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Formulas

Baclofen 2%/Ketamine 10%/Ketoprofen 10% Topical Gel

This formulation is a combination of Baclofen 2%, Ketamine 10%, and Ketoprofen 10% in a topical gel. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The Baclofen component is a muscle relaxant and antispastic agent, used to treat muscle symptoms caused by multiple sclerosis, including spasm, pain, and stiffness. Ketamine, a powerful anesthetic, is used for its analgesic properties and is effective in treating neuropathic pain. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces hormones causing pain and inflammation in the body, thus providing relief from arthritis pain.

Together, these three active ingredients work synergistically to provide relief from various disease states including multiple sclerosis, neuropathic pain, and arthritis.

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Topical Gel
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Formula Information

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This formulation combines Baclofen, Ketamine, and Ketoprofen in a topical gel format. Baclofen is a muscle relaxant and antispasmodic agent, which helps to relieve muscle spasms, tightness, and pain. Ketamine is a potent analgesic that can provide significant pain relief, particularly for neuropathic pain. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain in the body.

The gel is dispensed through a pump mechanism, which allows for easy and precise application on the skin. This targeted treatment facilitates the absorption of the active ingredients directly at the site of pain or inflammation, potentially reducing systemic side effects often associated with oral medications.

This formulation can be used to treat a variety of disease states. It may be particularly beneficial for conditions that involve muscle spasms, inflammation, and pain, such as multiple sclerosis, fibromyalgia, and certain types of arthritis. It may also be used for neuropathic pain conditions, such as postherpetic neuralgia and diabetic peripheral neuropathy.

As with any medication, it's important to use this formulation as directed by your healthcare provider. Side effects may include skin irritation at the application site. If you experience any unusual symptoms, contact your healthcare provider immediately.

It's also important to inform your healthcare provider of any other medications you are currently taking, as there may be potential interactions. This includes over-the-counter medications, vitamins, and herbal supplements.

If you have any questions about this formulation, or if you would like more information, please don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to help.

Drug Interactions

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This formulation combines Baclofen, Ketamine, and Ketoprofen in a topical gel form. Each of these active ingredients has its own potential for drug interactions, which can be amplified when used in combination. It's important to consider these interactions when prescribing or using this medication.

Baclofen is a muscle relaxant and antispasmodic agent. It may interact with other central nervous system depressants like alcohol, benzodiazepines, and opioids, potentially leading to increased sedation or respiratory depression. Concurrent use with antihypertensive drugs may lead to additive hypotensive effects.

Ketamine is a potent NMDA receptor antagonist used for its analgesic properties. It can interact with other CNS depressants, potentially leading to increased sedation, respiratory depression, or even coma. Additionally, concurrent use with monoamine oxidase inhibitors (MAOIs) can lead to hypertensive crisis. It's also important to note that chronic use of ketamine can lead to tolerance and psychological dependence.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It may interact with anticoagulants, increasing the risk of bleeding. Concurrent use with other NSAIDs or corticosteroids can increase the risk of gastrointestinal ulcers or bleeding. Additionally, it may reduce the effectiveness of antihypertensive drugs and diuretics. It's also important to note that ketoprofen can increase the serum concentration of lithium and methotrexate, potentially leading to toxicity.

This formulation is designed for topical application, which can reduce the risk of systemic drug interactions. However, systemic absorption can still occur, especially with prolonged use, large application areas, or damaged skin. Therefore, it's important to consider potential drug interactions even with topical use.

This formulation is used for its analgesic and anti-inflammatory effects, making it useful in conditions like neuropathic pain, musculoskeletal pain, and inflammation. Baclofen can help reduce muscle spasticity, ketamine can provide potent analgesia, and ketoprofen can reduce inflammation and pain. However, it's important to use this medication as directed by a healthcare provider, considering the potential for drug interactions and side effects.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us. We're here to help ensure safe and effective use of this medication.

How Does it Work

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The Baclofen 2%/Ketamine 10%/Ketoprofen 10% Topical Gel is a unique formulation that combines three active ingredients, each with its own mechanism of action, to provide targeted relief from pain and inflammation. This gel is applied topically, directly to the skin, where it is absorbed to provide localized treatment.

Baclofen is a muscle relaxant and antispastic agent. It works by inhibiting the transmission of reflexes at the spinal level, which can help to alleviate muscle spasms, pain, and stiffness. This makes it particularly useful in conditions where muscle spasms contribute to pain and discomfort.

