This compounded medication combines Belladonna Extract 10 mg, Caffeine Citrate 100 mg, Ergotamine Tartrate 1 mg, and Acetaminophen 250 mg into a convenient capsule form. The solid dosage forms are composed of two gelatin or vegetarian shells that enclose the medication, allowing for easy swallowing and providing a precise dosage of the active ingredients.

This formulation is designed to provide comprehensive relief for individuals suffering from acute migraine headaches. Ergotamine Tartrate works by constricting blood vessels in the brain, which helps to alleviate the throbbing pain associated with migraines. Caffeine Citrate enhances the effectiveness of Ergotamine by improving its absorption and also contributes its own mild vasoconstrictive properties. Acetaminophen acts as an analgesic and antipyretic, reducing pain and fever that may accompany migraines. Belladonna Extract provides anticholinergic effects, relaxing smooth muscles and reducing gastrointestinal symptoms such as nausea and vomiting that often occur during migraine attacks.

For prescribers, this combination offers a multi-faceted approach to migraine management by addressing various symptoms simultaneously. It can improve patient compliance by reducing the need for multiple medications. When considering this formulation, it's important to evaluate the patient's medical history, particularly for cardiovascular conditions, hypertension, or gastrointestinal disorders. Monitoring for potential side effects such as dizziness, dry mouth, increased heart rate, or gastrointestinal discomfort is advised. Caution is recommended when prescribing to elderly patients or those with pre-existing medical conditions due to the anticholinergic effects

This formulation, consisting of Belladonna Extract, Caffeine Citrate, Ergotamine Tartrate, and Acetaminophen, is designed to provide relief for specific conditions, potentially including migraine headaches and other related ailments. However, it is crucial to be aware of potential drug interactions that may arise from the combination of these active ingredients. Patients and prescribers should exercise caution and consult healthcare professionals when considering this medication, especially if other drugs are being taken concurrently.

Belladonna Extract, known for its anticholinergic properties, can interact with other medications that have similar effects, such as antihistamines, tricyclic antidepressants, and certain antipsychotics. These interactions may enhance anticholinergic side effects, leading to increased risk of dry mouth, blurred vision, constipation, and urinary retention. Additionally, Belladonna may interact with medications that affect the central nervous system, potentially intensifying sedative effects.

Caffeine Citrate, a central nervous system stimulant, can interact with other stimulants, such as amphetamines or certain weight loss medications, potentially leading to increased heart rate, elevated blood pressure, and heightened anxiety. Caffeine may also affect the metabolism of certain drugs, such as theophylline and clozapine, by altering their plasma concentrations, which could necessitate dosage adjustments. Furthermore, caffeine can interfere with the absorption of certain medications, such as bisphosphonates, reducing their efficacy.

Ergotamine Tartrate, used for its vasoconstrictive properties, can interact with other vasoconstrictors, such as triptans or certain decongestants, increasing the risk of severe vasoconstriction and associated complications, such as hypertension or ischemia. Ergotamine should not be used concurrently with potent CYP3A4 inhibitors, such as certain antifungals or macrolide antibiotics, as this can lead to elevated ergotamine levels and increased risk of ergot toxicity, characterized by symptoms such as severe peripheral vasoconstriction and gangrene.

Acetaminophen, a widely used analgesic and antipyretic, can interact with other hepatotoxic drugs, such as certain anticonvulsants or alcohol, increasing the risk of liver damage. Patients should be advised to avoid excessive alcohol consumption and to monitor for signs of liver dysfunction, such as jaundice or elevated liver enzymes, when taking this formulation. Additionally, acetaminophen may interact with warfarin, potentially affecting anticoagulation and necessitating closer monitoring of INR levels.

Given the complexity of potential interactions, it is essential for patients and prescribers to thoroughly review all medications, including over-the-counter drugs and supplements, before initiating therapy with this formulation. If you have any questions or concerns regarding drug interactions or the suitability of this medication for your specific condition, please reach out to us at Bayview Pharmacy for further guidance and support.

