Chlorpromazine Hydrochloride 25 mg/10 mL Rectal Enema is a specially compounded formulation designed for rectal administration, contained in pre-filled enema bottles. This ready-to-use liquid preparation offers a convenient and hygienic method for delivering chlorpromazine directly into the rectum, providing a targeted approach for patients who require alternative routes of medication delivery.

Chlorpromazine is a first-generation antipsychotic medication belonging to the phenothiazine class. It works by blocking dopamine receptors in the brain, which helps alleviate symptoms associated with psychiatric disorders such as schizophrenia, bipolar disorder, and severe behavioral problems. Additionally, chlorpromazine has antiemetic properties, making it effective in controlling nausea and vomiting.

The rectal enema formulation allows for rapid absorption of chlorpromazine through the rectal mucosa, bypassing the gastrointestinal tract and reducing first-pass metabolism by the liver. This can be particularly beneficial for patients who are unable to take medications orally due to factors like severe nausea, vomiting, difficulty swallowing, or other gastrointestinal issues. It provides an alternative when intravenous or intramuscular routes are impractical or contraindicated.

For prescribers, this formulation offers a customizable option to meet the specific needs of patients requiring individualized therapy. Compounding pharmacists at Bayview Pharmacy ensure precise dosing and sterility, adhering to strict regulatory standards. This attention to detail enhances patient safety and therapeutic efficacy.

Patients using the Chlorpromazine HCl Rectal Enema should receive proper instruction on administration techniques to ensure effective delivery and minimize discomfort. The pre-filled enema bottles are designed for ease of use, eliminating the need for additional preparation and ensuring a measured dose with each application.

As with any medication, it is important for patients to use this formulation under the guidance of a healthcare professional. Potential side effects may include drowsiness, dizziness, constipation, or local irritation. Patients should promptly report any adverse reactions or concerns to their healthcare provider.

If you have any questions or need further information about this compounded formulation, please reach out to us.

Chlorpromazine HCl, a phenothiazine antipsychotic, is primarily used to manage psychotic disorders such as schizophrenia, but it also has applications in treating severe nausea and vomiting, intractable hiccups, and acute intermittent porphyria. When administered rectally, as in the Chlorpromazine HCl 25 mg/10 mL Rectal Enema, it provides an alternative route for patients who may have difficulty with oral administration or require rapid absorption. However, like all medications, chlorpromazine can interact with other drugs, potentially altering its effects or increasing the risk of adverse reactions.

Patients and prescribers should be aware that chlorpromazine can interact with central nervous system (CNS) depressants, such as alcohol, benzodiazepines, opioids, and other antipsychotics, which may enhance the sedative effects and increase the risk of respiratory depression. Caution is advised when co-administering these substances, and dosage adjustments may be necessary. Additionally, chlorpromazine may potentiate the hypotensive effects of antihypertensive agents, necessitating careful monitoring of blood pressure and possible modification of antihypertensive therapy.

Chlorpromazine can also interact with medications that prolong the QT interval, such as certain antiarrhythmics, antibiotics, and other antipsychotics, increasing the risk of serious cardiac arrhythmias. It is crucial to evaluate the patient's medication regimen for potential QT-prolonging agents and assess the risk-benefit ratio of concurrent use. Furthermore, chlorpromazine may affect the metabolism of other drugs by inhibiting cytochrome P450 enzymes, particularly CYP2D6, which can lead to increased plasma concentrations of drugs metabolized by this pathway, such as certain antidepressants and beta-blockers.

Patients taking chlorpromazine should be monitored for signs of neuroleptic malignant syndrome, a rare but life-threatening condition that can occur with antipsychotic use, especially when combined with other dopamine antagonists. Additionally, chlorpromazine may lower the seizure threshold, and caution is advised when prescribing to patients with a history of seizures or those taking other medications that can lower the seizure threshold, such as bupropion or tramadol.

It is important for prescribers to conduct a thorough medication review and consider potential drug interactions when initiating chlorpromazine therapy. Patients should be advised to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and supplements, to ensure safe and effective use of the chlorpromazine rectal enema. If you have any questions or require further information, please reach out to us at Bayview Pharmacy.

