This compounded topical cream combines Clotrimazole 2%, Ibuprofen 2%, Metronidazole 2%, Nifedipine 0.2%, and Dexpanthenol 3% to provide a multifaceted approach to skin treatment. The cream is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin for localized treatment or absorption of active ingredients.

Clotrimazole is an antifungal agent effective against a variety of fungal infections by inhibiting the growth of fungi on the skin. Metronidazole is an antibiotic and antiprotozoal medication that combats anaerobic bacteria and certain parasites, helping to reduce inflammation and infection. Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), helps to alleviate pain and reduce inflammation at the application site.

Nifedipine, a calcium channel blocker, has vasodilating properties that can improve blood flow to the affected area, potentially aiding in healing processes. Dexpanthenol, a derivative of pantothenic acid (vitamin B5), acts as a skin moisturizer and enhances wound healing by promoting cell regeneration.

Together, these ingredients work synergistically to address various skin conditions that may involve inflammation, infection, and compromised skin integrity. The formulation may be particularly useful in treating complex dermatological conditions where antifungal, antibacterial, anti-inflammatory, vasodilatory, and healing-promoting actions are beneficial.

For prescribers, this customized cream offers a comprehensive treatment option that can be tailored to individual patient needs, especially when standard therapies are insufficient. It allows for targeted therapy with multiple active ingredients in a single application, potentially improving patient compliance and outcomes.

Patients using this cream should apply it as directed by their healthcare provider, typically to clean, dry skin. It's important to inform your physician or pharmacist about any allergies or sensitivities to the components of the cream. Monitor the application site for any signs of adverse reactions, such as increased redness, irritation, or allergic response, and report them promptly to your

This topical cream formulation combines Clotrimazole, Ibuprofen, Metronidazole, Nifedipine, and Dexpanthenol, each contributing to its therapeutic effects. Clotrimazole is an antifungal agent, Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID), Metronidazole is an antibiotic and antiprotozoal, Nifedipine is a calcium channel blocker, and Dexpanthenol is a skin protectant and moisturizer. This combination is designed for localized treatment of conditions that may involve inflammation, infection, and compromised skin integrity.

When considering drug interactions, it is important to note that the systemic absorption of these active ingredients is generally lower with topical application compared to oral or intravenous routes. However, interactions can still occur, particularly if the cream is applied over large areas of the body, used frequently, or if the skin barrier is compromised, leading to increased absorption.

Clotrimazole, when used topically, has minimal systemic absorption, thus reducing the likelihood of significant drug interactions. However, caution should be exercised if the patient is using other topical antifungal agents to avoid potential additive effects or skin irritation.

Ibuprofen, as an NSAID, can potentially interact with other medications that affect renal function, blood pressure, or gastrointestinal health. Although systemic absorption is limited, patients using oral NSAIDs or anticoagulants should be monitored for signs of increased bleeding risk or gastrointestinal irritation. Additionally, patients with a history of NSAID sensitivity should use this formulation cautiously.

Metronidazole, when applied topically, is absorbed in small amounts. However, it can still interact with alcohol, leading to a disulfiram-like reaction characterized by flushing, nausea, and vomiting. Patients should be advised to avoid alcohol consumption during treatment. Additionally, caution is advised if the patient is taking oral metronidazole or other nitroimidazole derivatives to prevent cumulative effects.

Nifedipine, primarily used for its vasodilatory effects, has limited systemic absorption when applied topically. However, patients on oral calcium channel blockers should be monitored for potential additive hypotensive effects. It is also important to consider the patient's overall cardiovascular status when using this formulation.

Dexpanthenol is generally well-tolerated with minimal risk of interactions. It acts as a moisturizer and skin protectant, enhancing the skin barrier function and promoting healing. There are no known significant interactions with other medications, making it a safe component of this formulation.

Overall, while the risk of systemic drug interactions is reduced with topical application, it is essential to consider the patient's complete medication profile and medical history. Patients and prescribers should be aware of the potential for localized skin reactions and systemic effects, particularly in cases of extensive application or compromised skin integrity. If you have any questions or concerns regarding the use of this formulation, please reach out to us for further guidance.