This formulation combines Belladonna Extract, Caffeine Citrate, Ergotamine Tartrate, and Acetaminophen into a single capsule, designed to provide a synergistic effect for the treatment of specific disease states, such as migraine headaches. Each component plays a distinct role in alleviating symptoms and addressing the underlying causes of these conditions.

Belladonna Extract, derived from the Atropa belladonna plant, contains alkaloids such as atropine and scopolamine, which exert anticholinergic effects. These compounds work by blocking the action of acetylcholine, a neurotransmitter involved in the transmission of pain signals and the regulation of smooth muscle contractions. By inhibiting these pathways, Belladonna Extract can help reduce muscle spasms and alleviate pain associated with migraines.

Caffeine Citrate acts as a central nervous system stimulant and vasoconstrictor. It enhances the absorption and efficacy of analgesics like acetaminophen, providing faster relief from headache symptoms. Additionally, caffeine's vasoconstrictive properties help counteract the vasodilation that often occurs during a migraine attack, thereby reducing headache intensity.

Ergotamine Tartrate is an ergot alkaloid that specifically targets migraine headaches by constricting dilated blood vessels in the brain. It binds to serotonin receptors, which play a crucial role in the pathophysiology of migraines. By activating these receptors, Ergotamine Tartrate helps restore normal blood flow and alleviates the throbbing pain characteristic of migraines.

Acetaminophen is a widely used analgesic and antipyretic that provides relief from pain and reduces fever. It works by inhibiting the synthesis of prostaglandins in the central nervous system, which are compounds involved in the transmission of pain and inflammation. In this formulation, acetaminophen complements the other active ingredients by providing additional pain relief and enhancing the overall therapeutic effect.

The solid dosage form of this formulation, consisting of two gelatin or vegetarian shells, ensures precise dosing and convenient administration. The encapsulation of these active ingredients allows for easy swallowing and consistent delivery of the medication, making it an effective option for patients seeking relief from migraine headaches and related symptoms.

If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need.

The formulation of Belladonna Extract 10 mg, Caffeine Citrate 100 mg, Ergotamine Tartrate 1 mg, and Acetaminophen 250 mg in capsule form is primarily used for the treatment of migraine headaches. However, this combination may have other potential uses that could be considered by healthcare providers based on their clinical judgment and patient-specific factors. Belladonna extract, known for its anticholinergic properties, may be utilized in managing conditions that benefit from reduced smooth muscle spasms, such as irritable bowel syndrome or certain types of colic, although such uses would be off-label and require careful consideration of the risk-benefit ratio.

Caffeine citrate, a central nervous system stimulant, is sometimes used to enhance the efficacy of analgesics and can be considered in formulations aimed at managing tension-type headaches or other pain conditions where a stimulant effect might be beneficial. Additionally, caffeine's vasoconstrictive properties can be advantageous in treating headaches that involve vascular dilation. Ergotamine tartrate, a well-known ergot alkaloid, is primarily used for its vasoconstrictive effects in migraine treatment, but it may also be considered in certain cases of cluster headaches, although this would be off-label and should be approached with caution due to potential side effects and contraindications.

Acetaminophen, a widely used analgesic and antipyretic, can be employed in a variety of pain management scenarios, including mild to moderate pain relief and fever reduction. Its inclusion in this formulation allows for a broad application in pain management beyond migraines, such as in cases of musculoskeletal pain or dental pain, provided that the other components of the formulation are deemed appropriate for the patient. It is important for prescribers to evaluate the individual components of this formulation and consider any potential interactions or contraindications, especially in patients with complex medical histories or those taking other medications.

As with any compounded medication, the use of this formulation for conditions other than its primary indication should be guided by a thorough understanding of the patient's health status and a careful assessment of the potential benefits and risks. Patients and prescribers are encouraged to discuss any questions or concerns with our team at Bayview Pharmacy to ensure safe and effective use of this medication. Our pharmacists are available to provide detailed information and support tailored to individual patient needs.