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Chlorpromazine 50 mg/ml Rectal Gel

Chlorpromazine 50 mg/ml Rectal Gel is a semisolid formulation designed for easy and precise application through a pump mechanism. This gel-like consistency allows for targeted treatment and efficient absorption of the active ingredient, Chlorpromazine. This formulation is primarily used in the management of various disease states including Schizophrenia, Bipolar Disorder, Nausea and Vomiting, Hiccups, and Acute Intermittent Porphyria. The rectal administration route provides an alternative for patients who may have difficulty with oral intake or for whom intravenous administration is not suitable.

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Chlorpromazine Hydrochloride
Topical Gel
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Formula Information

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Chlorpromazine 50 mg/ml Rectal Gel is a specially formulated medication designed for targeted treatment of various disease states. This semisolid formulation is dispensed through a pump mechanism, which allows for easy and precise application. The gel-like consistency ensures that the active ingredient, Chlorpromazine, is absorbed effectively into the body.

Chlorpromazine is a type of medication known as a phenothiazine antipsychotic. It works by adjusting the balance of chemicals in the brain to help improve mood, reduce anxiety, and manage psychosis. This makes it an effective treatment for conditions such as Schizophrenia and Bipolar Disorder. Patients with these conditions may experience symptoms such as hallucinations, delusions, or mood swings, and Chlorpromazine can help to manage these symptoms.

In addition to its antipsychotic properties, Chlorpromazine also has antiemetic effects. This means it can be used to treat conditions that cause Nausea and Vomiting. It works by blocking the actions of chemicals in the body that trigger the vomiting reflex. This makes it a useful treatment for patients undergoing chemotherapy or other treatments that may cause severe nausea and vomiting.

Chlorpromazine can also be used to treat persistent Hiccups that have not responded to other treatments. It is not entirely clear how Chlorpromazine treats hiccups, but it is believed to work by relaxing the diaphragm muscles.

Acute Intermittent Porphyria is a rare metabolic disorder that can cause a variety of symptoms, including abdominal pain, vomiting, and neurological complications. Chlorpromazine can help to manage these symptoms by reducing the production of porphyrins, substances that can build up and cause symptoms in people with this condition.

As with any medication, Chlorpromazine 50 mg/ml Rectal Gel should be used under the supervision of a healthcare provider. It is important to use this medication as directed, and to report any side effects to your healthcare provider promptly. If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Drug Interactions

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Chlorpromazine 50 mg/ml Rectal Gel is a potent antipsychotic medication used to manage a variety of conditions including Schizophrenia, Bipolar Disorder, Nausea and Vomiting, Hiccups, and Acute Intermittent Porphyria. It works by altering the actions of certain chemicals in the brain to help improve mood, reduce anxiety, and control symptoms of the aforementioned conditions.

However, like all medications, Chlorpromazine can interact with other drugs, which may increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your healthcare provider or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

Some products that may interact with this drug include: anticholinergic medications (such as atropine, scopolamine), certain antiarrhythmics (such as quinidine, amiodarone), antihistamines (such as diphenhydramine, meclizine), drugs for Parkinson's disease (such as levodopa, carbidopa), lithium, certain narcotic pain relievers (such as meperidine), certain SSRI antidepressants (such as fluoxetine, paroxetine), and certain muscle relaxants (such as cyclobenzaprine).

Chlorpromazine can also interact with certain laboratory tests (including phenylketonuria tests, certain pregnancy tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

It is important to tell your doctor or pharmacist of all the products you use, including prescription drugs, nonprescription drugs, and herbal products, before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Chlorpromazine should not be used with other medications that can cause extrapyramidal symptoms (EPS) or with other medications that prolong the QT interval as it may increase the risk of serious side effects such as irregular heart rhythm and severe muscle stiffness.

Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Remember, it is always important to share with your healthcare provider and pharmacist all of the medications you are taking, including over-the-counter (OTC) medications, vitamins, and herbal supplements so they can monitor for drug interactions.

If you have any questions or concerns about these interactions, please do not hesitate to reach out to us at Bayview Pharmacy. We are here to ensure your safety and effectiveness of your medications.

How Does it Work

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Chlorpromazine 50 mg/ml Rectal Gel is a unique formulation designed to deliver the active ingredient, Chlorpromazine, directly to the body through rectal administration. This method of delivery is particularly beneficial for patients who may have difficulty swallowing tablets or for those who require immediate relief from symptoms.

Chlorpromazine is a type of medication known as a phenothiazine. It works by blocking the action of dopamine, a neurotransmitter in the brain that nerves use to communicate with one another. By reducing the effects of dopamine, Chlorpromazine helps to regulate mood and behavior, making it an effective treatment for conditions such as Schizophrenia and Bipolar Disorder.

In addition to its mood-stabilizing effects, Chlorpromazine also has antiemetic properties, meaning it can help to control nausea and vomiting. It does this by blocking the signals to the brain that would normally trigger the vomiting reflex. This makes it a useful treatment for patients experiencing nausea and vomiting due to various causes, including certain types of surgery or cancer treatment.

Chlorpromazine can also be used to treat persistent hiccups that have not responded to other treatments. It is believed to work by inhibiting the nerve signals that trigger the hiccup reflex, although the exact mechanism is not fully understood.

