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Amitriptyline HCl 10%/Baclofen 2%/Cyclobenzaprine HCl 2%/Diclofenac Na 8%/Flurbiprofen 8%/Gabapentin 6% Topical Gel

This formulation is a compounded topical gel containing Amitriptyline HCl 10%, Baclofen 2%, Cyclobenzaprine HCl 2%, Diclofenac Na 8%, Flurbiprofen 8%, and Gabapentin 6%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures targeted treatment or absorption of the active ingredients.

The combination of these active ingredients is designed to treat a variety of disease states. Amitriptyline HCl is a tricyclic antidepressant used for its analgesic properties, Baclofen is a muscle relaxant and antispasmodic agent, Cyclobenzaprine HCl is a muscle relaxant, Diclofenac Na and Flurbiprofen are nonsteroidal anti-inflammatory drugs (NSAIDs) used for their analgesic and anti-inflammatory properties, and Gabapentin is an anticonvulsant used for its analgesic properties.

This formulation is typically used in the management of conditions such as neuropathic pain, musculoskeletal pain, inflammation, and muscle spasms. The topical application allows for direct delivery of the medication to the affected area, potentially reducing systemic side effects.

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Amitriptyline Hydrochloride
Cyclobenzaprine Hydrochloride
Diclofenac Sodium
Flurbiprofen
Gabapentin
Baclofen
Topical Gel
653148382e166b5c90fb5330
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Formula Information

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This formulation is a compounded topical gel containing Amitriptyline HCl 10%, Baclofen 2%, Cyclobenzaprine HCl 2%, Diclofenac Na 8%, Flurbiprofen 8%, and Gabapentin 6%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed directly into the targeted area, providing localized relief.

Amitriptyline HCl is a tricyclic antidepressant that is used in this formulation for its analgesic properties, particularly in neuropathic pain. Baclofen is a muscle relaxant and antispasmodic agent, used to relieve muscle spasms, pain, and stiffness. Cyclobenzaprine HCl is another muscle relaxant that works by blocking nerve impulses to the brain. Diclofenac Na and Flurbiprofen are nonsteroidal anti-inflammatory drugs (NSAIDs) that reduce inflammation and pain in the body. Gabapentin is an anticonvulsant and nerve pain medication that is used to treat nerve pain and discomfort.

This combination of ingredients makes the formulation particularly effective for treating conditions such as neuropathic pain, muscle spasms, and inflammation. By applying the gel topically, patients can target specific areas of discomfort, and because the medication is absorbed through the skin, it can provide relief without the systemic side effects often associated with oral medications.

It's important for patients to use this medication as directed by their healthcare provider. The gel should be applied to the affected area(s) as needed, but not more than the prescribed amount. Patients should also avoid contact with eyes, mouth, and other mucous membranes. If any adverse reactions occur, such as skin irritation or allergic reactions, patients should discontinue use and contact their healthcare provider immediately.

For prescribers, it's important to note that this is a compounded medication, meaning it is made specifically for the patient and may not be suitable for all individuals. It's also important to monitor patients for potential interactions with other medications they may be taking, particularly with the Amitriptyline HCl and Gabapentin components of the formulation.

If you have any questions about this formulation, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Drug Interactions

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This topical gel formulation contains a combination of Amitriptyline HCl, Baclofen, Cyclobenzaprine HCl, Diclofenac Na, Flurbiprofen, and Gabapentin. These active ingredients work synergistically to provide relief from various disease states, primarily those involving pain and inflammation. However, as with any medication, there are potential drug interactions that patients and prescribers should be aware of.

Amitriptyline HCl, a tricyclic antidepressant, may interact with other antidepressants, antipsychotics, certain antihypertensives, and anticholinergic drugs. It can increase the risk of serotonin syndrome when combined with other serotonergic drugs. Baclofen, a muscle relaxant, may have additive effects with other central nervous system depressants, including alcohol, benzodiazepines, and opioids.

Cyclobenzaprine HCl, another muscle relaxant, may interact with monoamine oxidase inhibitors (MAOIs), increasing the risk of serious side effects. It can also interact with other CNS depressants, leading to increased sedation. Diclofenac Na, a nonsteroidal anti-inflammatory drug (NSAID), may interact with anticoagulants, antiplatelet drugs, and other NSAIDs, increasing the risk of bleeding. It may also interact with certain antihypertensives and diuretics, potentially reducing their effectiveness.

Flurbiprofen, another NSAID, has similar potential interactions as Diclofenac Na. It may also interact with lithium, increasing the risk of lithium toxicity. Gabapentin, an anticonvulsant, may have additive effects with other CNS depressants. It may also interact with antacids, potentially reducing the absorption of Gabapentin.

It's important to note that this is not an exhaustive list of potential interactions. Patients should inform their healthcare provider of all medications they are currently taking, including prescription drugs, over-the-counter medications, and dietary supplements. Prescribers should carefully consider the potential interactions and adjust the treatment plan accordingly.

This formulation is primarily used to treat conditions involving pain and inflammation, such as arthritis, neuropathic pain, and muscle spasms. The combination of active ingredients provides a multi-modal approach to pain management, targeting different aspects of the pain pathway. The topical application allows for targeted treatment, reducing systemic exposure and potential side effects.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us. We are here to provide the information and support you need to ensure safe and effective treatment.