Chlorpromazine HCl 25 mg/10 mL Rectal Enema is a specialized pharmaceutical formulation designed for rectal administration, providing a unique and effective method for delivering medication directly to the lower gastrointestinal tract. This formulation is particularly beneficial for patients who require targeted treatment for conditions such as constipation, bowel cleansing, or when oral administration is not feasible. The rectal route allows for the medication to bypass the upper gastrointestinal tract, which can be advantageous in cases where oral administration is compromised due to nausea, vomiting, or difficulty swallowing.

Chlorpromazine is a phenothiazine derivative that primarily functions as an antipsychotic medication. However, in this rectal enema formulation, it is utilized for its ability to exert a calming effect on the gastrointestinal tract. By acting on the central nervous system, chlorpromazine can help alleviate symptoms associated with bowel discomfort and facilitate bowel movements. This is particularly useful in managing constipation, where the medication can help relax the intestinal muscles and promote peristalsis, thereby easing the passage of stool.

The ready-to-use liquid formulation is contained in pre-filled enema bottles, ensuring a convenient and hygienic method of administration. Each bottle is designed to deliver a precise dose of 25 mg of chlorpromazine HCl in a 10 mL solution, allowing for easy and controlled application. This eliminates the need for additional preparation, making it an ideal choice for both patients and healthcare providers seeking a straightforward and efficient treatment option.

For bowel cleansing, the rectal enema can be used to prepare the bowel for diagnostic procedures or surgeries. The direct delivery of chlorpromazine to the rectal area helps in softening the stool and stimulating bowel movements, ensuring effective cleansing of the bowel. This targeted approach minimizes systemic absorption and potential side effects, focusing the therapeutic action where it is most needed.

In addition to its use in constipation and bowel cleansing, the rectal enema formulation can also be employed for medication delivery in patients who are unable to take medications orally. This can be particularly beneficial in acute care settings or for patients with severe nausea or vomiting, where maintaining therapeutic drug levels is crucial.

Overall, the Chlorpromazine HCl 25 mg/10 mL Rectal Enema offers a versatile and effective treatment option for various gastrointestinal conditions. Its design ensures ease of use, precise dosing, and targeted delivery, making it a valuable tool in the management of bowel-related issues. If you have any questions or require further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy.

Chlorpromazine HCl 25 mg/10 mL Rectal Enema, while primarily used for its antipsychotic properties, can have several other applications beyond its traditional use in treating constipation, bowel cleansing, or medication delivery. This formulation can be particularly beneficial in managing severe nausea and vomiting, especially in patients who are unable to take oral medications due to gastrointestinal disturbances or those who have difficulty swallowing. The rectal route provides an alternative method of administration that can be more effective in such cases, ensuring that the medication is absorbed efficiently without the need for oral ingestion.

Additionally, Chlorpromazine is known for its sedative properties, which can be utilized in the management of acute agitation or severe anxiety in patients who may not be able to receive medications orally. This can be particularly useful in emergency settings or in patients with psychiatric conditions where rapid sedation is necessary. The rectal enema formulation allows for quick administration and onset of action, providing a practical solution for healthcare providers in managing acute episodes.

In certain cases, Chlorpromazine may also be used as an adjunctive treatment for intractable hiccups, a condition that can be distressing and difficult to manage with standard therapies. The rectal administration of Chlorpromazine can offer relief when other routes are not feasible or effective. Furthermore, this formulation can be considered in palliative care settings, where managing symptoms such as nausea, agitation, or hiccups can significantly improve the quality of life for patients with terminal illnesses.

For prescribers considering this formulation, it is important to evaluate the patient's overall condition, potential contraindications, and the specific therapeutic goals. Patients and caregivers should be educated on the proper administration technique to ensure safety and efficacy. As with any medication, monitoring for potential side effects, such as sedation or hypotension, is crucial. If you have any questions or need further information about the use of Chlorpromazine HCl 25 mg/10 mL Rectal Enema for these or other conditions, please reach out to us at Bayview Pharmacy.