This formulation contains three active ingredients: Collagenase, Misoprostol, and Phenytoin. Each of these ingredients can interact with other medications, potentially altering their effects. It's important to inform your healthcare provider about all the medications you're currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements.

Collagenase, an enzyme that breaks down collagen in damaged tissues, can interact with anticoagulants like warfarin, increasing the risk of bleeding. If you're taking any blood-thinning medications, your healthcare provider may need to adjust your dosage or monitor you more closely while you're using this cream.

Misoprostol, a synthetic prostaglandin, is used in this formulation for its ability to promote healing and prevent ulcers. However, it can interact with antacids and other medications used to treat stomach acid disorders. These interactions can decrease the effectiveness of Misoprostol. Additionally, Misoprostol can increase the effects of certain drugs used to treat high blood pressure, such as beta-blockers, calcium channel blockers, and ACE inhibitors. This could potentially lead to excessively low blood pressure.

Phenytoin, an anticonvulsant, is included in this formulation for its ability to slow down impulses in the brain and aid in the healing of the skin. Phenytoin can interact with a wide range of medications, including other anticonvulsants, antidepressants, antifungal drugs, certain antibiotics, and some heart medications. These interactions can either increase or decrease the effectiveness of Phenytoin or the interacting drugs. In some cases, they can also increase the risk of side effects.

This formulation is designed to treat a variety of skin conditions. Collagenase helps to debride necrotic tissue and promote healing, Misoprostol aids in the prevention of ulcers and promotes healing, and Phenytoin also aids in the healing process and can help to reduce pain. However, due to the potential for drug interactions, it's important to use this medication under the supervision of a healthcare provider.

If you have any questions about this formulation or its potential interactions with other medications, please don't hesitate to reach out to us. We're here to help ensure that you can use this medication safely and effectively.

This unique formulation combines the therapeutic benefits of Collagenase, Misoprostol, and Phenytoin in a topical cream designed for localized treatment. The cream is dispensed in a pump mechanism, which allows for convenient and controlled application on the skin, ensuring that the active ingredients are absorbed effectively.

Collagenase, the first active ingredient, is an enzyme that breaks down collagen in damaged tissues within the skin. It is often used to promote wound healing, as it helps to remove dead skin and tissue, allowing for the growth of new, healthy tissue. In this formulation, Collagenase is present at a concentration of 250 IU/g, which is a potent dose capable of facilitating significant tissue repair.

Misoprostol, the second active ingredient, is a synthetic prostaglandin E1 analogue. It works by increasing the production of gastric mucus and bicarbonate, which helps to protect the stomach lining. In this topical formulation, Misoprostol is present at a concentration of 0.0024%. While Misoprostol is typically used to prevent stomach ulcers, in a topical formulation, it can help to protect the skin and promote healing.

The third active ingredient, Phenytoin, is an anticonvulsant that also has effects on the skin. At a concentration of 5%, Phenytoin can help to promote wound healing. It works by modulating the immune response, reducing inflammation, and promoting the growth of granulation tissue. This can help to speed up the healing process and reduce the risk of infection.

This formulation is particularly useful in treating a variety of disease states that affect the skin. The combined action of Collagenase, Misoprostol, and Phenytoin can help to promote wound healing, reduce inflammation, and protect the skin, making it an effective treatment for conditions such as ulcers, burns, and other types of skin damage.

As compounding pharmacists, we are committed to providing the highest quality formulations to meet the unique needs of each patient. If you have any questions about this formulation, or if you would like to discuss how it could be used in your specific situation, please don't hesitate to reach out to us at Bayview Pharmacy. We are here to help.

Aside from the traditional treatment of certain disease states, such as skin wounds, ulcers, burns, and post-operative wound healing problems, the unique blend of active ingredients in our Collagenase 250 IU/g/Misoprostol 0.0024%/ Phenytoin 5% Topical Cream formulation may be beneficial for additional uses. Collagenase, a type of enzyme, aids in the breakdown and removal of dead skin and tissue, potentially treating conditions like necrotizing fasciitis and aiding overall in wound debridement. Furthermore, collagenase also finds application in facilitating the treatment of Peyronie's disease and Dupuytren's contracture, although more research needs to be done in this aspect.

Misoprostol, present in the formulation, is typically used to prevent stomach ulcers in patients using nonsteroidal anti-inflammatory drugs. However, when used topically, it may help in wound healing by increasing local blood flow and promoting re-epithelization. It could potentially be used to manage pressure ulcers, although this application is off-label and should be pursued cautiously and under medical supervision.

Topical phenytoin, on the other hand, has been shown to accelerate wound healing, making it potentially beneficial for treating aging-related skin ulcers, diabetic sores, pressure sores, and similar conditions. Its antiepileptic properties might have limited application in this topical formulation, but that doesn't rule out potential benefits in neuropathic pain management.

The combination of these ingredients does not offer a broad-spectrum antifungal or antibacterial property, but an additional antimicrobial agent could be compounded into this formulation if indicated and required, extending the utility of this product.

Please note that while this formulation can provide benefit in a variety of skin conditions, as compounding pharmacists, we strongly advise using it under the supervision of healthcare professionals. The utilization of these medications for non-indicated uses should only be made on a case-by-case basis after careful consideration by the prescriber, and the patient should be monitored carefully for any potential side effects. If you have any questions or would like further clarification, feel free to reach out to us at Bayview Pharmacy.