Ketamine, on the other hand, is a NMDA receptor antagonist. It works by blocking the N-Methyl-D-aspartate (NMDA) receptors in the brain and spinal cord, which play a key role in transmitting pain signals. By blocking these receptors, ketamine can help to reduce pain and discomfort.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing the production of prostaglandins, chemicals that cause inflammation, pain, and fever in the body. By reducing these chemicals, ketoprofen can help to alleviate pain and reduce inflammation.

The combination of these three active ingredients in a topical gel formulation allows for targeted treatment. The gel is applied directly to the area of pain or inflammation, allowing the active ingredients to be absorbed through the skin and act directly on the affected area. This can provide more effective relief than oral medications, which must be absorbed through the digestive system and distributed throughout the entire body.

This formulation can be used to treat a variety of disease states, including musculoskeletal conditions such as arthritis and fibromyalgia, neuropathic pain conditions such as postherpetic neuralgia and diabetic neuropathy, and other conditions where pain and inflammation are present.

As compounding pharmacists, we are able to customize this formulation to meet the specific needs of each patient. We can adjust the concentrations of the active ingredients, change the base of the gel, or add other active ingredients as needed. If you have any questions about this formulation, or if you would like to discuss how it could be customized to meet your needs, please reach out to us at Bayview Pharmacy.

Other Uses

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This topical gel formulation of Baclofen 2%/Ketamine 10%/Ketoprofen 10% is primarily used for treating various pain syndromes, including neuropathic pain, fibromyalgia, and neurogenic claudication caused by lumbar spinal stenosis. However, this powerful trifecta of active ingredients has a range of additional utility that extends beyond these primary disease states.

Ketoprofen, a potent nonsteroidal anti-inflammatory drug (NSAID), can provide relief in cases of acute and chronic inflammation, making the formulation potentially effective for conditions like osteoarthritis, rheumatoid arthritis, tendinitis, and bursitis. It also possesses some analgesic and antipyretic properties.

Ketamine, a N-Methyl-D-Aspartate (NMDA) receptor antagonist, can provide pain relief in cases of complex regional pain syndrome (CRPS), phantom limb pain, and postherpetic neuralgia. It is also being increasingly utilized in the treatment of depression and mood disorders, though this use may warrant further research and should be undertaken under close medical supervision.

Baclofen is primarily used as a muscle relaxer and an antispastic agent. Thus, this gel could prove beneficial for conditions like multiple sclerosis or other ailments characterized by muscle spasticity. Furthermore, some studies are exploring the benefit of topical baclofen in the management of gastroesophageal reflux disease (GERD), as it may influence the lower esophageal sphincter.

This wide range of potential uses offers a great deal of flexibility for prescribers seeking a versatile, topically applied treatment option. However, it is essential to remember that this product is highly potent and should only be used under a healthcare provider's guidance. Side effects, drug interactions, and individual patient factors must be taken into account when considering the best therapeutic strategies. If you have any further questions about how this formulation might best serve your needs, we are readily available for consultation at Bayview Pharmacy.

Frequently Asked Questions

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What is Baclofen 2%/Ketamine 10%/Ketoprofen 10% Topical Gel?

It's a compounded medication in a gel form containing Baclofen, Ketamine, and Ketoprofen in specified percentages. This formulation is designed for topical application, allowing active ingredients to be directly absorbed through the skin.

How is this topical gel dispensed?

This gel is dispensed using a pump mechanism, which allows for easy and accurate application of the product onto the skin.

What is the consistency of this medication?

The medication comes in a gel-like consistency. This means it's semisolid, easier to apply, and allows for a smooth application on the skin.

What does targeted treatment mean?

Targeted treatment means the medication is applied directly on a specific area, allowing the active ingredients to be absorbed precisely where needed. This can help in managing symptoms in that particular area more effectively.

How does the medication work?

The ingredients in the gel work by reducing inflammation, pain, and muscle stiffness, providing relief in the targeted areas.

Can this gel be used for other areas of the body?

It's essential to follow the directions provided by your healthcare provider. The gel is generally designed for topical use on specific areas as instructed by your healthcare professional.

Should I rub the gel in?

Apply the gel as directed by your healthcare provider. In general, you should allow the skin to absorb the medication without much rubbing unless instructed otherwise.

What precautions should I take while using this topical gel?

Avoid contact with your eyes, nose, and mouth. It's also essential to wash your hands before and after using the gel unless your healthcare provider instructs you to treat your hands. If the gel gets in your eyes accidentally, wash your eyes with plenty of water.

Can I apply the gel more than the prescribed time for faster relief?

No, always follow your healthcare provider's directions. Overuse of the medication can lead to adverse side effects.

What should I do if I miss a dose?

If you miss a dose, you should apply it as soon as you remember. However, if it's near the time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose to make up for the missed dose.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.