when contemplating off-label use.

Patients and prescribers should engage in thorough discussions regarding the potential benefits and risks of using DHEA vaginal suppositories for these other purposes. It is crucial to consider individual health profiles, existing medical conditions, and concurrent medications to ensure safe and effective use. As with any medication, monitoring for side effects and efficacy is important, and adjustments to therapy should be made based on patient response. If you have any questions or need further information about the use of DHEA vaginal suppositories, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support tailored to your specific needs.