This formulation is a compounded transdermal gel containing a combination of Amitriptyline 2%, Baclofen 2%, Clonidine 0.23%, Ibuprofen 5%, Ketamine 5.75%, Ketoprofen 5%, and Lidocaine 10%. It is a semisolid formulation that is dispensed through a pump mechanism, allowing for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed directly into the targeted area, providing localized relief.

Amitriptyline is a tricyclic antidepressant that is used in this formulation for its analgesic properties, particularly in neuropathic pain. Baclofen is a muscle relaxant and antispasmodic agent, used to relieve muscle spasms, pain, and stiffness. Clonidine is an alpha-2 adrenergic agonist that can help manage neuropathic pain and has sedative properties. Ibuprofen and Ketoprofen are nonsteroidal anti-inflammatory drugs (NSAIDs) that reduce inflammation and pain in the body. Ketamine is a NMDA receptor antagonist that provides analgesic effects, particularly for neuropathic pain. Lidocaine is a local anesthetic that provides immediate relief from pain and discomfort.

This formulation is used to manage various disease states that involve pain and inflammation. It can be particularly beneficial for patients with neuropathic pain, muscle spasms, and localized inflammation. The combination of these active ingredients works synergistically to provide comprehensive pain management, targeting different aspects of pain perception and inflammation.

Patients should apply the gel to the affected area as directed by their healthcare provider. It is important to wash hands before and after application and avoid contact with eyes, mouth, and open wounds. Some potential side effects may include skin irritation at the application site, drowsiness, dry mouth, and constipation. It is important to discuss any concerns or side effects with your healthcare provider.

Prescribers should consider this formulation for patients who require targeted, localized treatment for pain and inflammation. It may be particularly beneficial for patients who cannot tolerate oral medications or for whom systemic side effects are a concern. As with all compounded medications, this formulation should be prescribed as part of a comprehensive treatment plan and should be monitored for efficacy and tolerability.

If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

This compounded formulation contains a combination of Amitriptyline, Baclofen, Clonidine, Ibuprofen, Ketamine, Ketoprofen, and Lidocaine. Each of these active ingredients has its own potential for drug interactions, which can be amplified when used in combination. It's important to note that this formulation is intended for topical use only, which may reduce the risk of systemic interactions.

Amitriptyline, a tricyclic antidepressant, can interact with other antidepressants, antipsychotics, certain antihistamines, and drugs that affect serotonin levels. It can also interact with certain heart medications and can increase the effects of alcohol.

Baclofen, a muscle relaxant and antispastic agent, can interact with other central nervous system depressants including alcohol, antihistamines, and opioids. It can also interact with drugs that lower blood pressure.

Clonidine, an antihypertensive, can interact with other blood pressure medications, heart medications, and certain psychiatric medications. It can also have interactions with alcohol and CNS depressants.

Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), can interact with other NSAIDs, blood thinners, certain blood pressure medications, and certain types of antidepressants. It can also interact with alcohol and increase the risk of stomach bleeding.

Ketamine, an NMDA receptor antagonist, can interact with other CNS depressants, certain heart medications, and certain types of antidepressants. It can also interact with alcohol and increase the risk of respiratory depression.

Ketoprofen, another NSAID, has similar potential interactions as ibuprofen. It can interact with other NSAIDs, blood thinners, certain blood pressure medications, and certain types of antidepressants. It can also interact with alcohol and increase the risk of stomach bleeding.

Lidocaine, a local anesthetic, can interact with other local anesthetics and certain heart medications. It can also interact with certain types of antidepressants and antipsychotics.

This formulation is typically used to manage pain, particularly neuropathic pain, muscle spasms, and inflammation. The combination of these medications works to numb the affected area, relax the muscles, reduce inflammation, and alter the perception of pain. However, it's important to use this medication under the supervision of a healthcare provider due to the potential for drug interactions and side effects.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us. We're here to help ensure that you can use this medication safely and effectively.

This formulation is a combination of seven active ingredients: Amitriptyline, Baclofen, Clonidine, Ibuprofen, Ketamine, Ketoprofen, and Lidocaine. Each of these ingredients plays a unique role in managing pain and inflammation, and their combined effect can provide significant relief for a variety of disease states.

Amitriptyline is a tricyclic antidepressant that works by increasing the levels of certain chemicals in the brain that help improve mood, pain, and sleep. Baclofen is a muscle relaxer and an antispastic agent. It works by helping to relax the muscles. Clonidine is an alpha-2 adrenergic agonist that decreases pain signals sent to the brain. Ibuprofen and Ketoprofen are nonsteroidal anti-inflammatory drugs (NSAIDs) that work by reducing hormones that cause inflammation and pain in the body. Ketamine is a NMDA receptor antagonist that provides pain relief by blocking the signals of pain from the brain. Lidocaine is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes.

When applied topically in a gel form, these ingredients are absorbed through the skin directly into the affected area. This allows for targeted treatment, reducing systemic side effects often associated with oral administration of these medications. The gel form also allows for easy and precise application, and the pump mechanism ensures that the correct dose is dispensed each time.

This formulation can be used to treat a variety of disease states that involve pain and inflammation. These include, but are not limited to, neuropathic pain, fibromyalgia, musculoskeletal pain, and certain types of chronic pain. It can also be used to manage pain associated with conditions like multiple sclerosis and certain types of cancer.

It's important to note that while this formulation can provide significant relief, it's not a cure for the underlying conditions causing the pain. It should be used as part of a comprehensive treatment plan under the supervision of a healthcare provider.

If you have any questions about this formulation, how it works, or how it can be used to manage specific disease states, please don't hesitate to reach out to us. We're here to help.

This combination of medications, available in a transdermal gel, is primarily formulated for targeted pain management, especially for neuropathic pain, muscle spasms, and inflammation. It facilitates the localized delivery of multiple active ingredients, providing comprehensive symptom control. However, other potential uses can be explored, although these may fall outside of approved indications and should always be pursued under the supervision of a healthcare provider.

In addition to pain management, it may be possible to use this transdermal gel for symptoms of certain skin conditions, given its anti-inflammatory ingredients. It could potentially provide relief for conditions like psoriasis or eczema, which often have an inflammatory component, although more extensive research is needed to confirm this. However, it should not be used on compromised skin or open wounds as the added risk of systemic absorption or local irritation could outweigh potential benefits.

The presence of Amitriptyline, a tricyclic antidepressant, could also suggest some utility in managing symptoms of depression and anxiety, particularly in individuals with a co-existing chronic pain condition. Clonidine, an alpha agonist, is similarly used in psychiatric practice for anxiety disorders or withdrawal symptoms. However, the systemic absorption from a topical formulation may not be sufficient for these effects, and this usage should only be considered where oral or other systemic therapy is contraindicated or ineffective.

This formulation might also provide potential relief for symptoms associated with fibromyalgia and chronic fatigue syndrome, owing to the combination of analgesics, anti-inflammatories, and medications with neuropsychiatric effects. However, the efficacy for these conditions would need to be confirmed by more robust clinical trials. In all cases, the risk of potential side effects and drug interactions associated with this complex formulation should be carefully considered.

Finally, the Lidocaine component offers local anesthesia, making it potentially useful for minor procedures requiring localized numbing. Nevertheless, this application would likely be more relevant in a clinic or hospital setting, rather than for general public usage.

As always, this medication should be used under the guidance of a healthcare professional and any off-label uses should be approached with caution. If you have any questions or concerns about using this formulation, we recommend reaching out to your prescribing provider or to us for further information and advice.