Acute Intermittent Porphyria is a rare metabolic disorder that can cause a variety of symptoms, including abdominal pain, vomiting, and neurological complications. Chlorpromazine is sometimes used to manage these symptoms, although it is not a cure for the underlying condition. It is thought to work by reducing the production of porphyrins, substances that can build up in the body and cause the symptoms of porphyria.

The gel formulation of Chlorpromazine is designed to be easy to apply and is dispensed through a pump mechanism for precise dosing. The gel is absorbed through the skin, providing targeted treatment and allowing for the rapid onset of effects. This makes it a versatile and convenient option for a variety of patients and conditions.

If you have any questions about Chlorpromazine 50 mg/ml Rectal Gel, or if you would like more information about how it works or how it can be used to treat specific conditions, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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Chlorpromazine 50 mg/ml Rectal Gel can potentially have a range of other uses beyond the primary indications of Schizophrenia, Bipolar Disorder, Nausea and Vomiting, Hiccups, and Acute Intermittent Porphyria. This formulation can be employed as part of the management system in certain cases of severe anxiety and agitation where oral dosing or injection may not be feasible. Patients suffering from conditions manifesting excessive fear or unrest could find benefit from this particular preparation due to its potential for rapid onset of effect with rectal administration.

The rectal route of administration often results in more predictable absorption than oral routes, thereby providing consistent and controlled symptom relief, even in patients with gastrointestinal issues that might impede the absorption of orally-administered medication. Therefore, this product could also potentially be useful in circumstances that require consistent management of symptoms which cannot be effectively achieved with oral or other routes of administration.

The chlorpromazine rectal gel can also be used as an adjunctive treatment for tetanus. In this rare bacterial infection, chlorpromazine acts as a muscle relaxant to control muscle stiffness and spasms, easing the discomfort associated with this condition. Furthermore, the unique pump mechanism ensures precise dosing, minimizing the risk of over or under-dosing, and making this formulation particularly convenient from a patient's perspective.

Lastly, as an antipsychotic, chlorpromazine may also be useful in treating certain mood or behavioral disorders in patients where this type of medication is indicated, but oral or intravenous routes are not an option due to various reasons such as swallowing difficulties or needle fear. It is important to note that all these potential "other uses" should be evaluated by a healthcare provider on a case-by-case basis. In all circumstances, the benefits and risks should be weighed carefully before prescribing this potent antipsychotic medication for off-label use.

If you have any questions or require further clarification about the potential additional uses of Chlorpromazine 50 mg/ml Rectal Gel, feel free to reach out to our knowledgeable team at Bayview Pharmacy. We remain committed to not only supplying high-quality compounded medications but also providing essential educational resources for our clients to enable the optimal use of these products.

Frequently Asked Questions

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What is Chlorpromazine 50 mg/ml Rectal Gel?

Chlorpromazine 50 mg/ml Rectal Gel is a semisolid formulation of chlorpromazine, a medication frequently used for the treatment of certain mental/mood disorders. This gel is specifically designed for rectal administration and is usually dispensed through a pump mechanism for easy and precise application.

How should the Chlorpromazine 50 mg/ml Rectal Gel be used?

This gel is applied rectally using a pump mechanism. Ensure the area is clean before application, and then apply the gel as directed by your doctor. The pump facilitates easy and precise dosage and application.

What is the advantage of using a gel format for Chlorpromazine?

The gel format allows for targeted treatment. Specifically, the rectal administration can ensure a steady absorption of the active ingredients and may minimize potential side effects associated with oral administration of Chlorpromazine.

Can anyone use Chlorpromazine 50mg/ml Rectal Gel?

No, this medication should only be used by the person it was prescribed to, and only for the condition for which it was prescribed. Misuse can result in serious health consequences. Always consult with a healthcare provider before beginning any new medication.

What should I do if I miss a dose?

If you miss a dose, use it as soon as you remember. However, if it is near the time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double up the dose to catch up.

Can Chlorpromazine Rectal Gel be used with other medications?

It varies on the medication in question. Some medicines may interact negatively with Chlorpromazine. Therefore, it's crucial to inform your healthcare provider of all other medicines you're currently taking.

What are the side effects of Chlorpromazine 50 mg/ml Rectal Gel?

Side effects can include drowsiness, dizziness, dry mouth, nausea, constipation, and changes in weight. If any of these side effects persist or worsen, inform your healthcare provider immediately.

How should I store Chlorpromazine Rectal Gel?

Store the Chlorpromazine gel at room temperature, away from light and moisture. Do not freeze it, and keep it out of reach from children and pets.

Can I stop using Chlorpromazine Rectal Gel abruptly?

No, you should not stop using the medication without the advice of a healthcare provider. Stopping the medicine suddenly may cause withdrawal symptoms. Your healthcare provider can provide a plan for slowly decreasing your dose to avoid withdrawal.

What should I do in case of an overdose?

In case of an overdose, seek immediate medical help or call your local poison control center. Symptoms of overdose may include severe drowsiness, severe nausea/vomiting, severe excitement/confusion, seizures, or loss of consciousness.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.