This compounded topical cream formulation combines multiple active ingredients, each serving a specific therapeutic purpose, to provide a comprehensive treatment for various skin conditions. The semisolid preparation is dispensed through a pump mechanism, ensuring a convenient and controlled application directly onto the skin, which facilitates localized treatment and absorption of the active ingredients.

Clotrimazole, an antifungal agent, works by inhibiting the growth of fungi by disrupting the synthesis of ergosterol, an essential component of fungal cell membranes. This action makes it effective in treating fungal infections of the skin, such as athlete's foot, jock itch, and ringworm, by weakening the fungal cell structure, leading to cell death and resolution of the infection.

Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), provides anti-inflammatory and analgesic effects. It works by inhibiting the cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins, compounds that mediate inflammation and pain. By reducing inflammation and pain at the site of application, ibuprofen helps alleviate discomfort associated with various inflammatory skin conditions.

Metronidazole is an antibiotic and antiprotozoal agent that is effective against anaerobic bacteria and certain parasites. In topical formulations, it is commonly used to treat skin conditions like rosacea and bacterial infections by disrupting the DNA synthesis of the microorganisms, leading to their death. Its anti-inflammatory properties also contribute to reducing redness and swelling in affected areas.

Nifedipine, a calcium channel blocker, is included in this formulation for its vasodilatory effects. When applied topically, nifedipine can help improve blood flow to the skin, which may be beneficial in conditions where enhanced circulation aids in healing and symptom relief. This can be particularly useful in treating conditions like Raynaud's phenomenon or other circulatory issues affecting the skin.

Dexpanthenol, a derivative of pantothenic acid (vitamin B5), acts as a moisturizer and skin protectant. It enhances the hydration of the stratum corneum, improves skin barrier function, and promotes wound healing. Dexpanthenol is known for its soothing properties, making it effective in alleviating dryness, irritation, and promoting the repair of damaged skin.

The combination of these active ingredients in a single topical cream allows for a multifaceted approach to treating various skin conditions, addressing fungal infections, inflammation, bacterial infections, circulatory issues, and skin hydration simultaneously. This formulation is particularly beneficial for patients requiring a comprehensive treatment regimen with the convenience of a single application. If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy.

The Clotrimazole 2%/Ibuprofen 2%/Metronidazole 2%/Nifedipine 0.2%/Dexpanthenol 3% Topical Cream is a versatile formulation that can be utilized for a variety of off-label uses beyond its primary indications. This compounded cream combines antifungal, anti-inflammatory, antibacterial, vasodilatory, and skin-protective properties, making it a potential option for conditions that benefit from these combined effects. For instance, the antifungal properties of clotrimazole can be beneficial in managing fungal skin infections that may not be the primary target of treatment, such as tinea versicolor or seborrheic dermatitis, where fungal overgrowth is a contributing factor.

Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), provides localized pain relief and reduces inflammation, which can be advantageous in treating localized musculoskeletal pain or inflammatory skin conditions like localized psoriasis or eczema, where inflammation is a significant component. Metronidazole, known for its antibacterial and anti-inflammatory properties, can be useful in managing conditions like rosacea or perioral dermatitis, where bacterial involvement and inflammation are present. Nifedipine, a calcium channel blocker, can aid in improving blood flow and may be considered for use in conditions like Raynaud's phenomenon or other circulatory issues affecting the skin, where enhanced blood flow can alleviate symptoms.

Dexpanthenol, a derivative of pantothenic acid, is included for its moisturizing and skin barrier-enhancing properties, which can be beneficial in a wide range of dermatological conditions where skin barrier repair is needed, such as in xerosis or after minor skin injuries. The combination of these active ingredients in a semisolid preparation dispensed via a pump mechanism allows for precise and controlled application, ensuring that the medication is delivered effectively to the affected area with minimal waste. This formulation can be particularly useful for patients who require a multifaceted approach to their skin condition, addressing multiple symptoms simultaneously.

It is important for prescribers to consider the individual components and their potential interactions with other medications the patient may be using. Patients should be advised to apply the cream as directed and report any adverse reactions or lack of improvement to their healthcare provider. As with any compounded medication, the use of this formulation should be guided by clinical judgment and tailored to the specific needs of the patient. If you have any questions or need further information about this formulation, please reach out to us at Bayview Pharmacy.