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Formulas

Betamethasone 1 mg/Clotrimazole 10 mg/Gentamicin 3 mg/ml Otic Liquid

This formulation is a combination of Betamethasone 1 mg, Clotrimazole 10 mg, and Gentamicin 3 mg per ml in an otic liquid form. Betamethasone is a potent corticosteroid that reduces inflammation, itching, and redness. Clotrimazole is an antifungal medication that treats fungal infections, while Gentamicin is an antibiotic that works against a wide variety of bacteria. Together, these active ingredients provide a comprehensive treatment for various ear conditions.

Specifically designed for use in the ear canal, this formulation is administered using a specific ear dropper or applicator as directed. It provides targeted treatment for ear infections, inflammation, and fungal infections. The combination of these three active ingredients ensures a broad spectrum of action against the common causes of ear diseases, making it a versatile and effective solution for ear health management.

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Betamethasone
Clotrimazole
Gentamicin Sulfate
Otic Solution
6535d50eff9811c7081485dc
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Formula Information

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This formulation combines three active ingredients: Betamethasone, Clotrimazole, and Gentamicin, each serving a unique purpose in treating various ear conditions. Betamethasone is a potent corticosteroid that reduces inflammation, swelling, and discomfort. Clotrimazole is an antifungal medication that treats and prevents fungal infections, while Gentamicin is an antibiotic that fights bacterial infections.

Together, these three ingredients create a comprehensive treatment for otitis externa, also known as swimmer's ear, and other ear infections. Otitis externa is an inflammation of the outer ear and ear canal often caused by bacterial or fungal infections. Symptoms include pain, redness, swelling, and sometimes discharge from the ear. This formulation can help alleviate these symptoms and treat the underlying infection.

The liquid formulation is designed for easy application directly into the ear canal. It is typically administered using a specific ear dropper or applicator as directed by a healthcare provider. The liquid form allows the medication to reach deep into the ear canal, providing targeted treatment and relief from symptoms.

It's important to note that this medication should not be used in patients with a known hypersensitivity to any of the ingredients, or in those with a perforated eardrum, unless directed by a healthcare provider. Side effects may include temporary burning or stinging upon application. If these persist or worsen, or if symptoms do not improve within a week, contact your healthcare provider.

As compounding pharmacists, we can customize this formulation to meet individual patient needs, such as adjusting the concentration of the active ingredients or altering the vehicle to accommodate allergies or sensitivities. We encourage both patients and prescribers to reach out to us with any questions or concerns about this formulation.

Drug Interactions

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This otic liquid formulation contains three active ingredients: Betamethasone, Clotrimazole, and Gentamicin. Each of these ingredients has a specific role in treating various ear conditions. Betamethasone is a corticosteroid that reduces inflammation, swelling, and discomfort. Clotrimazole is an antifungal medication that treats and prevents fungal infections. Gentamicin is an antibiotic that fights bacteria.

While this formulation is generally safe and effective, it's important to be aware of potential drug interactions. These can alter how the medication works or increase the risk of side effects.

Patients using other corticosteroids, either systemically or topically, should inform their healthcare provider as the combined use with Betamethasone may increase the risk of systemic side effects such as immune suppression, hyperglycemia, or adrenal suppression.

Clotrimazole may interact with certain medications metabolized by the liver enzyme CYP450 3A4. These include certain antiretroviral drugs, calcium channel blockers, and certain statins. Concurrent use may increase the levels of these drugs in the body, potentially leading to toxicity.

Gentamicin may interact with other medications that have the potential to damage the kidneys or nerves of the ear (ototoxic), such as loop diuretics or certain other antibiotics. This can increase the risk of kidney damage or hearing loss. It's important to monitor kidney function and hearing during treatment with this medication, especially if used with other potentially nephrotoxic or ototoxic drugs.

Patients should also avoid using this medication concurrently with live or attenuated vaccines due to the immunosuppressive effects of Betamethasone.

It's important to inform your healthcare provider of all medications you are currently taking, including prescription drugs, over-the-counter medications, and dietary supplements. This will help your healthcare provider to monitor for drug interactions and manage them appropriately.

Remember, this medication is for otic use only and should not be ingested or applied to the eyes. If you experience any unusual symptoms or side effects, contact your healthcare provider immediately.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

How Does it Work

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The Betamethasone/Clotrimazole/Gentamicin otic liquid formulation works by combining the therapeutic effects of three active ingredients: Betamethasone, Clotrimazole, and Gentamicin. Each of these components plays a crucial role in treating various ear conditions, such as infections and inflammation.