How Does it Work

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This formulation is a combination of six active ingredients: Amitriptyline HCl, Baclofen, Cyclobenzaprine HCl, Diclofenac Na, Flurbiprofen, and Gabapentin. Each of these ingredients plays a unique role in managing pain and inflammation, and their combined effect can provide significant relief for a variety of disease states.

Amitriptyline HCl is a tricyclic antidepressant that works by increasing the levels of certain chemicals in the brain that help improve mood, pain threshold, and sleep. Baclofen is a muscle relaxer and an antispastic agent. It works by helping to relax the muscles. Cyclobenzaprine HCl is another muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain.

Diclofenac Na and Flurbiprofen are both nonsteroidal anti-inflammatory drugs (NSAIDs). They work by reducing substances in the body that cause pain and inflammation. Gabapentin is an anticonvulsant and nerve pain medication. It works by calming down nerve activity to reduce pain and discomfort.

When applied topically, this formulation allows for targeted treatment. The active ingredients are absorbed through the skin directly into the affected area, providing localized relief without the systemic side effects that can occur with oral medications. The gel-like consistency of the formulation allows for easy application and absorption.

This formulation can be used to treat a variety of disease states that involve pain and inflammation. These include conditions like fibromyalgia, neuropathic pain, musculoskeletal pain, and arthritis. By addressing pain and inflammation from multiple angles, this formulation can provide comprehensive relief.

It's important to note that while this formulation can provide significant relief, it's not a cure for the underlying conditions causing the pain and inflammation. It should be used as part of a comprehensive treatment plan under the guidance of a healthcare provider.

If you have any questions about this formulation, how it works, or how it can be used in your specific situation, don't hesitate to reach out to us. We're here to help.

Other Uses

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In addition to the primary indications, this uniquely compounded medication may be useful in several other clinical scenarios owing to the combined anti-inflammatory, antispasmodic, and analgesic properties of its components. Notably, the variety of pain-relieving and muscle-relaxing constituents in this compound—such as Diclofenac Sodium, Flurbiprofen, Gabapentin, and Baclofen—can potentially aid in the management of fibromyalgia, a complex pain disorder characterized by widespread muscle and soft tissue pain. In some cases, the medication could be utilized as an adjunctive therapy in chronic pain management, specifically neuropathic pain or pain associated with conditions such as osteoarthritis and rheumatoid arthritis. It could also benefit patients with sports injuries and soft tissue trauma by reducing pain and inflammation while promoting muscle relaxation.

Amitriptyline HCl, one of the components of this compound, is traditionally categorized as a tricyclic antidepressant but has been found to have analgesic properties, and can be particularly useful for pain linked with nerve damage. Thus, this zone-specific gel could potentially be employed in managing neuropathic pain associated with conditions like diabetes or herpes zoster infection (shingles). Given the antispasmodic effects of Cyclobenzaprine HCl, the medication may also be employed off-label in conditions with muscle spasms or musculoskeletal pain.

However, it's important to note that all potential indications must be utilized under the specific instruction and continuous supervision of a licensed prescriber. Each patient's unique medical history and present medical condition should always guide the use of this or any other compounded medication. Side effects may include, but are not limited to, skin irritation or sensitivity, drowsiness, or gastrointestinal discomfort. Patients should report any side effects to their medical provider immediately. Before using medicated gels, hands should be washed, and a small, test amount should be applied initially to confirm tolerance. The area should always be cleaned and dried before application.

Please reach out to us at Bayview Pharmacy for any questions or further discussion regarding this formulation. Our team of compounding pharmacists is dedicated to assisting patients and healthcare providers with personalized medication solutions.

Frequently Asked Questions

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What is the Amitriptyline HCl/Baclofen/Cyclobenzaprine HCl/Diclofenac Na/Flurbiprofen/Gabapentin topical gel?

This is a compounded formulation of various active ingredients - Amitriptyline HCl, Baclofen, Cyclobenzaprine HCl, Diclofenac Na, Flurbiprofen, and Gabapentin in a semisolid gel-like consistency. It is dispensed through a pump mechanism to be applied on the skin for targeted treatment or absorption.

How should I use this gel?

Apply an appropriate quantity to the area of pain or nerve irritation as suggested by your healthcare provider. Always wash your hands after application unless hands are the treated area.

What are the compound ingredients for?

These ingredients are used to target and manage various types of chronic pain, nerve irritation, inflammation and muscle spasms.

Is it safe to use this gel regularly?

Yes, this gel is safe for regular use, but should always be used under the supervision of a healthcare provider. Always follow your doctor's instructions for dosage and frequency of use.

What if I miss a dose?

If you miss a dose, apply it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use extra to make up for a missed dose.

Are there any side effects associated with this gel?

Some patients may experience side effects such as redness, rash, or itchiness at the application site. More serious side effects are rare. Always contact your healthcare provider if you are concerned about any potential side effects.

What if the gel gets into my eyes or mouth?

If the gel accidentally gets into your eyes or mouth, immediately rinse thoroughly with water. Contact a healthcare professional if any symptoms persist or elevate.

Can this product be used by pregnant or nursing women?

The safety of this compounded formulation during pregnancy or while nursing has not been firmly established. Always consult with your healthcare provider for advice.

Can I apply other topical products when using this gel?

Consult with your doctor or pharmacist before applying other topical products with this gel to avoid any potential interactions or adverse reactions.

How should I store this gel?

Keep the product at room temperature away from direct sunlight and out of reach of children. Ensure that the cap of the pump mechanism is securely fastened to avoid leakage or drying out of the gel.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.