Betamethasone is a potent corticosteroid that works by reducing inflammation, itching, and redness. It does this by suppressing the immune response, which reduces the release of chemicals in the body that cause inflammation. This can help to alleviate symptoms such as swelling, redness, and itching associated with ear conditions.

Clotrimazole is an antifungal medication that works by inhibiting the growth of various types of fungi. It does this by interfering with the production of a substance called ergosterol, which is a vital component of fungal cell membranes. Without sufficient ergosterol, the cell membrane becomes unstable and this leads to the death of the fungal cell, thereby treating the infection.

Gentamicin is an antibiotic that works by stopping the growth of bacteria. It does this by binding to the bacteria's ribosomes, which are the parts of the cell that make proteins. By interfering with protein synthesis, gentamicin prevents the bacteria from growing and multiplying, which helps to clear the infection.

When combined in this otic liquid formulation, these three active ingredients provide a comprehensive treatment for various ear conditions. The liquid formulation allows for easy application directly into the ear canal, ensuring that the medication is delivered precisely where it is needed. This targeted approach can help to provide rapid relief from symptoms and speed up the healing process.

It's important to note that this medication should be used as directed by a healthcare professional. Overuse or misuse can lead to decreased effectiveness and potential side effects. If you have any questions about this formulation or how to use it, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is always here to help.

Other Uses

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This liquid formulation that combines betamethasone, clotrimazole, and gentamicin is primarily designed as an otic solution to treat specific ear conditions. It can effectively manage a variety of ear disorders, including ear infections, inflammation, and fungal involvement due to its potent anti-inflammatory, antifungal, and antibiotic properties. However, it is essential to note that this versatile solution can potentially have some other potential uses, even though those are off-label and not the primary intent of the formulation.

Unsafe and without proper medical guidance, but it may have potential utility in addressing skin infections. The antimicrobial properties of gentamicin can help eliminate bacteria causing skin infections, while clotrimazole, an antifungal agent, can take care of any fungal aspects. Betamethasone can help to deal with the associated inflammation. However, this should never be attempted without the explicit recommendation of a healthcare professional.

Similarly, it may also be useful in handling inflammation and infections in other areas, such as the nasal passages. Yet, it is vital to emphasize that its usage in manners other than the prescribed otic application should only be pursued under explicit medical advice, and self-medication could lead to unintended consequences, including worsened symptoms or potential harm.

Additionally, careful consideration should be given to those with specific health conditions or those on certain medications before this solution is prescribed. Betamethasone being a corticosteroid may interact with other drugs and the presence of gentamicin, an aminoglycoside, could potentially cause nephrotoxicity or ototoxicity, particularly in those with kidney disease or other health conditions.

In conclusion, while this formulation provides a specialized and powerful treatment for various ear conditions, it may also have potential for other uses. However, these should always be explored under the careful guidance of a knowledgeable healthcare practitioner. If you have any questions about this product, its uses, or potential interactions, please reach out to us here at Bayview Pharmacy.

Frequently Asked Questions

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What is Betamethasone/Clotrimazole/Gentamicin otic liquid?

This is a compounded liquid formulation specifically designed for use in the ear canal, providing targeted treatment for various ear conditions such as infections or inflammation. It is administered using an ear dropper or applicator as directed.

What conditions is this formulation used to treat?

This medication is used to treat a variety of ear conditions, most commonly ear infections and inflammation.

How is Betamethasone/Clotrimazole/Gentamicin otic liquid administered?

This liquid is administered directly into the ear canal using a specific ear dropper or applicator as directed by a healthcare provider.

Can I use this medication if I'm allergic to one of the ingredients?

No, if you have allergies to betamethasone, clotrimazole, or gentamicin, you should not use this medication. Always inform your healthcare provider of any allergies you may have.

What is the purpose of each component in the medication?

Betamethasone is a corticosteroid that helps to reduce inflammation and itching. Clotrimazole is an antifungal medication that treats fungal infections. Gentamicin is an antibiotic that helps to treat bacterial infections.

How often should I use this medication?

The frequency of usage should be decided by your healthcare provider based on your specific conditions. Always follow your healthcare provider’s instruction.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Can I use this medication in both ears?

Yes, if prescribed by your healthcare provider, it can be used in both ears. However, always follow the specific instructions provided by your healthcare provider.

Are there any side effects of Betamethasone/Clotrimazole/Gentamicin otic liquid?

As with any medication, side effects may occur. Common side effects may include temporary stinging or burning sensation upon application. Severe side effects should be reported to your healthcare provider immediately.

Can I use this otic liquid for conditions not related to ear?

No, this medication is specifically formulated for use in the ear canal and should not be used for any other conditions unless explicitly directed by a healthcare provider.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.